Sadhana Sharma
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View article: Twacha, Vata and Mann: An Ayurvedic Approach to Psychodermatology
Twacha, Vata and Mann: An Ayurvedic Approach to Psychodermatology Open
Introduction: In Ayurveda, Twak Vikar (Skin Disease) encompasses all pathological conditions affecting the skin physiology and anatomy, reflecting the body's and mind's state. The skin is influenced by psychological factors impacting quali…
View article: Unraveling the biological potential of skin fibroblast: responses to TNF-α, highlighting intracellular signaling pathways and secretome
Unraveling the biological potential of skin fibroblast: responses to TNF-α, highlighting intracellular signaling pathways and secretome Open
This study advances the biological understanding of skin fibroblast responses to TNF-α, revealing their intracellular pathways and secretome. It discloses techniques for leveraging fibroblasts' potential as in vitro models to identify infl…
View article: PLASTINATION: AN OVERVIEW OF THE REVOLUTIONARY TECHNIQUE IN PRESERVING BIOLOGICAL SPECIMENS FOR EDUCATION AND RESEARCH
PLASTINATION: AN OVERVIEW OF THE REVOLUTIONARY TECHNIQUE IN PRESERVING BIOLOGICAL SPECIMENS FOR EDUCATION AND RESEARCH Open
Plastination is a novel technique for biological specimen preservation. Plastination substitutes curable polymers for water and lipids in tissues, making specimens long-lasting, non-toxic, and odorless in contrast to conventional preservat…
View article: Surgical Removal of a Long-standing Impacted Tooth in Upper Alveolus Following Blast Injury: A Case Report
Surgical Removal of a Long-standing Impacted Tooth in Upper Alveolus Following Blast Injury: A Case Report Open
Injuries sustained from foreign bodies and burns after oil drum explosions are addressed immediately. This case reports a rare long-standing retained tooth after such an explosion. A 65-year-old male with a history of a victim of explosion…
View article: Association of circulatory chemerin levels with the severity of pre-eclampsia: A systematic review and bootstrapped meta-analysis
Association of circulatory chemerin levels with the severity of pre-eclampsia: A systematic review and bootstrapped meta-analysis Open
Introduction This study presents a systematic review and meta-analysis to investigate the association between circulating chemerin levels and the severity of preeclampsia (PE). Material and Methods A thorough search was conducted across mu…
View article: Microbiome- and Host Inflammasome-Targeting Inhibitor Nanoligomers Are Therapeutic in the Murine Colitis Model
Microbiome- and Host Inflammasome-Targeting Inhibitor Nanoligomers Are Therapeutic in the Murine Colitis Model Open
Autoimmune and autoinflammatory diseases account for more than 80 chronic conditions affecting more than 24 million people in the US. Among these autoinflammatory diseases, noninfectious chronic inflammation of the gastrointestinal (GI) tr…
View article: Exploring Marma Points Activation during Vajrasana Practice
Exploring Marma Points Activation during Vajrasana Practice Open
Introduction: Yoga is an ancient Indian discipline that strives to combine an individual's physical, mental, and spiritual components. Vajrasana, also known as Thunderbolt Pose, is a foundational Yoga pose noted for its stability and advan…
View article: Inflammasome-Inhibiting Nanoligomers are Neuroprotective Against Space-Induced Pathology in Healthy and Diseased 3D Human Motor and Pre-Frontal Cortex Brain Organoids
Inflammasome-Inhibiting Nanoligomers are Neuroprotective Against Space-Induced Pathology in Healthy and Diseased 3D Human Motor and Pre-Frontal Cortex Brain Organoids Open
Microgravity and space environment has been linked to deficits in neuromuscular and cognitive capabilities, hypothesized to occur due to accelerated aging and neurodegeneration in space. While the specific mechanisms are still being invest…
View article: Brain-Penetrant NF-κB and NLRP3 Targeting Nanoligomers are Therapeutic in Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s Disease (AD) Human Organoid and Mouse Models
Brain-Penetrant NF-κB and NLRP3 Targeting Nanoligomers are Therapeutic in Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s Disease (AD) Human Organoid and Mouse Models Open
Millions of people suffer worldwide from neurodegenerative diseases ranging from rapidly progressing and fatal motor neuron diseases like Amyotrophic Lateral Sclerosis (ALS) to more chronic illnesses such as frontotemporal dementia (FTD) a…
View article: Microbiome- and Host Inflammasome-Targeting Inhibitor Nanoliogmers are Therapeutic in Murine Colitis Model
Microbiome- and Host Inflammasome-Targeting Inhibitor Nanoliogmers are Therapeutic in Murine Colitis Model Open
Autoimmune and autoinflammatory diseases account for more than 80 chronic conditions affecting more than 24 million people in the US. Amongst these autoinflammatory diseases, non-infectious chronic inflammation of the gastrointestinal (GI)…
View article: Large- and Small-Animal Studies of Safety, Pharmacokinetics (PK), and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs
Large- and Small-Animal Studies of Safety, Pharmacokinetics (PK), and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs Open
Immune malfunction or misrecognition of healthy cells and tissue, termed autoimmune disease, is implicated in more than 80 disease conditions and multiple other secondary pathologies. While pan-immunosuppressive therapies like steroids off…
View article: Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy
Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy Open
Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-asso…
View article: Chemometric method development for the determination of naringin and verapamil
Chemometric method development for the determination of naringin and verapamil Open
Background By resolving complicated spectra from drug combinations, chemometric techniques are valuable for multi-component investigation. The capacity to properly estimate combinations of components without separating drugs from their mix…
View article: Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model
Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model Open
Multiple Sclerosis (MS) is a debilitating autoimmune disease that impacts millions of patients worldwide, disproportionately impacting women (4:1), and often presenting at highly productive stages of life. This disease affects the spinal c…
View article: Post-Coronavirus Disease-2019 Rhino-orbital Mucormycosis: A Case Report
Post-Coronavirus Disease-2019 Rhino-orbital Mucormycosis: A Case Report Open
Background: Rhino-orbital-cerebral mucormycosis (ROCM) is a rare, opportunistic, angio-invasive, and fatal infection caused by mold fungi of the genera Rhizopus, Mucor, and Rhizomucor. The global incidence of ROCM is 0.005-1.7 per million,…
View article: Surgeries and Outcomes in Subluxated and Dislocated Lens in Eastern Nepal
Surgeries and Outcomes in Subluxated and Dislocated Lens in Eastern Nepal Open
Introduction: Many ocular or systemic conditions can cause weakening of the zonules, leading to subluxation or complete dislocation of lens into the anterior chamber or vitreous cavity. Objectives: To evaluate the outcome of surgery in cas…
View article: Changes in Central Corneal Thickness and Central Macular Thickness following Uncomplicated Small-incision Cataract Surgery
Changes in Central Corneal Thickness and Central Macular Thickness following Uncomplicated Small-incision Cataract Surgery Open
Introduction: Cataract surgery is an invasive procedure that causes mechanical and inflammatory insult to the eye. Objectives: The objective was to study the changes in central corneal thickness (CCT) which is an indirect indicator of corn…
View article: Association of Meibomian Gland Dysfunction with Serum Lipid Profile: A Hospital-based Cross-sectional study
Association of Meibomian Gland Dysfunction with Serum Lipid Profile: A Hospital-based Cross-sectional study Open
Introduction: Meibomian gland dysfunction (MGD) frequently leads to ocular surface disease, yet its impact on patients’ overall health is often overlooked. With increase in sedentary lifestyle, decreased physical activities and exposure to…
View article: Newborn screening for congenital hypothyroidism, congenital adrenal hyperplasia and glucose-6-phosphate dehydrogenase deficiency in Bihar: A pressing priority in today's time
Newborn screening for congenital hypothyroidism, congenital adrenal hyperplasia and glucose-6-phosphate dehydrogenase deficiency in Bihar: A pressing priority in today's time Open
Background and Objective: Newborn screening (NBS) aims towards early detection of congenital disorders or prevention of intellectual and physical defects and life-threatening illness. Three disorders namely congenital hypothyroidism (CH), …
View article: Variations in antioxidant status in ischemic stroke: A case control study in Indian population
Variations in antioxidant status in ischemic stroke: A case control study in Indian population Open
Objectives An imbalance between the levels of oxidants and antioxidants, a state of oxidative stress, leads to production of Reactive Oxygen Species. Overproduction of these species plays a crucial role in pathogenesis of ischemic stroke. …
View article: Comparative study of the effects of laser peripheral iridotomy and cataract surgery on anterior chamber angle parameters in primary angle closure suspect patients
Comparative study of the effects of laser peripheral iridotomy and cataract surgery on anterior chamber angle parameters in primary angle closure suspect patients Open
Introduction Prophylactic laser peripheral iridotomy (LPI) and cataract surgery are considered the primary treatments for primary angle closure suspect (PACS) as they have proven effectiveness in widening the iridocorneal angle and address…
View article: A Case of Retinal Artery Macroaneurysm: A Ticking Time Bomb of the Eye
A Case of Retinal Artery Macroaneurysm: A Ticking Time Bomb of the Eye Open
Retinal arterial macroaneurysms are acquired, focal dilation of a retinal artery. Patients with retinal arterial macroaneurysms can present with an acute or gradual loss of vision as a result of vitreous hemorrhage, preretinal hemorrhage o…
View article: Progeria Presenting with Pyogenic Granuloma in Conjunctiva: A Case Report
Progeria Presenting with Pyogenic Granuloma in Conjunctiva: A Case Report Open
Hutchinson-Gilford progeria syndrome frequently exhibits stunted growth and premature ageing. Notable ocular characteristics can encompass a large number of ocular abnormalities. Here, we report a case of a 17-year-old female who presented…
View article: Rise of biologics in noninfectious uveitis: a retrospective cohort study from Nepal
Rise of biologics in noninfectious uveitis: a retrospective cohort study from Nepal Open
Background: Uveitis is a sight-threatening disease that poses a heavy burden on the quality of life. The treatment of uveitis has been revolutionized in the past two decades. Most remarkable among these is the emergence of biologics, which…
View article: Role of multimodal imaging in differentiating unilateral APMPPE from unilateral Harada disease – a case report
Role of multimodal imaging in differentiating unilateral APMPPE from unilateral Harada disease – a case report Open
Introduction and importance: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is classified as a part of the spectrum of the white dot syndromes affecting the inner choroid and the outer retina. It is usually bilateral an…
View article: The second wave of COVID-19 wreaked havoc: A look at clinical and laboratory parameters of survivors and non-survivors admitted to Intensive Care Unit, a single-centered retrospective study
The second wave of COVID-19 wreaked havoc: A look at clinical and laboratory parameters of survivors and non-survivors admitted to Intensive Care Unit, a single-centered retrospective study Open
A BSTRACT Background: The second wave of COVID-19 was disastrous and claimed many lives in India and abroad. The most challenging task was to provide the required treatment as per the patient’s condition, within a limited span of time. The…
View article: Purtscher-like retinopathy with serous macular detachment in a case of acute pancreatitis: A case report
Purtscher-like retinopathy with serous macular detachment in a case of acute pancreatitis: A case report Open
A 28-year-old male hospitalized with a diagnosis of acute pancreatitis presented with sudden onset of blurred vision in both eyes after 48 h of admission. Visual acuity was counting fingers in both eyes. Fundus examination revealed multipl…
View article: Targeting neuroinflammation by pharmacologic down-regulation of inflammatory pathways is neuroprotective in protein misfolding disorders
Targeting neuroinflammation by pharmacologic down-regulation of inflammatory pathways is neuroprotective in protein misfolding disorders Open
Neuroinflammation plays a crucial role in the development of neurodegenerative protein misfolding disorders. This category of progressive diseases includes, but is not limited to, Alzheimer’s disease, Parkinson’s disease, and prion disease…