Shane Shapera
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View article: Standard pulmonary function tests and respiratory oscillometry patterns in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis
Standard pulmonary function tests and respiratory oscillometry patterns in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis Open
Background Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) caused by repeated exposure to inhaled antigens, leading to small airway and parenchymal inflammation. Diagnosis is based on a detailed clinical history, ch…
View article: Multidisciplinary Videoconferencing for Physician Education and Remote Management of Interstitial Lung Disease
Multidisciplinary Videoconferencing for Physician Education and Remote Management of Interstitial Lung Disease Open
Background: The gold standard for interstitial lung disease (ILD) diagnosis is multidisciplinary discussion (MDD); however, access is often limited by geographic barriers, time constraints, and the number of centers with ILD expertise. Obj…
View article: Managing Select Immune-Related Adverse Events in Patients Treated with Immune Checkpoint Inhibitors
Managing Select Immune-Related Adverse Events in Patients Treated with Immune Checkpoint Inhibitors Open
The increased use of immune checkpoint inhibitors (ICIs) across cancer programs has created the need for standardized monitoring and management of immune-related adverse events (irAEs). Delayed recognition without appropriate treatment can…
View article: Acute exacerbations in patients with progressive pulmonary fibrosis
Acute exacerbations in patients with progressive pulmonary fibrosis Open
Background Acute exacerbations of fibrosing interstitial lung diseases (ILDs) are associated with high mortality. We used prospective data from the INBUILD trial to investigate risk factors for acute exacerbations and the impact of these e…
View article: Impact of surgical lung biopsy on lung function and survival in patients with idiopathic pulmonary fibrosis in a multi‐centre registry cohort
Impact of surgical lung biopsy on lung function and survival in patients with idiopathic pulmonary fibrosis in a multi‐centre registry cohort Open
Background and Objective Establishing an accurate and timely diagnosis of idiopathic pulmonary fibrosis (IPF) is essential for appropriate management and prognostication. In some cases, surgical lung biopsy (SLB) is performed but carries n…
View article: The Clinical Frailty Scale for Risk Stratification in Patients With Fibrotic Interstitial Lung Disease
The Clinical Frailty Scale for Risk Stratification in Patients With Fibrotic Interstitial Lung Disease Open
The simple and practical CFS is associated with pulmonary and physical function decline in patients with fibrotic ILD and provides additional prognostic accuracy in clinical practice.
View article: Lung imaging patterns in connective tissue disease–associated interstitial lung disease impact prognosis and immunosuppression response
Lung imaging patterns in connective tissue disease–associated interstitial lung disease impact prognosis and immunosuppression response Open
Objectives Interstitial lung disease (ILD) in CTDs has highly variable morphology. We aimed to identify imaging features and their impact on ILD progression, mortality, and immunosuppression response. Methods Patients with CTD-ILD had high…
View article: Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease Open
Background Approximately 50% of patients with interstitial lung disease (ILD) experience frailty, which remains unexplored in acute exacerbations of ILD (AE-ILD). A better understanding may help with prognostication and resource planning. …
View article: Predicting New-onset Exertional and Resting Hypoxemia in Fibrotic Interstitial Lung Disease
Predicting New-onset Exertional and Resting Hypoxemia in Fibrotic Interstitial Lung Disease Open
Rationale: Hypoxemia in fibrotic interstitial lung disease (ILD) indicates disease progression and is of prognostic significance. The onset of hypoxemia signifies disease progression and predicts mortality in fibrotic ILD. Accurately predi…
View article: Managing the Risk of Lung Toxicity with Trastuzumab Deruxtecan (T-DXd): A Canadian Perspective
Managing the Risk of Lung Toxicity with Trastuzumab Deruxtecan (T-DXd): A Canadian Perspective Open
Ongoing advances in precision cancer therapy have increased the number of molecularly targeted and immuno-oncology agents for a variety of cancers, many of which have been associated with a risk of pulmonary complications, among the most c…
View article: POS0123 ASSOCIATION OF LUNG IMAGING PATTERN WITH PROGNOSIS AND IMMUNOSUPPRESSION RESPONSE IN CONNECTIVE TISSUE DISEASE ASSOCIATED INTERSTITIAL LUNG DISEASE
POS0123 ASSOCIATION OF LUNG IMAGING PATTERN WITH PROGNOSIS AND IMMUNOSUPPRESSION RESPONSE IN CONNECTIVE TISSUE DISEASE ASSOCIATED INTERSTITIAL LUNG DISEASE Open
Background Prognosis in connective tissue disease associated interstitial lung disease (CTD-ILD) is influenced by the underlying diagnosis and chest imaging pattern. Usual interstitial pneumonia (UIP), non-specific interstitial pneumonia (…
View article: Treatment of rheumatoid arthritis-associated interstitial lung disease in a multi-center registry cohort
Treatment of rheumatoid arthritis-associated interstitial lung disease in a multi-center registry cohort Open
Treatment of RA-ILD is heterogeneous, with most patients in this cohort not receiving treatment. Patients with UIP had worse outcomes compared to NSIP, similar to other cohorts. Randomized clinical trials are needed to inform pharmacologic…
View article: An unusual case of interstitial lung disease: Revisiting peribronchiolar metaplasia interstitial lung disease (<scp>PBM‐ILD</scp>)
An unusual case of interstitial lung disease: Revisiting peribronchiolar metaplasia interstitial lung disease (<span>PBM‐ILD</span>) Open
Peribronchiolar metaplasia (PBM) is a histological finding of uncertain significance commonly seen in interstitial lung disease (ILD). PBM is thought to be secondary to small airway injury from insults such as tobacco smoke and other envir…
View article: SSC/SSCS – SSP/SSTS Joint Annual Meeting 2023 - Abstracts
SSC/SSCS – SSP/SSTS Joint Annual Meeting 2023 - Abstracts Open
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View article: Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study Open
Genentech.
View article: Inhalational exposures in patients with fibrotic interstitial lung disease: Presentation, pulmonary function and survival in the <scp>Canadian Registry</scp> for <scp>Pulmonary Fibrosis</scp>
Inhalational exposures in patients with fibrotic interstitial lung disease: Presentation, pulmonary function and survival in the <span>Canadian Registry</span> for <span>Pulmonary Fibrosis</span> Open
Background and objective Inhalational exposures are a known cause of interstitial lung disease (ILD), but little is understood about their prevalence across ILD subtypes and their relationship with pulmonary function and survival. Methods …
View article: Correlation of respiratory oscillometry with CT image analysis in a prospective cohort of idiopathic pulmonary fibrosis
Correlation of respiratory oscillometry with CT image analysis in a prospective cohort of idiopathic pulmonary fibrosis Open
Background Markers of idiopathic pulmonary fibrosis (IPF) severity are based on measurements of forced vital capacity (FVC), diffusing capacity (DLCO) and CT. The pulmonary vessel volume (PVV) is a novel quantitative and independent progno…
View article: Prevalence and characteristics of progressive fibrosing interstitial lung disease in a prospective registry
Prevalence and characteristics of progressive fibrosing interstitial lung disease in a prospective registry Open
Background Progressive fibrosing interstitial lung disease (PF-ILD) is characterised by progressive physiological, symptomatic and/or radiographic worsening. The real-world prevalence and characteristics of PF-ILD remain uncertain. Methods…
View article: Validation and minimum important difference of the UCSD shortness of breath questionnaire in fibrotic interstitial lung disease
Validation and minimum important difference of the UCSD shortness of breath questionnaire in fibrotic interstitial lung disease Open
Rationale: The University of California, San Diego Shortness of Breath Questionnaire (UCSDSOBQ) is a frequently used domain-specific dyspnea questionnaire; however, there is little information available regarding its use and minimum import…
View article: Tolerability of Mycophenolate and Azathioprine in Patients with Fibrotic Interstitial Lung Disease: A Prospective Cohort Study Using Real-World Data
Tolerability of Mycophenolate and Azathioprine in Patients with Fibrotic Interstitial Lung Disease: A Prospective Cohort Study Using Real-World Data Open
Rationale: Mycophenolate (MMF) and azathioprine (AZA) are two immunosuppressive medications commonly used in patients with fibrotic interstitial lung diseases (ILDs).We sought to determine the prescribing patterns and tolerability of MMF a…
View article: Utility of anti-neutrophil cytoplasmic antibody screening in idiopathic interstitial lung disease.
Utility of anti-neutrophil cytoplasmic antibody screening in idiopathic interstitial lung disease. Open
ANCA screening in patients with idiopathic ILD rarely yields positive results. These results support an individualized approach to ANCA testing as opposed to widespread screening.