Shalini Anandan
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View article: Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury
Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury Open
Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequelae necessitating the …
View article: Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes
Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes Open
Background: The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health action. This analys…
View article: Author response: Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes
Author response: Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Backgrou…
View article: Genomic analysis unveils genome degradation events and gene flux in the emergence and persistence of S. Paratyphi A lineages
Genomic analysis unveils genome degradation events and gene flux in the emergence and persistence of S. Paratyphi A lineages Open
Paratyphoid fever caused by S . Paratyphi A is endemic in parts of South Asia and Southeast Asia. The proportion of enteric fever cases caused by S . Paratyphi A has substantially increased, yet only limited data is available on the popula…
View article: Global diversity and antimicrobial resistance of typhoid fever pathogens: insights from 13,000<i>Salmonella</i>Typhi genomes
Global diversity and antimicrobial resistance of typhoid fever pathogens: insights from 13,000<i>Salmonella</i>Typhi genomes Open
The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which ma…
View article: A secular trend in invasive non-typhoidal Salmonella in South India, 2000–2020: Identification challenges and antibiogram
A secular trend in invasive non-typhoidal Salmonella in South India, 2000–2020: Identification challenges and antibiogram Open
The clinical epidemiology, serovar distribution and antimicrobial susceptibility patterns of invasive Salmonella isolates from India suggest that there is only a small burden of iNTS disease. However the gradual emergence of AMR in iNTS is…
View article: Genomic Characterization of Mobile Genetic Elements Associated With Carbapenem Resistance of Acinetobacter baumannii From India
Genomic Characterization of Mobile Genetic Elements Associated With Carbapenem Resistance of Acinetobacter baumannii From India Open
With the excessive genome plasticity, Acinetobacter baumannii can acquire and disseminate antimicrobial resistance (AMR) genes often associated with mobile genetic elements (MGEs). Analyzing the genetic environment of resistance genes ofte…
View article: Genomic analysis unveils the role of genome degradation events and gene flux in the emergence and persistence of<i>S</i>. Paratyphi A lineages
Genomic analysis unveils the role of genome degradation events and gene flux in the emergence and persistence of<i>S</i>. Paratyphi A lineages Open
Paratyphoid fever caused by S . Paratyphi A is endemic in parts of Asia and Sub-Saharan Africa. The proportion of enteric fever cases caused by S . Paratyphi A has substantially increased, yet only limited data is available on the populati…
View article: Genomic rearrangements of mobile genetic elements associated with carbapenem resistance of <i>Acinetobacter baumannii</i>
Genomic rearrangements of mobile genetic elements associated with carbapenem resistance of <i>Acinetobacter baumannii</i> Open
With the excessive genome plasticity, Acinetobacter baumannii has the capability to acquire and disseminate antimicrobial resistance genes that are often associated with mobile genetic elements (MGE). Analyzing the genetic environment of r…
View article: Detection of Campylobacter spp, EHEC and EIEC by Real-Time Multiplex PCR: An improved method for organisms that needs special culture
Detection of Campylobacter spp, EHEC and EIEC by Real-Time Multiplex PCR: An improved method for organisms that needs special culture Open
View article: Cost of Illness Due to Severe Enteric Fever in India
Cost of Illness Due to Severe Enteric Fever in India Open
Background Lack of robust data on economic burden due to enteric fever in India has made decision making on typhoid vaccination a challenge. Surveillance for Enteric Fever network was established to address gaps in typhoid disease and econ…
View article: Ileal Perforation and Enteric Fever: Implications for Burden of Disease Estimation
Ileal Perforation and Enteric Fever: Implications for Burden of Disease Estimation Open
Background Ileal perforation occurs in about 1% of enteric fevers as a complication, with a case fatality risk (CFR) of 20%–30% in the early 1990s that decreased to 15.4% in 2011 in South East Asia. We report nontraumatic ileal perforation…
View article: Vancomycin Heteroresistance in <i>Staphylococcus Haemolyticus</i> : Elusive Phenotype
Vancomycin Heteroresistance in <i>Staphylococcus Haemolyticus</i> : Elusive Phenotype Open
These findings illustrate the potential of S. haemolyticus to develop heteroresistance, which emphasizes the need for routine surveillance of S. haemolyticus isolated from intensive care units for infection control practices.
View article: Evaluation of Antimicrobial Susceptibility Profile in<i>Salmonella</i>Typhi and<i>Salmonella</i>Paratyphi A: Presenting the Current Scenario in India and Strategy for Future Management
Evaluation of Antimicrobial Susceptibility Profile in<i>Salmonella</i>Typhi and<i>Salmonella</i>Paratyphi A: Presenting the Current Scenario in India and Strategy for Future Management Open
Background Systematic studies to estimate the disease burden of typhoid and paratyphoid in India are limited. Therefore, a multicenter study on the Surveillance of Enteric Fever in India was carried out to estimate the incidence, clinical …
View article: A Seroepidemiological Survey for Pertussis among Adolescents
A Seroepidemiological Survey for Pertussis among Adolescents Open
View article: Lack of Association of Helicobacter pylori in Laryngeal Pathologies
Lack of Association of Helicobacter pylori in Laryngeal Pathologies Open
View article: Colistin resistance in<i>Acinetobacter baumannii</i>is driven by multiple genomic traits: Evaluating the role of IS<i>Aba1</i>-driven<i>eptA</i>overexpression among Indian isolates
Colistin resistance in<i>Acinetobacter baumannii</i>is driven by multiple genomic traits: Evaluating the role of IS<i>Aba1</i>-driven<i>eptA</i>overexpression among Indian isolates Open
Colistin resistance in Acinetobacter baumannii is mediated by multiple mechanisms. Recently, mutations within pmrAB two component system and overexpression of eptA due to upstream insertion of IS Aba1 play a major role.To characterize coli…
View article: Genomic Epidemiology of Typhoid Highlights the Need for Lineage Resolution Diagnosis in Treatment Decisions
Genomic Epidemiology of Typhoid Highlights the Need for Lineage Resolution Diagnosis in Treatment Decisions Open
View article: Genetic Diversity of Clinical <i>Bordetella Pertussis</i> ST2 Strains in comparison with Vaccine Reference Strains of India
Genetic Diversity of Clinical <i>Bordetella Pertussis</i> ST2 Strains in comparison with Vaccine Reference Strains of India Open
Objectives: Pertussis is a highly contagious disease of the respiratory tract caused by Bordetella pertussis, a bacterium that lives in the mouth, nose, and throat. Current study reports the highly accurate complete genomes o…
View article: Hybrid genome assembly of Shigella sonnei reveals the novel finding of chromosomal integration of an IncFII plasmid carrying a mphA gene
Hybrid genome assembly of Shigella sonnei reveals the novel finding of chromosomal integration of an IncFII plasmid carrying a mphA gene Open
Azithromycin is increasingly being used for the treatment of shigellosis despite a lack of interpretative guidelines and with limited clinical evidence. The present study determined azithromycin susceptibility and correlated this with macr…
View article: Molecular epidemiology of C. diphtheriae shows rapid evolution of strains in India: An update from National Diphtheria Surveillance Network
Molecular epidemiology of C. diphtheriae shows rapid evolution of strains in India: An update from National Diphtheria Surveillance Network Open
View article: Hepatitis A outbreak with the concurrence of Salmonella Typhi and Salmonella Poona infection in children of urban Vellore, south India
Hepatitis A outbreak with the concurrence of Salmonella Typhi and Salmonella Poona infection in children of urban Vellore, south India Open
View article: Genomic investigations of S. Typhi isolated from Community and Hospital settings – An update from SEFI network
Genomic investigations of S. Typhi isolated from Community and Hospital settings – An update from SEFI network Open
Background: S. Typhi "H58/4.3.1", a single dominant MDR-lineage has emerged and spread throughout Asia and Africa over the last 30 years. A large global study speculated South Asia might be the site of original emergence of 4.3.1. Through …
View article: A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend
A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend Open
View article: Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant Shigella sonnei and Local Persistence of S. flexneri Clones in India
Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant Shigella sonnei and Local Persistence of S. flexneri Clones in India Open
Shigella is the second leading cause of bacterial diarrhea worldwide. This has been categorized as a priority pathogen among enteric bacteria by the Global Antimicrobial Resistance Surveillance System (GLASS) of the World Health Organizati…
View article: Phylogenetic and evolutionary analysis reveals the recent dominance of ciprofloxacin resistant <i>S. sonnei</i> and local persistence of <i>S. flexneri</i> clones in India
Phylogenetic and evolutionary analysis reveals the recent dominance of ciprofloxacin resistant <i>S. sonnei</i> and local persistence of <i>S. flexneri</i> clones in India Open
Shigella is the second leading cause of bacterial diarrhea worldwide. Recently S. sonnei seems to be replacing S. flexneri in low and middle-income countries undergoing economic development. Despite this, studies focusing on these species …
View article: Insights into the complete genomes of carbapenem-resistant Acinetobacter baumannii harbouring bla OXA-23, bla OXA-420 and bla NDM-1 genes using a hybrid-assembly approach
Insights into the complete genomes of carbapenem-resistant Acinetobacter baumannii harbouring bla OXA-23, bla OXA-420 and bla NDM-1 genes using a hybrid-assembly approach Open
Carbapenem resistance in Acinetobacter baumannii is due to bla OXA-23 , which is endemic in India. Recently, the sporadic presence of bla OXA-58 as well as the occurrence of dual carbapenemases were observed. The mobility as well as the di…
View article: Draft genome sequence of carbapenem-resistant Elizabethkingia anophelis strain BP8467 clinical isolate from India
Draft genome sequence of carbapenem-resistant Elizabethkingia anophelis strain BP8467 clinical isolate from India Open
The presence of a multidrug-resistant isolate harbouring diverse antimicrobial resistance genes along with numerous virulence factors suggests the risk associated with Elizabethkingia spp. infections. This genome analysis provides insights…
View article: First hybrid complete genome of Aeromonas veronii reveals chromosome-mediated novel structural variant mcr-3.30 from a human clinical sample
First hybrid complete genome of Aeromonas veronii reveals chromosome-mediated novel structural variant mcr-3.30 from a human clinical sample Open
Recent findings demonstrate the origin of the plasmid-mediated colistin resistance gene mcr-3 from aeromonads. The present study aimed to screen for plasmid-mediated colistin resistance among 30 clinical multidrug-resistant (MDR) Aeromonas…
View article: Hepatitis A Outbreak with the Concurrence of Salmonella Typhi and Salmonella Poona Infection in Children of Urban Vellore, South India
Hepatitis A Outbreak with the Concurrence of Salmonella Typhi and Salmonella Poona Infection in Children of Urban Vellore, South India Open
We investigated an outbreak of hepatitis A infection among children in an urban settlement of Vellore, South India. A total of 58 cases of jaundice were reported between April and August 2019. Sera from children who presented with jaundice…