Shane Smith
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View article: Nalfurafine is Aversive at Antinociceptive Doses in Mice
Nalfurafine is Aversive at Antinociceptive Doses in Mice Open
Nalfurafine is the only clinically approved kappa opioid receptor (KOPr) agonist that can cross the blood–brain barrier and exert CNS effects. Because its clinical use is not associated with dysphoria, it is widely believed to have an atyp…
View article: Behavioral and Cellular Effects of Vitamin A Deficiency in a J20:RARE‐LacZ mouse model of Alzheimer's Disease
Behavioral and Cellular Effects of Vitamin A Deficiency in a J20:RARE‐LacZ mouse model of Alzheimer's Disease Open
Background All‐trans retinoic acid (ATRA), a metabolite of vitamin A (VA), has been shown to upregulate ADAM10, an α‐secretase enzyme responsible for non‐amyloidogenic APP cleavage by binding to promoter retinoic acid response elements (RA…
View article: The combination of all‐trans retinoic acid and Vorinostat protects neurons from oxidative stress via the Nrf2‐ARE pathway
The combination of all‐trans retinoic acid and Vorinostat protects neurons from oxidative stress via the Nrf2‐ARE pathway Open
Background A key feature of Alzheimer's disease (AD) is the accumulation of reactive oxygen species (ROS), which causes oxidative damage and mitochondrial dysfunction. Diet‐derived antioxidants such as all‐trans retinoic acid (ATRA) and ox…
View article: Examining Canadian Trauma Centres’ Analgesic Protocols for Rib Fractures
Examining Canadian Trauma Centres’ Analgesic Protocols for Rib Fractures Open
Introduction: Rib fractures are common in patients with blunt thoracic trauma, and their associated pain causes significant morbidity and mortality. Adequate analgesia is crucial to prevent rib fracture-associated pulmonary complications. …
View article: RARE‐LacZ Mice as a Model to Study of Retinoic Acid Signaling in Alzheimer’s Disease
RARE‐LacZ Mice as a Model to Study of Retinoic Acid Signaling in Alzheimer’s Disease Open
Background Disrupted balance between amyloidogenic and non‐amyloidogenic pathways leads to cognitive decline in Alzheimer’s disease (AD). Evidence suggests vitamin A (VA) supplementation favors the non‐amyloidogenic pathway through upregul…
View article: Damage-control vascular surgery in Canada: supporting surgeons and teams
Damage-control vascular surgery in Canada: supporting surgeons and teams Open
SummaryIn Canada, trauma patients often present initially to non-trauma hospitals without vascular surgeons on site. Local surgeons need skills and support for damage-control vascular surgery. Canadian training programs in general surgery …
View article: Histopathology of Hidradenitis Suppurativa: A Systematic Review
Histopathology of Hidradenitis Suppurativa: A Systematic Review Open
Hidradenitis suppurativa (HS) is a chronic inflammatory scarring disease felt to be related to occlusion of the hair follicle unit in intertriginous areas. We perform a systematic review on HS histopathology to evaluate current knowledge a…
View article: Experimental evaluation of the resolution improvement provided by a silicon PET probe
Experimental evaluation of the resolution improvement provided by a silicon PET probe Open
A high-resolution PET system, which incorporates a silicon detector probe into a conventional PET scanner, has been proposed to obtain increased image quality in a limited region of interest. Detailed simulation studies have previously sho…