Anuj Kumar
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View article: Supplementary Materials from Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer
Supplementary Materials from Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer Open
Supplementary materials and methods, Supplementary Tables and Supplementary Figures 1S-10S
View article: Supplementary Data 1 from Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer
Supplementary Data 1 from Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer Open
Analysis of differentially expressed genes between untreated and NFZ-treated VCaP cells.
View article: TCEPVDB: Artificial Intelligence-Based Proteome-Wide Screening of Antigens and Linear T-Cell Epitopes in the Poxviruses and the Development of a Repository
TCEPVDB: Artificial Intelligence-Based Proteome-Wide Screening of Antigens and Linear T-Cell Epitopes in the Poxviruses and the Development of a Repository Open
Background: Poxviruses constitute a family of large dsDNA viruses that can infect a plethora of species including humans. Historically, poxviruses have caused a health burden in multiple outbreaks. The large genome of poxviruses favors rev…
View article: Stream RAG: Instant and Accurate Spoken Dialogue Systems with Streaming Tool Usage
Stream RAG: Instant and Accurate Spoken Dialogue Systems with Streaming Tool Usage Open
End-to-end speech-in speech-out dialogue systems are emerging as a powerful alternative to traditional ASR-LLM-TTS pipelines, generating more natural, expressive responses with significantly lower latency. However, these systems remain pro…
View article: The Trans-Kingdom Spectrum of Mpox-like Lesion Pustules of Suspect Patients in the Mpox Clade Ib Outbreak in Eastern Democratic Republic of the Congo
The Trans-Kingdom Spectrum of Mpox-like Lesion Pustules of Suspect Patients in the Mpox Clade Ib Outbreak in Eastern Democratic Republic of the Congo Open
During infectious disease outbreaks, acquiring genetic data across various kingdoms offers essential information to tailor precise treatment methodologies and bolster clinical, epidemiological, and public health awareness. Metagenomics seq…
View article: Partial deletion of the OPG164 (A36R) transmembrane phosphoprotein in monkeypox virus clade Ib/sh2023 disrupts the active region involving Tyr140
Partial deletion of the OPG164 (A36R) transmembrane phosphoprotein in monkeypox virus clade Ib/sh2023 disrupts the active region involving Tyr140 Open
View article: Aptamer Development for SARS-CoV-2 and Omicron Variants Using the Spike Protein Receptor Binding Domain as a Potential Diagnostic Tool and Therapeutic Agent
Aptamer Development for SARS-CoV-2 and Omicron Variants Using the Spike Protein Receptor Binding Domain as a Potential Diagnostic Tool and Therapeutic Agent Open
Despite various methods for detecting and treating SARS-CoV-2, affordable and easily applicable solutions are still needed. Aptamers can potentially fill this gap. Here, we establish a workflow to identify aptamers that bind to the spike p…
View article: Inhibitory effects of bioactive molecules against nonstructural protein (NSs) of Rift Valley Fever Virus (RVFv): A molecular modeling study
Inhibitory effects of bioactive molecules against nonstructural protein (NSs) of Rift Valley Fever Virus (RVFv): A molecular modeling study Open
Rift Valley fever (RVF), a vector-borne zoonotic disease caused by the Rift Valley Fever Virus arbovirus (RVFv), has had a significant impact on livestock and poses a risk to human health. This RNA virus belongs to the Bunyaviridae family …
View article: Synthesis Characterization and Pharmacological Study of Some Novel Benzimidazole Derivatives
Synthesis Characterization and Pharmacological Study of Some Novel Benzimidazole Derivatives Open
View article: The trans-kingdom spectrum of Mpox-like lesion pustules of suspect patients in the Mpox subclade Ib outbreak in Eastern Democratic Republic of the Congo
The trans-kingdom spectrum of Mpox-like lesion pustules of suspect patients in the Mpox subclade Ib outbreak in Eastern Democratic Republic of the Congo Open
During infectious disease outbreaks, acquiring genetic data across various kingdoms offers essential information to tailor precise treatment methodologies and bolster clinical, epidemiological, and public health awareness. Metagenomics seq…
View article: <p>In-Depth Compare-and-Contrast Analysis of NMR Versus X-Ray Crystallography in Biomolecular Structure Determination</p>
In-Depth Compare-and-Contrast Analysis of NMR Versus X-Ray Crystallography in Biomolecular Structure Determination Open
View article: Unleashing the Immune Arsenal: Development of Broad-spectrum Multiepitope Bluetongue Vaccine Targeting Conserved T Cell Epitopes of Structural Proteins
Unleashing the Immune Arsenal: Development of Broad-spectrum Multiepitope Bluetongue Vaccine Targeting Conserved T Cell Epitopes of Structural Proteins Open
Bluetongue (BT) is a severe arboviral disease affecting sheep, cows, and other wild ruminants, caused by the Bluetongue virus (BTV). The virus has evolved into over 32 serotypes, rendering existing vaccines less effective. While the struct…
View article: Integrating Network Pharmacology and In Silico Analysis to Explore the Bioactive Compounds Against Gastric Cancer Treatment
Integrating Network Pharmacology and In Silico Analysis to Explore the Bioactive Compounds Against Gastric Cancer Treatment Open
View article: Mpox virus pangenomics reveals determinants of subclade Ib
Mpox virus pangenomics reveals determinants of subclade Ib Open
Mpox, formerly monkeypox, is a viral zoonotic disease caused by the mpox virus (MPXV). MPXV, which is phylogenetically divided into Clades I and II, was declared a Public Health Emergency of International Concern for the second time in Aug…
View article: Multiple Protein Profiler 1.0 (MPP): A Webserver for Predicting and Visualizing Physiochemical Properties of Proteins at the Proteome Level
Multiple Protein Profiler 1.0 (MPP): A Webserver for Predicting and Visualizing Physiochemical Properties of Proteins at the Proteome Level Open
Determining the physicochemical properties of a protein can reveal important insights in their structure, biological functions, stability, and interactions with other molecules. Although tools for computing properties of proteins already e…
View article: Immuno-informatics study identifies conserved T cell epitopes in non-structural proteins of Bluetongue virus serotypes: formulation of a computationally optimized next-generation broad-spectrum multi-epitope vaccine
Immuno-informatics study identifies conserved T cell epitopes in non-structural proteins of Bluetongue virus serotypes: formulation of a computationally optimized next-generation broad-spectrum multi-epitope vaccine Open
Introduction Bluetongue (BT) poses a significant threat to the livestock industry, affecting various animal species and resulting in substantial economic losses. The existence of numerous BT virus (BTV) serotypes has hindered control effor…
View article: Formulation of next-generation polyvalent vaccine candidates against three important poxviruses by targeting DNA-dependent RNA polymerase using an integrated immunoinformatics and molecular modeling approach
Formulation of next-generation polyvalent vaccine candidates against three important poxviruses by targeting DNA-dependent RNA polymerase using an integrated immunoinformatics and molecular modeling approach Open
Taken together, formulated next-generation polyvalent vaccines were found to have good efficacy against closely related poxviruses (MPXV, VARV, and VPXV) as demonstrated by our extensive immunoinformatics and molecular modeling evaluations…
View article: Identification of Marker Genes in Infectious Diseases from ScRNA-seq Data Using Interpretable Machine Learning
Identification of Marker Genes in Infectious Diseases from ScRNA-seq Data Using Interpretable Machine Learning Open
A common result of infection is an abnormal immune response, which may be detrimental to the host. To control the infection, the immune system might undergo regulation, therefore producing an excess of either pro-inflammatory or anti-infla…
View article: Complete Genome Sequencing, Annotation, and Mutational Profiling of the Novel Clade I Human Mpox Virus, Kamituga Strain
Complete Genome Sequencing, Annotation, and Mutational Profiling of the Novel Clade I Human Mpox Virus, Kamituga Strain Open
Introduction: Human Mpox (formerly monkeypox) infection is an emerging zoonotic disease caused by the Mpox virus (MPXV). We describe the complete genome annotation, phylogeny, and mutational profile of a novel, sustained Clade I Mpox outbr…
View article: ENHANCING AUTONOMOUS NAVIGATION AND COLLISION AVOIDANCE IN DRONE TECHNOLOGY USING DEEP REINFORCEMENT LEARNING
ENHANCING AUTONOMOUS NAVIGATION AND COLLISION AVOIDANCE IN DRONE TECHNOLOGY USING DEEP REINFORCEMENT LEARNING Open
Drone technology is advancing quickly; effective and secure autonomous navigation systems are crucial. This paper presents a novel approach to enhance autonomous navigation and collision avoidance in drone technology using Deep Reinforceme…
View article: Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics
Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics Open
Juvenile autoimmune hepatitis (JAIH) is a rare autoimmune disorder affecting children, characterized by the immune system’s misguided attack on liver cells, primarily targeting the CYP2D6 autoantigen. This repeated attack leads to hepatic …
View article: Unleashing the Immune Arsenal: Development of Broad-spectrum Multiepitope Bluetongue Vaccine Targeting Conserved T Cell Epitopes of Structural Proteins
Unleashing the Immune Arsenal: Development of Broad-spectrum Multiepitope Bluetongue Vaccine Targeting Conserved T Cell Epitopes of Structural Proteins Open
Bluetongue (BT) is a severe arboviral disease affecting sheep, cows, and other wild ruminants, caused by the Bluetongue virus (BTV). The virus has evolved into over 32 serotypes, rendering existing vaccines less effective. While the struct…
View article: Data from Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer
Data from Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer Open
Fusion of the E-26 transformation-specific (ETS)-related gene (ERG) with transmembrane serine protease 2 (TMPRSS2) is a crucial step in the occurrence and progression of approximately 50% of prostate cancers. Despite signific…
View article: Epidemiology, clinical characteristics, and transmission patterns of a novel Mpox (Monkeypox) outbreak in eastern Democratic Republic of the Congo (DRC):<i>an observational, cross-sectional cohort study</i>
Epidemiology, clinical characteristics, and transmission patterns of a novel Mpox (Monkeypox) outbreak in eastern Democratic Republic of the Congo (DRC):<i>an observational, cross-sectional cohort study</i> Open
Summary (abstract) Background In August 2023, an outbreak of mpox was reported in the eastern part, South Kivu Province, of Democratic Republic of the Congo. In this study, we aimed to investigate the origin of this outbreak and to assess …
View article: IoT-Enabled CVM Design & Architecture for E-Waste Management: A Solution towards Environmental Sustainability
IoT-Enabled CVM Design & Architecture for E-Waste Management: A Solution towards Environmental Sustainability Open
There is exponential growth in electronic devices, and people frequently change or replace these devices, leading to a significant increase in electronic waste (E-waste). Consequently, proper electronic waste management techniques are esse…
View article: PoxiPred: An Artificial-Intelligence-Based Method for the Prediction of Potential Antigens and Epitopes to Accelerate Vaccine Development Efforts against Poxviruses
PoxiPred: An Artificial-Intelligence-Based Method for the Prediction of Potential Antigens and Epitopes to Accelerate Vaccine Development Efforts against Poxviruses Open
Poxviridae is a family of large, complex, enveloped, and double-stranded DNA viruses. The members of this family are ubiquitous and well known to cause contagious diseases in humans and other types of animals as well. Taxonomically, the po…
View article: IC2PCT 2024 TOC
IC2PCT 2024 TOC Open
View article: CDBProm: the Comprehensive Directory of Bacterial Promoters
CDBProm: the Comprehensive Directory of Bacterial Promoters Open
The decreasing cost of whole genome sequencing has produced high volumes of genomic information that require annotation. The experimental identification of promoter sequences, pivotal for regulating gene expression, is a laborious and cost…
View article: Comprehending Rhizospheric Microbes: Metagenomic Insights into the Impact of Pre-Emergence Herbicides in Zero-Till Maize Under Rice-Maize Agroecosystems
Comprehending Rhizospheric Microbes: Metagenomic Insights into the Impact of Pre-Emergence Herbicides in Zero-Till Maize Under Rice-Maize Agroecosystems Open
View article: Inhibition potential of natural flavonoids against selected omicron (B.1.19) mutations in the spike receptor binding domain of SARS-CoV-2: a molecular modeling approach
Inhibition potential of natural flavonoids against selected omicron (B.1.19) mutations in the spike receptor binding domain of SARS-CoV-2: a molecular modeling approach Open
The omicron (B.1.19) variant of contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is considered a variant of concern (VOC) due to its increased transmissibility and highly infectious nature. The spike receptor-bindin…