Shane A. Landry
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View article: The effect of non-sedative/hypnotic treatment of obstructive sleep apnoea on the respiratory arousal threshold: a systematic review and meta-analysis
The effect of non-sedative/hypnotic treatment of obstructive sleep apnoea on the respiratory arousal threshold: a systematic review and meta-analysis Open
Contrary to the view that a lower arousal threshold causes greater susceptibility to obstructive sleep apnoea (OSA), the arousal threshold has been shown to decrease following treatment with continuous positive airway pressure (CPAP) thera…
View article: Patient-reported preferences for sleep apnoea treatments in an Australian community sample
Patient-reported preferences for sleep apnoea treatments in an Australian community sample Open
Our findings provide clear evidence for patient preference and acceptability of medication or nasal spray alternative therapies for OSA among patients in Australia. Side effect profiles have a large effect on tolerability ratings.
View article: Schlafapnoe-Endotypen und ihre Bedeutung für die klinische Praxis
Schlafapnoe-Endotypen und ihre Bedeutung für die klinische Praxis Open
Obstruktive Schlafapnoe (OSA) gilt heute als multifaktorielle Erkrankung, die durch mehrere Endotypen verursacht wird, die sich zwischen einzelnen Personen und Patientengruppen unterscheiden. Um die aktuellen klinischen Implikationen von O…
View article: P084 Does OSA endotype impact the incidence of atrial fibrillation and the severity of atrial remodelling? A retrospective cohort study.
P084 Does OSA endotype impact the incidence of atrial fibrillation and the severity of atrial remodelling? A retrospective cohort study. Open
Background Multiple studies have suggested that the prevalent sleep disorder obstructive sleep apnoea (OSA) plays a key role in initiating and progressing atrial fibrillation (AF) as well as impacting the response to arrhythmia pharmaco- a…
View article: P048 The impact of variability in sleep scoring between manual and autoscoring on the measurement of OSA endotypes
P048 The impact of variability in sleep scoring between manual and autoscoring on the measurement of OSA endotypes Open
Background Obstructive Sleep Apnoea (OSA) endotypic traits can be quantified using signals from routine polysomnography (PSG). However, it is unclear whether interrater variability in manual and auto sleep scoring influences the measuremen…
View article: P046 Symptom subtypes of obstructive sleep apnoea determined using latent class analysis have distinct comorbidity profiles
P046 Symptom subtypes of obstructive sleep apnoea determined using latent class analysis have distinct comorbidity profiles Open
Background Three clinical phenotypes of obstructive sleep apnoea (OSA) were first described in the Icelandic Sleep Apnoea Cohort, with later studies reporting between 3-5 subtypes. We aimed to determine the optimal clustering of OSA phenot…
View article: O056 OSA in Pacific islanders: distinct endotypes and increased hypoxic burden
O056 OSA in Pacific islanders: distinct endotypes and increased hypoxic burden Open
Introduction Obstructive sleep apnoea (OSA) is more prevalent in Pacific Islanders (PI); however, the pathophysiological mechanisms are unknown. We compared OSA endotypes of PI with Caucasians (C) in a sleep clinic population. Methods PI w…
View article: Mitochondria-derived peptide MOTS-c and its role in OSA pathogenesis: a potential therapeutic target?
Mitochondria-derived peptide MOTS-c and its role in OSA pathogenesis: a potential therapeutic target? Open
View article: The impact of acetazolamide and dronabinol on the physiological endotypes responsible for obstructive sleep apnea
The impact of acetazolamide and dronabinol on the physiological endotypes responsible for obstructive sleep apnea Open
Mechanistically, our findings suggest that medium and high doses of Aceta-Dro primarily reduce OSA severity by lowering loop gain, while the efficacy of the low dose was due to improved airway collapsibility.
View article: International stakeholder engagement on clinical care and research for nocturnal hypoxaemia in pulmonary fibrosis
International stakeholder engagement on clinical care and research for nocturnal hypoxaemia in pulmonary fibrosis Open
Background Nocturnal hypoxaemia is common in people with pulmonary fibrosis (PF). This study aimed to explore current practice and establish global perspective on research priorities and outcome measures of importance in sleep assessment a…
View article: The effect of M‐current activation on controller gain and obstructive sleep apnoea severity: a randomised controlled trial using flupirtine
The effect of M‐current activation on controller gain and obstructive sleep apnoea severity: a randomised controlled trial using flupirtine Open
Ventilatory control instability, or high loop gain (LG), contributes towards upper airway collapse in approximately one‐third of people with obstructive sleep apnoea (OSA). A high LG can be the product of elevated chemosensitivity (control…
View article: Ultraviolet radiation vs air filtration to mitigate virus laden aerosol in an occupied clinical room
Ultraviolet radiation vs air filtration to mitigate virus laden aerosol in an occupied clinical room Open
Mitigation measures against infectious aerosols are desperately needed. We aimed to: 1) compare germicidal ultraviolet radiation (GUV) at 254 nm (254-GUVUpper-Room) and 222 nm (222-GUVWhole-Room) with portable high ef…
View article: Pulmonary Embolism Post‐Bioprosthetic Aortic Valve Replacement: A Case Report
Pulmonary Embolism Post‐Bioprosthetic Aortic Valve Replacement: A Case Report Open
Pulmonary embolism is a rare complication post‐bioprosthetic valve replacement, which is seldom reported in the literature. Case Description: A 76‐year‐old woman was admitted to our institution with a diagnosis of pulmonary embolism, occur…
View article: Sleep apnea endotypes and their implications for clinical practise
Sleep apnea endotypes and their implications for clinical practise Open
Obstructive sleep apnea (OSA) is now recognized to be a multifactorial disorder caused by several endotypes that differ between individuals and patient populations. In order to understand the current clinical implications of OSA endotypes,…
View article: The Arousal Threshold: The “Weakest Link” in Obstructive Sleep Apnea Pathogenesis?
The Arousal Threshold: The “Weakest Link” in Obstructive Sleep Apnea Pathogenesis? Open
View article: O063 Cognitive behavioural therapy for insomnia improves obstructive sleep apnoea severity, but not any of the endotype traits in those with comorbid insomnia and sleep apnoea (COMISA)
O063 Cognitive behavioural therapy for insomnia improves obstructive sleep apnoea severity, but not any of the endotype traits in those with comorbid insomnia and sleep apnoea (COMISA) Open
Background Evidence suggests cognitive behavioural therapy for insomnia (CBT-I) improves obstructive sleep apnoea (OSA) severity in those with comorbid insomnia and sleep apnoea (COMISA), though the mechanisms behind this change are unstud…
View article: Ultraviolet Radiation vs Air Filtration to Mitigate Virus Laden Aerosol in an Occupied Clinical Room
Ultraviolet Radiation vs Air Filtration to Mitigate Virus Laden Aerosol in an Occupied Clinical Room Open
View article: Is snoozing losing? Why intermittent morning alarms are used and how they affect sleep, cognition, cortisol, and mood
Is snoozing losing? Why intermittent morning alarms are used and how they affect sleep, cognition, cortisol, and mood Open
Summary Pressing the snooze button is a common way to start the day, but little is known about this behaviour. Through two studies we determined predictors and effects of snoozing. In Study 1 ( n = 1732) respondents described their waking …
View article: P024 The Obstructive Sleep Apnoea Endotypes are Similar in Elderly Veterans with and without PTSD.
P024 The Obstructive Sleep Apnoea Endotypes are Similar in Elderly Veterans with and without PTSD. Open
Background Approximately 60% of veterans living with post-traumatic stress disorder (PTSD) experience obstructive sleep apnoea (OSA). Why OSA is so prevalent in individuals with PTSD remains unknown, though the presence of PTSD may influen…
View article: O057 The Impact of Surgical Weight Loss on the Physiological Endotypes causing Obstructive Sleep Apnea
O057 The Impact of Surgical Weight Loss on the Physiological Endotypes causing Obstructive Sleep Apnea Open
Background Weight loss improves upper airway collapsibility in people with obstructive sleep apnoea (OSA). However, it’s unclear how weight loss affects the other endotypes responsible for OSA (loop gain, arousal threshold and muscle compe…
View article: A review of supine position related obstructive sleep apnea: Classification, epidemiology, pathogenesis and treatment
A review of supine position related obstructive sleep apnea: Classification, epidemiology, pathogenesis and treatment Open
Supine related obstructive sleep apnea (OSA) is the most common clinical and physiological phenotype of OSA. This condition is recognizable by patients, their families and through polysomnographic recordings. Commonly used definitions dist…
View article: Quantifying the reduction of airborne infectious viral load using a ventilated patient hood
Quantifying the reduction of airborne infectious viral load using a ventilated patient hood Open
View article: O028 Combination Pharmacological Therapy Targeting Multiple Mechanisms of Sleep Apnea
O028 Combination Pharmacological Therapy Targeting Multiple Mechanisms of Sleep Apnea Open
Introduction Currently two leading experimental pharmacological interventions are under investigation for obstructive sleep apnea (OSA). Acetazolamide, which acts to stabilise ventilatory control, lowers the apnea-hypopnea index (AHI) by ∼…
View article: O056 The effect of acetazolamide and oxygen (ACZ+O2) combination therapy on loop gain and OSA severity
O056 The effect of acetazolamide and oxygen (ACZ+O2) combination therapy on loop gain and OSA severity Open
Introduction One third of patients with OSA have high loop gain. Acetazolamide (ACZ) and supplemental oxygen (O2) individually reduce loop gain (via different mechanisms) and the apnoea-hypopnoea-index (AHI). The current study aimed to exp…
View article: O053 Obstructive sleep apnea is a distinct physiological phenotype in individuals with comorbid insomnia and sleep apnea (COMISA)
O053 Obstructive sleep apnea is a distinct physiological phenotype in individuals with comorbid insomnia and sleep apnea (COMISA) Open
Introduction Obstructive sleep apnea (OSA) pathophysiology varies among individuals, though the influence of comorbid insomnia on this pathophysiology is unknown. We examined whether upper airway collapsibility, muscle compensation, loop g…
View article: O008 The effect of flow limited breathing and endotypes on night to night variability of sleep apnoea severity
O008 The effect of flow limited breathing and endotypes on night to night variability of sleep apnoea severity Open
Background Obstructive sleep apnoea (OSA) is a condition involving repetitive collapse of the upper airway during sleep. The diagnosis and characterisation of OSA is based primarily off the apnoea-hypopnoea index (AHI) in a single-night sl…
View article: A single dose of noradrenergic/serotonergic reuptake inhibitors combined with an antimuscarinic does not improve obstructive sleep apnoea severity
A single dose of noradrenergic/serotonergic reuptake inhibitors combined with an antimuscarinic does not improve obstructive sleep apnoea severity Open
Previous trials have demonstrated that the combination of noradrenergic reuptake inhibitors with an antimuscarinic can substantially reduce the apnoea-hypopnoea index (AHI) and improve airway collapsibility in patients with obstructive sle…
View article: Efficacy of a patient isolation hood in reducing exposure to airborne infectious virus in a simulated healthcare setting
Efficacy of a patient isolation hood in reducing exposure to airborne infectious virus in a simulated healthcare setting Open
Background Healthcare workers treating patients with SARS-CoV-2 are at risk of infection from patient-emitted virus-laden aerosols. We quantified the reduction of airborne infectious virus in a simulated hospital room when a ventilated pat…
View article: Examining the impact of multilevel upper airway surgery on the obstructive sleep apnoea endotypes and their utility in predicting surgical outcomes
Examining the impact of multilevel upper airway surgery on the obstructive sleep apnoea endotypes and their utility in predicting surgical outcomes Open
Background and objective Upper airway surgery for obstructive sleep apnoea (OSA) is an alternative treatment for patients who are intolerant of continuous positive airway pressure (CPAP). However, upper airway surgery has variable treatmen…
View article: Fit-Tested N95 Masks Combined With Portable High-Efficiency Particulate Air Filtration Can Protect Against High Aerosolized Viral Loads Over Prolonged Periods at Close Range
Fit-Tested N95 Masks Combined With Portable High-Efficiency Particulate Air Filtration Can Protect Against High Aerosolized Viral Loads Over Prolonged Periods at Close Range Open
Background Healthcare workers (HCWs) are at risk from aerosol transmission of severe acute respiratory syndrome coronavirus 2. The aims of this study were to (1) quantify the protection provided by masks (surgical, fit-testFAILED N95, fit-…