Explanipedia

Targeting pathogen adhesion molecules to improve COPD outcomes Open

Shakti D. Shukla, E. Haydn Walters · 2025

An Ensemble Random Forest Model for Seismic Energy Forecast Open

Shakti D. Shukla, J. Dhanya, Praveen Kumar, Varun Dutt · 2024

Seismic energy forecasting is critical for hazard preparedness, but current models have limits in accurately predicting seismic energy changes. This paper fills that gap by introducing a new ensemble random forest model designed specifical…

Editorial: Pathogen targeting in chronic respiratory diseases: prevention, therapy and management Open

Shakti D. Shukla, Kamal Dua, Ronan O’Toole · 2024

Citation: Shukla SD, Dua K and O'Toole RF (2024) Editorial: Pathogen targeting in chronic respiratory diseases: prevention, therapy and management. Front. Pharmacol. 15:1407616. doi: 10.3389/fphar.2024.1407616

Faecal microbial transfer and complex carbohydrates mediate protection against COPD Open

Kurtis F. Budden, Shakti D. Shukla, Kate L Bowerman, Annalicia Vaughan, Shaan L. Gellatly , et al. · 2024

Objective Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective th…

Fecal microbial transfer and complex carbohydrates mediate protection against COPD Open

Kurtis F. Budden, Shakti D. Shukla, Kate L Bowerman, Shaan L. Gellatly, David Wood , et al. · 2023

Objective Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective th…

Nutraceuticals and COVID‐19: A mechanistic approach toward attenuating the disease complications Open

Keshav Raj Paudel, Vyoma K. Patel, Sukriti Vishwas, Saurabh Gupta, Sumit Sharma , et al. · 2022

Nutraceuticals have emerged as potential compounds to attenuate the COVID-19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a lar…

Understanding the pathogenesis of occupational coal and silica dust-associated lung disease Open

Kanth Swaroop Vanka, Shakti D. Shukla, Henry M. Gomez, Carole James, Palanisami Thavamani , et al. · 2022

Workers in the mining and construction industries are at increased risk of respiratory and other diseases as a result of being exposed to harmful levels of airborne particulate matter (PM) for extended periods of time. While clear links ha…

Correction to: Targeting intercellular adhesion molecule-1 (ICAM-1) to reduce rhinovirus-induced acute exacerbations in chronic respiratory diseases Open

Shakti D. Shukla, Madhur D. Shastri, Kanth Swaroop Vanka, Niraj Kumar Jha, Harish Dureja , et al. · 2022

Targeting intercellular adhesion molecule-1 (ICAM-1) to reduce rhinovirus-induced acute exacerbations in chronic respiratory diseases Open

Shakti D. Shukla, Madhur D. Shastri, Kanth Swaroop Vanka, Niraj Kumar Jha, Harish Dureja , et al. · 2022

Toll-like receptors, innate immune system, and lung diseases: a vital trilateral association Open

Vyoma K. Patel, Keshav Raj Paudel, Shakti D. Shukla, Gang Liu, Brian G. Oliver , et al. · 2022

Concepts of Advanced Therapeutic Delivery Systems for the Management of Remodeling and Inflammation in Airway Diseases Open

Daljeet Singh Dhanjal, Parvarish Sharma, Meenu Mehta, Murtaza M. Tambuwala, Parteek Prasher , et al. · 2022

Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referr…

The Underappreciated Role of Epithelial Mesenchymal Transition in Chronic Obstructive Pulmonary Disease and Its Strong Link to Lung Cancer Open

Malik Quasir Mahmood, Shakti D. Shukla, Chris Ward, E. Haydn Walters · 2021

The World Health Organisation reported COPD to be the third leading cause of death globally in 2019, and in 2020, the most common cause of cancer death was lung cancer; when these linked conditions are added together they come near the top…

Immunotherapy for Alzheimer's Disease: Current Scenario and Future Perspectives Open

Muhammad Usman, Shanu Bhardwaj, Shatabhisha Roychoudhury, Dhruv Kumar, Αθανάσιος Αλεξίου , et al. · 2021

Alzheimer's disease (AD) is a global health concern owing to its complexity, which often poses a great challenge to the development of therapeutic approaches. No single theory has yet accounted for the various risk factors leading to the p…

Recent trends of NFκB decoy oligodeoxynucleotide-based nanotherapeutics in lung diseases Open

Meenu Mehta, Keshav Raj Paudel, Shakti D. Shukla, Venkata Sita Rama Raju Allam, Vinod K. Kannaujiya , et al. · 2021

Interleukin-13: A pivotal target against influenza-induced exacerbation of chronic lung diseases Open

Madhur D. Shastri, Venkata Sita Rama Raju Allam, Shakti D. Shukla, Niraj Kumar Jha, Keshav Raj Paudel , et al. · 2021

Female gender as a risk factor for developing COPD Open

Shakti D. Shukla, Madhur D. Shastri, Niraj Kumar Jha, Gaurav Gupta, Dinesh Kumar Chellappan , et al. · 2021

An Appraisal of the Current Scenario in Vaccine Research for COVID-19 Open

Wai Chin Chong, Dinesh Kumar Chellappan, Shakti D. Shukla, Gregory M. Peterson, Rahul P. Patel , et al. · 2021

The recent coronavirus disease 2019 (COVID-19) outbreak has drawn global attention, affecting millions, disrupting economies and healthcare modalities. With its high infection rate, COVID-19 has caused a colossal health crisis worldwide. W…

Targeting LIN28: A New Hope in Prostate Cancer Theranostics Open

Garima Shrivastava, Alaa A. A. Aljabali, Seyed Hossein Shahcheraghi, Marzieh Lotfi, Madhur D. Shastri , et al. · 2021

The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A…

Fully integrating pathophysiological insights in COPD: an updated working disease model to broaden therapeutic vision Open

E. Haydn Walters, Shakti D. Shukla, Malik Quasir Mahmood, Chris Ward · 2021

Our starting point is that relatively new findings into the pathogenesis and pathophysiology of airway disease in smokers that lead to chronic obstructive pulmonary disease (COPD) need to be reassessed as a whole and integrated into “mains…

An Overview of Vaccine Development for COVID-19 Open

Seyed Hossein Shahcheraghi, Jamshid Ayatollahi, Alaa A. A. Aljabali, Madhur D. Shastri, Shakti D. Shukla , et al. · 2021

The COVID-19 pandemic continues to endanger world health and the economy. The causative SARS-CoV-2 coronavirus has a unique replication system. The end point of the COVID-19 pandemic is either herd immunity or widespread availability of an…

Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System: A Review on Neurological Impairments and Manifestations Open

Niraj Kumar Jha, Shreesh Ojha, Saurabh Kumar Jha, Harish Dureja, Sachin Kumar Singh , et al. · 2021

Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities Open

Li-Yen Lee, Geena Suet Yin Hew, Meenu Mehta, Shakti D. Shukla, Saurabh Satija , et al. · 2021

The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders Open

Wai Chin Chong, Madhur D. Shastri, Gregory M. Peterson, Rahul P. Patel, Prabuddha S. Pathinayake , et al. · 2021

Inflammation is the result of a complex network of cellular and molecular interactions and mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli, particularly pathogens, to maintain homeostasis and promote ti…

COVID-19 in underlying COPD patients Open

Krishna Sunkara, Venkata Sita Rama Raju Allam, Shakti D. Shukla, Dinesh Kumar Chellappan, Gaurav Gupta , et al. · 2020

Alzheimer's disease-like perturbations in HIV-mediated neuronal dysfunctions: understanding mechanisms and developing therapeutic strategies Open

Niraj Kumar Jha, Ankur Sharma, Saurabh Kumar Jha, Shreesh Ojha, Dinesh Kumar Chellappan , et al. · 2020

Excessive exposure to toxic substances or chemicals in the environment and various pathogens, including viruses and bacteria, is associated with the onset of numerous brain abnormalities. Among them, pathogens, specifically viruses, elicit…

Stability of eosinophilic inflammation in COPD bronchial biopsies Open

E. Haydn Walters, Shakti D. Shukla, Chris Ward · 2020

A claim for cellular inflammation in tissues needs the full picture, with total cell count and full differential counts, and not just data on one specific cell type, in addition to details of what normal looks likehttps://bit.ly/2G0…

Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α. Cancers 2020, 12, 113 Open

Alaa A. A. Aljabali, Hamid A. Bakshi, Faruck Lukmanul Hakkim, Yusuf A. Haggag, Khalid Al‐Batayneh , et al. · 2020

The authors wish to make the following corrections to this paper [...]

Smoking and COVID-19: What we know so far Open

Madhur D. Shastri, Shakti D. Shukla, Wai Chin Chong, Rajendra KC, Kamal Dua , et al. · 2020

Microbial determinants of arthritis Open

Shakti D. Shukla, Madhur D. Shastri, Niraj Kumar Jha, Kamal Dua · 2020

Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease Open

Kate L Bowerman, Saima Firdous Rehman, Annalicia Vaughan, Nancy Lachner, Kurtis F. Budden , et al. · 2020

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