Shaina Chor Mei Huang
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View article: Branched actin networks mediate macrophage-dependent host-microbiota homeostasis
Branched actin networks mediate macrophage-dependent host-microbiota homeostasis Open
Branched actin networks formed by the Arp2/3 complex are essential for immune system function. Patients with loss-of-function mutations in the ARPC5 subunit of the Arp2/3 complex develop inflammation and immunodeficiency after birth, leadi…
View article: Branched actin networks mediate macrophage-dependent host microbiota homeostasis
Branched actin networks mediate macrophage-dependent host microbiota homeostasis Open
Assembly of branched actin networks, driven by the Arp2/3 complex are essential for the function and integrity of the immune system. Patients with loss-of-function mutations in the ARPC5 subunit of the Arp2/3 complex develop inflammation a…
View article: CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes
CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes Open
The inhibitors, CK-666 and CK-869, are widely used to probe the function of actin nucleation by the Arp2/3 complex in vitro and in cells. However, in mammals, the Arp2/3 complex consists of 8 iso-complexes, as three of its subunits (Arp3, …
View article: ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality
ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality Open
The Arp2/3 complex drives the formation of branched actin networks that are essential for many cellular processes. In humans, the ARPC5 subunit of the Arp2/3 complex is encoded by two paralogous genes (ARPC5 and ARPC5L) with 67% identity. …
View article: ARPC5 deficiency leads to severe early onset systemic inflammation and early mortality
ARPC5 deficiency leads to severe early onset systemic inflammation and early mortality Open
The seven subunit Arp2/3 complex drives the formation of branched actin networks that are essential for many cellular processes including cell migration. In humans, the ARPC5 subunit of the Arp2/3 complex is encoded by two paralogous genes…
View article: Latent membrane protein 1 and macrophage‐derived <scp>TNFα</scp> synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma
Latent membrane protein 1 and macrophage‐derived <span>TNFα</span> synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma Open
Invadopodia are actin‐rich membrane protrusions that digest the matrix barrier during cancer metastasis. Since the discovery of invadopodia, they have been visualized as localized and dot‐like structures in different types of cancer cells …
View article: Interplay of Viral Infection, Host Cell Factors and Tumor Microenvironment in the Pathogenesis of Nasopharyngeal Carcinoma
Interplay of Viral Infection, Host Cell Factors and Tumor Microenvironment in the Pathogenesis of Nasopharyngeal Carcinoma Open
Undifferentiated nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection. In addition, heavy infiltration of leukocytes is a common characteristic of EBV-associated NPC. It has long been suggested that…