S. Sunder
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View article: Fluoride export is required for the competitive fitness of pathogenic microorganisms in dental biofilm models
Fluoride export is required for the competitive fitness of pathogenic microorganisms in dental biofilm models Open
Microorganisms resist fluoride toxicity using fluoride export proteins from one of several different molecular families. Cariogenic species Streptococcus mutans and Candida albicans extrude intracellular fluoride using a CLC F F - /H + ant…
View article: Fluoride export is required for competitive fitness of pathogenic microorganisms in dental biofilm models
Fluoride export is required for competitive fitness of pathogenic microorganisms in dental biofilm models Open
Microorganisms resist fluoride toxicity using fluoride export proteins from one of several different molecular families. Cariogenic species Streptococcus mutans and Candida albicans extrude intracellular fluoride using a CLC F F − /H + ant…
View article: The yeast AMP-activated protein kinase Snf1 phosphorylates the inositol polyphosphate kinase Kcs1
The yeast AMP-activated protein kinase Snf1 phosphorylates the inositol polyphosphate kinase Kcs1 Open
The yeast Snf1/AMP-activated kinase (AMPK) maintains energy homeostasis, controlling metabolic processes and glucose derepression in response to nutrient levels and environmental cues. Under conditions of nitrogen or glucose limitation, Sn…
View article: A Comparison Between the Effects of Calcium Acetate and Sevelamer Carbonate on Progression of Aortic Vascular Calcification in Patients with Chronic Kidney Disease Stages 4 and 5
A Comparison Between the Effects of Calcium Acetate and Sevelamer Carbonate on Progression of Aortic Vascular Calcification in Patients with Chronic Kidney Disease Stages 4 and 5 Open
Background: Calcium-based and non-calcium-based phosphate binders are frequently used to treat hyperphosphatemia in patients with chronic kidney disease (CKD). Objectives: This study aimed to compare the effects of calcium acetate and seve…
View article: CTEV: Pre-natal diagnosis and its impact of treatment
CTEV: Pre-natal diagnosis and its impact of treatment Open
CTEV (congenital Talipes Equinovarus) is one of the common musculo skeletal deformities in new born. The incidence is about 1/1000 population. Prenatal diagnosis is possible many times in TIFFA scan (Targeted Imaging for Fetal Anomalies). …
View article: Prevalence of Vascular Calcification in Chronic Kidney Disease Stage 4 and 5 Patients and its Correlation with Inflammatory Markers of Atherosclerosis
Prevalence of Vascular Calcification in Chronic Kidney Disease Stage 4 and 5 Patients and its Correlation with Inflammatory Markers of Atherosclerosis Open
Vascular calcification is one of the independent risk factors associated with cardiovascular disease (CVD) in chronic kidney disease (CKD) patients. This study evaluated the prevalence of vascular calcification in Indian patients with CKD …
View article: RONC-23. NOVEL APPROACH TO REDUCE ACUTE ESOPHAGEAL TOXICITY IN CRANIO-SPINAL IRRADIATION USING INTENSITY MODULATED PROTON THERAPY
RONC-23. NOVEL APPROACH TO REDUCE ACUTE ESOPHAGEAL TOXICITY IN CRANIO-SPINAL IRRADIATION USING INTENSITY MODULATED PROTON THERAPY Open
INTRODUCTION We present our experience of a novel approach using intensity modulated proton therapy(IMPT) for cranio-spinal irradiation(CSI) leading to reduced acute esophageal toxicity and reduced treatment interruptions. MATERIAL AND MET…
View article: The Ability of Novel Urinary Biomarkers (NGAL and IL-18) in Predicting the in-Hospital Mortality, the Need of Renal Replacement Therapy and the Future Development of Chronic Kidney Disease in Post-Cardiac Surgery Acute Kidney Injury Patients: A New Horizon of Hope on the Anvil
The Ability of Novel Urinary Biomarkers (NGAL and IL-18) in Predicting the in-Hospital Mortality, the Need of Renal Replacement Therapy and the Future Development of Chronic Kidney Disease in Post-Cardiac Surgery Acute Kidney Injury Patients: A New Horizon of Hope on the Anvil Open
Background: Novel urinary biomarkers have always remained/continue to remain a fascinating area of exploration in the domain of modern nephrology.They are promisingly convincing in obviating the major disadvantages of creatinine in the set…
View article: SAT-270 Results from the Chronic Kidney Disease Observational Database (CKDOD), India
SAT-270 Results from the Chronic Kidney Disease Observational Database (CKDOD), India Open
Protein restricted diets (PRD) with or without ketoanalogue (KA) supplementation are an established treatment option in chronic kidney disease (CKD). Although their efficacy for slowing down decline of CKD has been shown in randomized cont…
View article: Frequency of DNA end joining <i>in trans</i> is not determined by the predamage spatial proximity of double-strand breaks in yeast
Frequency of DNA end joining <i>in trans</i> is not determined by the predamage spatial proximity of double-strand breaks in yeast Open
Significance DNA double-strand breaks (DSBs) are severe insults that lead to different types of genome rearrangements if repaired incorrectly. We explored the genesis of genomic rearrangements mediated by the nonhomologous end-joining path…
View article: Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining
Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining Open
Non-homologous end joining (NHEJ) is the main repair pathway for DNA double-strand breaks (DSBs) in cells with limited 5' resection. To better understand how overhang polarity of chromosomal DSBs affects NHEJ, we made site-specific 5'-over…
View article: Evaluation of Protein-Energy Wasting and Inflammation on Patients Undergoing Continuous Ambulatory Peritoneal Dialysis and its Correlations
Evaluation of Protein-Energy Wasting and Inflammation on Patients Undergoing Continuous Ambulatory Peritoneal Dialysis and its Correlations Open
Protein-energy wasting (80% - 85%) by various methods and inflammation (70%) was very prevalent among patients undergoing CAPD. Inflammatory markers show significant negative correlation with anthropometry and serological markers. Inflamma…
View article: Autophosphorylation of the Smk1 MAPK is spatially and temporally regulated by Ssp2 during meiotic development in yeast
Autophosphorylation of the Smk1 MAPK is spatially and temporally regulated by Ssp2 during meiotic development in yeast Open
Smk1 is a meiosis-specific MAPK that controls spore wall morphogenesis in Saccharomyces cerevisiae. Although Smk1 is activated by phosphorylation of the threonine (T) and tyrosine (Y) in its activation loop, it is not phosphorylated by a d…
View article: A rare case of type-I auto-immune hepatitis and thyroiditis presenting with crescentic glomerulonephritis
A rare case of type-I auto-immune hepatitis and thyroiditis presenting with crescentic glomerulonephritis Open
A middle-aged female patient with a past history of non-alcoholic liver disease and hypothyroidism presented with swelling of the body, off and on, for six months and rapidly worsening renal function. Renal biopsy showed crescentic glomeru…