Longshan Zhao
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View article: Determination of genotoxic impurity in the bulk drug of crizotinib by high performance liquid chromatography-electrospray ionization tandem mass spectrometry
Determination of genotoxic impurity in the bulk drug of crizotinib by high performance liquid chromatography-electrospray ionization tandem mass spectrometry Open
A method based on high performance liquid chromatography-electrospray ionization tandem mass spectrometry （HPLC-ESI-MS/MS） was developed for the determination of the potential genotoxic impurity （WHT1408-Q2H） in the bulk drug of crizotinib…
View article: A small molecule esculetin accelerates postprandial lipid clearance involving activation of C/EBPβ and CD36-mediated phagocytosis by adipose tissue macrophages
A small molecule esculetin accelerates postprandial lipid clearance involving activation of C/EBPβ and CD36-mediated phagocytosis by adipose tissue macrophages Open
Rationale: Adipose tissue buffers dietary lipids to maintain postprandial lipid homeostasis. Adipose tissue macrophages (ATMs) mediate the phagocytosis of postprandial lipids from the exogenous diet, generating high-density lipoprot…
View article: Nitrogen-Silicon Co-Doped Carbon Dots Synthesized Based on Lemon Peel for Copper (Ii) Detection Via a Dynamic Quenching Mechanism
Nitrogen-Silicon Co-Doped Carbon Dots Synthesized Based on Lemon Peel for Copper (Ii) Detection Via a Dynamic Quenching Mechanism Open
View article: Green Biosynthesized High Quantum Yield Carbon Quantum Dots from Lotus Seed Cores for Sensitive Folic Acid Detection and Advanced Bioimaging Applicationsgreen Biosynthesized High Quantum Yield Carbon Quantum Dots from Lotus Seed Cores for Sensitive Folic Acid Detection and Advanced Bioimaging Applications
Green Biosynthesized High Quantum Yield Carbon Quantum Dots from Lotus Seed Cores for Sensitive Folic Acid Detection and Advanced Bioimaging Applicationsgreen Biosynthesized High Quantum Yield Carbon Quantum Dots from Lotus Seed Cores for Sensitive Folic Acid Detection and Advanced Bioimaging Applications Open
View article: A Bifunctional Fluorescence Probe Based on AIE-ICT Strategy for Visual Detection of Cu2+/Co2+ in Complex Matrix
A Bifunctional Fluorescence Probe Based on AIE-ICT Strategy for Visual Detection of Cu2+/Co2+ in Complex Matrix Open
A novel fluorescence chemical sensor-based probe 1-{[(E)-(2-aminophenyl)azanylidene]methyl}naphthalen-2-ol (AMN) was designed and synthesized, which performed a “naked eye” detection ability toward Cu2+ and Co2+ based on aggregation-induce…
View article: An environment-friendly approach using deep eutectic solvent combined with liquid–liquid microextraction based on solidification of floating organic droplets for simultaneous determination of preservatives in beverages
An environment-friendly approach using deep eutectic solvent combined with liquid–liquid microextraction based on solidification of floating organic droplets for simultaneous determination of preservatives in beverages Open
A green ultrasound-assisted deep eutectic solvent extraction combined with LLME-SFO method was developed and validated for the determination of preservatives in beverages.
View article: Green Extraction of Five Active Components and Their Antioxidant and Antibacterial Activities From Paeonia Lactiflora Based on Ultrasound-assisted Natural Deep Eutectic Solvents
Green Extraction of Five Active Components and Their Antioxidant and Antibacterial Activities From Paeonia Lactiflora Based on Ultrasound-assisted Natural Deep Eutectic Solvents Open
View article: A Hydrothermal Method to Generate Carbon Quantum Dots from Waste Bones and Their Detection of Laundry Powder
A Hydrothermal Method to Generate Carbon Quantum Dots from Waste Bones and Their Detection of Laundry Powder Open
Surfactants are one of the major pollutants in laundry powder, which have an impact on the environment and human health. Carbon quantum dots (CQDs) are spherical zero-dimensional fluorescent nanoparticles with great potential for fluoresce…
View article: Carbon quantum dots from biomass cicada sloughs as fluorescent probes for detection of enrofloxacin in aquatic products
Carbon quantum dots from biomass cicada sloughs as fluorescent probes for detection of enrofloxacin in aquatic products Open
Enrofloxacin (ENR) is a widely used antibiotic because of its strong bactericidal effect. However, excessive use of ENR can harm the human body and the ecological environment. Therefore, it is necessary to develop a detection method. Here,…
View article: A Visible Light-Response La-Doped Mnin2s4 with Enhanced Performance for Removing Tetracycline Hydrochloride and Triphenylmethane Dyes in Wastewater
A Visible Light-Response La-Doped Mnin2s4 with Enhanced Performance for Removing Tetracycline Hydrochloride and Triphenylmethane Dyes in Wastewater Open
View article: Preparation of Carbon Quantum Dots From Tobacco Leaves And Itsapplication For Fluorescence Detection of Borax In Flour and its Products
Preparation of Carbon Quantum Dots From Tobacco Leaves And Itsapplication For Fluorescence Detection of Borax In Flour and its Products Open
View article: Preparation of Carbon Quantum Dots From Tobacco Leaves And Itsapplication For Fluorescence Detection of Borax In Flour and its Products
Preparation of Carbon Quantum Dots From Tobacco Leaves And Itsapplication For Fluorescence Detection of Borax In Flour and its Products Open
View article: Magnetic solid-phase extraction based on multi-walled carbon nanotubes combined ferroferric oxide nanoparticles for the determination of five heavy metal ions in water samples by inductively coupled plasma mass spectrometry
Magnetic solid-phase extraction based on multi-walled carbon nanotubes combined ferroferric oxide nanoparticles for the determination of five heavy metal ions in water samples by inductively coupled plasma mass spectrometry Open
An excellent magnetic multi-walled carbon nanotubes (MMWCNT) containing carboxyl material modified with ferroferric oxide (Fe3O4) nanoparticles was synthesized as the adsorbent for magnetic solid-phase extraction (MSPE) of five heavy metal…
View article: 基于低共熔溶剂的萃取分离技术及其应用研究进展
基于低共熔溶剂的萃取分离技术及其应用研究进展 Open
With the rapid development of green chemistry, the design and application of the related methods and requisite solvents have received increasing attention in recent years. Deep eutectic solvents (DESs) are mixtures formed from a hydrogen b…
View article: Natural deep eutectic solvents as tailored and sustainable media for the extraction of five compounds from compound liquorice tablets and their comparison with conventional organic solvents
Natural deep eutectic solvents as tailored and sustainable media for the extraction of five compounds from compound liquorice tablets and their comparison with conventional organic solvents Open
A 1,4-butanediol–levulinic acid system was selected as a topgallant solvent and extraction parameters were optimized. NADES extracts exhibited higher extraction efficiency and in vitro antioxidant activities than conventional solvent extra…
View article: Ratiometric fluorescence probe of Cu<sup>2+</sup> and biothiols by using carbon dots and copper nanoclusters
Ratiometric fluorescence probe of Cu<sup>2+</sup> and biothiols by using carbon dots and copper nanoclusters Open
A dual-mechanism ratiometric fluorescent probe based on N-doped yellow fluorescent carbon dots (y-CDs) and blue fluorescent copper nanoclusters (CuNCs) was established for the first simultaneous determination of Cu 2+ and biothiols.
View article: Mechanisms Exploration of Terrestrosin D on Pulmonary Fibrosis Based on Plasma Metabonomics and Network Pharmacology
Mechanisms Exploration of Terrestrosin D on Pulmonary Fibrosis Based on Plasma Metabonomics and Network Pharmacology Open
View article: Determination of Antioxidant 264 in the Butyl Rubber Stopper and the Compatibility with Recombinant Potent Antitumor and Antivirus Protein Injection
Determination of Antioxidant 264 in the Butyl Rubber Stopper and the Compatibility with Recombinant Potent Antitumor and Antivirus Protein Injection Open
Objective . To establish a method for extraction and determination of antioxidant 264 (2,6-di-tert-butyl-4-methylphenol) in the brominated butyl rubber stopper for injection and migration study in recombinant potent antitumor and antivirus…
View article: A carbon nanoparticle-peptide fluorescent sensor custom-made for simple and sensitive detection of trypsin
A carbon nanoparticle-peptide fluorescent sensor custom-made for simple and sensitive detection of trypsin Open
View article: Compatibility of rubber stoppers for recombinant antitumor-antivirus protein injection by gas chromatography-mass spectrometry
Compatibility of rubber stoppers for recombinant antitumor-antivirus protein injection by gas chromatography-mass spectrometry Open
View article: Study on degradation kinetics of epalrestat in aqueous solutions and characterization of its major degradation products under stress degradation conditions by UHPLC-PDA-MS/MS
Study on degradation kinetics of epalrestat in aqueous solutions and characterization of its major degradation products under stress degradation conditions by UHPLC-PDA-MS/MS Open
Drug stability is closely related to drug safety and needs to be considered in the process of drug production, package and storage. To investigate the stability of epalrestat, a carboxylic acid derivative, a reversed-phase high-performance…
View article: Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis
Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis Open
View article: Identification of the cytochrome P450 enzymes involved in the oxidative metabolism of trantinterol using ultra high-performance liquid chromatography coupled with tandem mass spectrometry
Identification of the cytochrome P450 enzymes involved in the oxidative metabolism of trantinterol using ultra high-performance liquid chromatography coupled with tandem mass spectrometry Open
The first report on the characterization of the main CYP450 enzymes and the kinetic study involved in trantinterol metabolism.
View article: Tissue metabolomic profiling to reveal the therapeutic mechanism of reduning injection on LPS-induced acute lung injury rats
Tissue metabolomic profiling to reveal the therapeutic mechanism of reduning injection on LPS-induced acute lung injury rats Open
A metabolomic strategy has been developed to investigate the therapeutic mechanistic insights of RDN on the ALI.
View article: Simultaneous Determination of Vinpocetine and its Major Active Metabolite Apovincaminic Acid in Rats by UPLC-MS/MS and its Application to the Brain Tissue Distribution Study
Simultaneous Determination of Vinpocetine and its Major Active Metabolite Apovincaminic Acid in Rats by UPLC-MS/MS and its Application to the Brain Tissue Distribution Study Open
A specific, rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method was developed for simultaneous determination of vinpocetine (VP) and its active metabolite, apovincaminic acid (AVA) in r…
View article: Ionic liquid-based dispersive liquid-liquid microextraction combined with functionalized magnetic nanoparticle solid-phase extraction for determination of industrial dyes in water
Ionic liquid-based dispersive liquid-liquid microextraction combined with functionalized magnetic nanoparticle solid-phase extraction for determination of industrial dyes in water Open
N-butyl pyridinium bis((trifluoromethyl)sulfonyl)imide ([Hpy]NTf 2 ) functionalized core/shell magnetic nanoparticles (MNPs, Fe 3 O 4 @SiO 2 @[Hpy]NTf 2 )) were prepared and applied as an adsorbent for magnetic solid phase extraction (MSPE…
View article: Development of a UPLC–MS/MS method for determination of pimavanserin tartrate in rat plasma: Application to a pharmacokinetic study
Development of a UPLC–MS/MS method for determination of pimavanserin tartrate in rat plasma: Application to a pharmacokinetic study Open
A simple, rapid and sensitive method based on an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed and validated for the determination of pimavanserin in rat plasma. The analyte was extracted …
View article: Comparative Pharmacokinetics and Bioavailability of Three Ephedrines in Rat after Oral Administration of Unprocessed and Honey‐Fried Ephedra Extract by Response Surface Experimental Design
Comparative Pharmacokinetics and Bioavailability of Three Ephedrines in Rat after Oral Administration of Unprocessed and Honey‐Fried Ephedra Extract by Response Surface Experimental Design Open
Ephedra have been used as a common traditional Chinese medicine for thousands of years. However, the perspiration effect of the unprocessed ephedra was too strong. Clinical trials have shown that processing methods play a critical role in …
View article: Simultaneous determination of topiramate, carbamazepine, oxcarbazepine and its major metabolite in human plasma by SFC-ESI-MS/MS with polarity switching: Application to therapeutic drug monitoring
Simultaneous determination of topiramate, carbamazepine, oxcarbazepine and its major metabolite in human plasma by SFC-ESI-MS/MS with polarity switching: Application to therapeutic drug monitoring Open
Antiepileptic drugs are the first choice for epilepsy treatment. Monitoring antiepileptic drugs is important to minimize their adverse side effects by choosing the optimum drug dosage. An accurate and high throughput supercritical fluid ch…
View article: Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS
Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS Open
The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats. A simple and efficient high performance liquid …