Explanipedia

Sanctuary sites in cortical stroke Open

Tharani Thirugnanachandran, Henry Ma, Jason Vuong, Shaloo Singhal, Lee‐Anne Slater , et al. · 2025

Comparison of Dual Antiplatelet Therapies for Minor, Nondisabling, Acute Ischemic Stroke: A Bayesian Network Meta-Analysis Open

Andy Lim, Henry Ma, John Ly, Shaloo Singhal, Yuesong Pan , et al. · 2024

Importance Dual antiplatelet therapy (DAPT) appears to be an effective treatment option for minor (nondisabling) acute ischemic stroke. This conclusion is based on trials that include both transient ischemic attack (TIA) and minor stroke; …

Osteoporosis and fracture risk assessment in adults with ischaemic stroke Open

B. Liu, Chrislyn Yan Ng, Paul Bao Duy La, Phillip Wong, Peter R. Ebeling , et al. · 2024

The FRAC-stroke score is a simple clinical tool that can be used to identify patients at high risk of fracture post-stroke who would most benefit from osteoporosis therapy. Stroke is a risk factor for fracture due to immobilisation, vitami…

Ninety‐Day Stroke Recurrence in Minor Stroke: Systematic Review and Meta‐Analysis of Trials and Observational Studies Open

Andy Lim, Henry Ma, S. Claiborne Johnston, Shaloo Singhal, Subramanian Muthusamy , et al. · 2024

Background Risk of recurrence after minor ischemic stroke is usually reported with transient ischemic attack. No previous meta‐analysis has focused on minor ischemic stroke alone. The objective was to evaluate the pooled proportion of 90‐d…

Rapid outpatient transient ischemic attack clinic and stroke service activity during the SARS-CoV-2 pandemic: a multicenter time series analysis Open

Andy Lim, Peter M. Rothwell, Linxin Li, Shelagh B. Coutts, Michael D. Hill , et al. · 2024

Background and aim Rapid outpatient evaluation and treatment of TIA in structured clinics have been shown to reduce stroke recurrence. It is unclear whether short-term downtrends in TIA incidence and admissions have had enduring impact on …

Estimating the cost of visiting hospital outpatient Open

Manoj Liyana Arachige, Wai Chung Tse, Roland Zhang, Henry Ma, Shaloo Singhal , et al. · 2024

Objectives This study aims to investigate the cost incurred by people travelling to the neurology outpatient clinic of a large metropolitan hospital. As outpatients are a substantial portion of a hospital’s demographic, we aimed to underst…

Corrigendum: Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT) Open

Thanh G. Phan, Rebecca Lim, Mirja Krause, Siow Teng Chan, Hannah McDonald , et al. · 2023

[This corrects the article DOI: 10.3389/fnins.2023.1153231.].

Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT) Open

Thanh G. Phan, Rebecca Lim, Siow Teng Chan, Hannah McDonald, Poh‐Yi Gan , et al. · 2023

Background We proposed a Phase I dose escalation trial to assess the safety of allogeneic human amniotic epithelial cells (hAECs) in stroke patients with a view to informing the design for a Phase II trial. Methods The design is based on 3…

Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events Open

Thanh N. Nguyen, Muhammad M. Qureshi, Piers Klein, Hiroshi Yamagami, Robert Mikulík , et al. · 2022

This study is registered under NCT04934020.

Clinical Outcomes and Patient Safety of Nasogastric Tube in Acute Stroke Patients Open

Jodie Rabaut, Tharani Thirugnanachandran, Shaloo Singhal, Julie Martin, Svitlana Iievliev , et al. · 2022

Topographic Evolution of Anterior Cerebral Artery Infarction and Its Impact on Motor Impairment Open

Tharani Thirugnanachandran, Henry Ma, Jason Vuong, Melissa Mitchell, Chloe Wong , et al. · 2021

Introduction: Motor deficit is common following anterior cerebral artery (ACA) stroke. This study aimed to determine the impact on the motor outcome, given the location of descending corticofugal fiber tracts (from the primar…

Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis Open

Isabel C. Hostettler, Duncan Wilson, Catherine Arnold Fiebelkorn, Diane J. Aum, Sebastián F. Ameriso , et al. · 2021

Network Mapping of Time to Antithrombotic Therapy Among Patients With Ischemic Stroke and Transient Ischemic Attack (TIA) Open

Thanh G. Phan, Benjamin Clissold, Shaloo Singhal, John Ly, Andy Lim , et al. · 2021

Background: There is emphasis on timely administration of thrombolysis and clot retrieval but not antithrombotic therapy within 48 h for ischemic stroke (frequency of 64% in Australia and 97% in North America). We planned to assess the tim…

An International Report on the Adaptations of Rapid Transient Ischaemic Attack Pathways During the COVID-19 Pandemic Open

Andy Lim, Shaloo Singhal, Philippa C. Lavallée, Pierre Amarenco, Peter M. Rothwell , et al. · 2020

Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE) Open

Shahram Abootalebi, Benjamin M. Aertker, Mohammad Sobhan Sheikh Andalibi, Negar Asdaghi, Özlem Aykaç , et al. · 2020

Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data Open

Bruce Campbell, Henry Ma, Peter A. Ringleb, Mark Parsons, Leonid Churilov , et al. · 2019

Stroke Severity Versus Dysphagia Screen as Driver for Post-stroke Pneumonia Open

Thanh G. Phan, Talvika Kooblal, Chelsea Matley, Shaloo Singhal, Benjamin Clissold , et al. · 2019

Background and Purpose: Post-stroke pneumonia is a feared complication of stroke as it is associated with greater mortality and disability than in those without pneumonia. Patients are often kept "Nil By Mouth" (NBM) after stroke un…

Exploratory Use of Decision Tree Analysis in Classification of Outcome in Hypoxic–Ischemic Brain Injury Open

Thanh G. Phan, Jian Chen, Shaloo Singhal, Henry Ma, Benjamin Clissold , et al. · 2018

Our findings provide proof of concept for further exploration of the role of MR imaging and decision tree analysis in the early prognostication of hypoxic ischemic brain injury.

Googling Service Boundaries for Endovascular Clot Retrieval Hub Hospitals in a Metropolitan Setting Open

Thanh G. Phan, Richard Beare, Jian Chen, Benjamin Clissold, John Ly , et al. · 2017

Background and Purpose— There is great interest in how endovascular clot retrieval hubs provide services to a population. We applied a computational method to objectively generate service boundaries for such endovascular clot retrieval hub…

Examining Subcortical Infarcts in the Era of Acute Multimodality CT Imaging Open

Mindy Y. Q. Tan, Shaloo Singhal, Henry Ma, Ronil V. Chandra, Jamie Cheong , et al. · 2016

Diverse stroke mechanisms were present among subcortical infarcts in different locations. When available acute CTP/CTA should be combined with subacute imaging of subcortical infarct to separate "lacunar phenotype" from those with lacunar …

Prevalence of Brain MRI Markers of Hemorrhagic Risk in Patients with Stroke and Atrial Fibrillation Open

Christopher Karayiannis, Cathy Soufan, Ronil V. Chandra, Thanh G. Phan, Kitty Wong , et al. · 2016

Multiple CMBs, severe WML, and severe cerebral atrophy were common individually in hospitalized patients with stroke and AF, but less so in combination. A higher burden of CMBs may be associated with intracerebral hemorrhage in stroke pati…

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