Shan‐Feng Ma
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View article: Hydrogen sulfide mitigates myocardial inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation in diabetic rats
Hydrogen sulfide mitigates myocardial inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation in diabetic rats Open
Inflammation plays a crucial part in hyperglycemia-induced myocardial damage. Hydrogen sulfide has been found to possess multiple biological activities in previous studies. This study investigated whether hydrogen sulfide conferred cardiac…
View article: Exogenous H2S mitigates myocardial fibrosis in diabetic rats through suppression of the canonical Wnt pathway
Exogenous H2S mitigates myocardial fibrosis in diabetic rats through suppression of the canonical Wnt pathway Open
Hydrogen sulfide (H2S) has antifibrotic activity in the kidneys, heart, lungs, and other organs. The present study investigated the protective activity of exogenous H2S against myocardial fibrosis in a rat model of diabetes. Animals were a…
View article: Expression and localization of absent in melanoma 2 in the injured spinal cord
Expression and localization of absent in melanoma 2 in the injured spinal cord Open
In traumatic brain injury, absent in melanoma 2 (AIM2) has been demonstrated to be involved in pyroptotic neuronal cell death. Although the pathophysiological mechanism of spinal cord injury is similar to that of brain injury, the expressi…
View article: Genistein attenuates renal fibrosis in streptozotocin‑induced diabetic rats
Genistein attenuates renal fibrosis in streptozotocin‑induced diabetic rats Open
The present study aimed to investigate the antifibrogenic effects of genistein (GEN) on the kidney in streptozotocin (STZ)‑induced diabetic rats and to determine the associated mechanisms. Rats were randomized into four groups: Normal cont…
View article: Effect of genistein on myocardial fibrosis in diabetic rats and its mechanism
Effect of genistein on myocardial fibrosis in diabetic rats and its mechanism Open
The aim of the present study was to investigate the effects of genistein (GEN) on myocardial fibrosis in type 1 diabetic rats and explore the underlying mechanisms. Rats were divided into 4 groups: Normal control (N), diabetic control (D),…
View article: Effects of hydrogen sulfide on inducible nitric oxide synthase activity and expression of cardiomyocytes in diabetic rats
Effects of hydrogen sulfide on inducible nitric oxide synthase activity and expression of cardiomyocytes in diabetic rats Open
The aim of the present study was to investigate the effects of hydrogen sulfide (H2S) on the activity and expression of inducible nitric oxide synthase (iNOS) in the myocardial tissue of type 1 diabetic rats. Rats were divided randomly int…
View article: The Protective Effect of Low-Dose Ethanol on Myocardial Fibrosis through Downregulating the JNK Signaling Pathway in Diabetic Rats
The Protective Effect of Low-Dose Ethanol on Myocardial Fibrosis through Downregulating the JNK Signaling Pathway in Diabetic Rats Open
Objective . To investigate the effects of low dose ethanol feeding in diabetic rats and analyze its underlying mechanisms. Methods . Male Sprague-Dawley rats were divided into 4 groups: control (Con), diabetes at 4 weeks (DM4W), diabetes a…
View article: Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the <i>I</i><sub>to</sub> Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction
Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the <i>I</i><sub>to</sub> Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction Open
H2S targets the Cys320/Cys529 motif in Kv4.2 to regulate the Ito potassium channels. H2S also shows a potent regularizing effect against fatal arrhythmia in a rat model of myocardial infarction. The study provides the first piece of eviden…