Shang‐Tian Yang
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View article: Gut Bacteria-Based Cancer Therapy and Anti-Solid Tumor Mechanisms
Gut Bacteria-Based Cancer Therapy and Anti-Solid Tumor Mechanisms Open
Cancer constitutes a significant global health challenge, ranking among the leading contributors to worldwide mortality. The inherent limitations of conventional oncologic interventions, particularly their frequent inability to induce dura…
View article: Development of 3D Cell-Based Fluorescent Reporter Assay for Screening of Drugs Downregulating Telomerase Reverse Transcriptase
Development of 3D Cell-Based Fluorescent Reporter Assay for Screening of Drugs Downregulating Telomerase Reverse Transcriptase Open
A fluorescent cell-based assay was developed for the screening of chemicals repressing the expression of human telomerase reverse transcriptase (hTERT). hTERT is reactivated during carcinogenesis and is overexpressed in more than 90% of ca…
View article: A Perspective in Future Biomanufacturing: Challenges in Industrial Fermentation—Understanding and Controlling Microbial Lifespan and Aging
A Perspective in Future Biomanufacturing: Challenges in Industrial Fermentation—Understanding and Controlling Microbial Lifespan and Aging Open
Sancang Publishing House is mainly engaged in the publication and distribution of Chinese international open source journals. The journals cover engineering technology, mathematics and physics, humanities and society, information science, …
View article: A New Phase of Synthetic Biology and A New Journal for Its Twin with Engineering for Biomanufacturing
A New Phase of Synthetic Biology and A New Journal for Its Twin with Engineering for Biomanufacturing Open
Sancang Publishing House is mainly engaged in the publication and distribution of Chinese international open source journals. The journals cover engineering technology, mathematics and physics, humanities and society, information science, …
View article: Production of Butyric Acid from Hydrolysate of Rice Husk Treated by Alkali and Enzymes in Immobilized Fermentation by Clostridium tyrobutyricum CtΔpta
Production of Butyric Acid from Hydrolysate of Rice Husk Treated by Alkali and Enzymes in Immobilized Fermentation by Clostridium tyrobutyricum CtΔpta Open
Rice husk, as a cellulose-rich by-product in agriculture, has been considered as a low-cost substrate for the production of bioethanol and chemicals. In this study, rice husk was pretreated with an alkali, followed by cellulose and β-gluco…
View article: Antibiofilm property and multiple action of peptide PEW300 against Pseudomonas aeruginosa
Antibiofilm property and multiple action of peptide PEW300 against Pseudomonas aeruginosa Open
Pseudomonas aeruginosa ( P. aeruginosa ), an opportunistic pathogen, is often associated with difficulties in treating hospital-acquired infections. Biofilms formed by P. aeruginosa significantly improve its resistance to antimicrobial age…
View article: High-rate continuous n -butanol production by Clostridium acetobutylicum from glucose and butyric acid in a single-pass fibrous bed bioreactor
High-rate continuous n -butanol production by Clostridium acetobutylicum from glucose and butyric acid in a single-pass fibrous bed bioreactor Open
Biobutanol produced in acetone-butanol-ethanol fermentation at batch mode cannot compete with chemically derived butanol because of the low reactor productivity. Continuous fermentation can dramatically enhance productivity and lower capit…
View article: Trans-Esterifiable Bio Lipids Synthesis in Bacterial Isolates Using Limonene Containing Waste
Trans-Esterifiable Bio Lipids Synthesis in Bacterial Isolates Using Limonene Containing Waste Open
Bio-oil is recognized as a sustainable eco-friendly source of energy and a potential candidate to substitute the use of petro-diesel. In the present study, cultivation of a novel oleaginous culture KM9 was evaluated for bio-oil production …
View article: Editorial: Development and Application of Clostridia as Microbial Cell-Factories for Biofuels and Biochemicals Production
Editorial: Development and Application of Clostridia as Microbial Cell-Factories for Biofuels and Biochemicals Production Open
EDITORIAL article Front. Bioeng. Biotechnol., 11 January 2022Sec. Synthetic Biology Volume 9 - 2021 | https://doi.org/10.3389/fbioe.2021.831135
View article: PsrA is a novel regulator contributes to antibiotic synthesis, bacterial virulence, cell motility and extracellular polysaccharides production in <i>Serratia marcescens</i>
PsrA is a novel regulator contributes to antibiotic synthesis, bacterial virulence, cell motility and extracellular polysaccharides production in <i>Serratia marcescens</i> Open
Serratia marcescens is a Gram-negative bacterium of the Enterobacteriaceae family that can produce numbers of biologically active secondary metabolites. However, our understanding of the regulatory mechanisms behind secondary metabolites b…
View article: A Potential Probiotic for Diarrhea: Clostridium tyrobutyricum Protects Against LPS-Induced Epithelial Dysfunction via IL-22 Produced By Th17 Cells in the Ileum
A Potential Probiotic for Diarrhea: Clostridium tyrobutyricum Protects Against LPS-Induced Epithelial Dysfunction via IL-22 Produced By Th17 Cells in the Ileum Open
Probiotics are clinically used for diarrhea and inflammatory bowel diseases in both humans and animals. Previous studies have shown that Clostridium tyrobutyricum (Ct) protects against intestinal dysfunction, while its regulatory function …
View article: Enhanced Prodigiosin Production in <i>Serratia marcescens</i> JNB5-1 by Introduction of a Polynucleotide Fragment into the <i>pigN</i> 3′ Untranslated Region and Disulfide Bonds into <i>O</i> -Methyl Transferase (PigF)
Enhanced Prodigiosin Production in <i>Serratia marcescens</i> JNB5-1 by Introduction of a Polynucleotide Fragment into the <i>pigN</i> 3′ Untranslated Region and Disulfide Bonds into <i>O</i> -Methyl Transferase (PigF) Open
This study highlights a promising strategy to improve mRNA/enzyme stability and to increase production using de novo PNF libraries and the introduction of disulfide bonds into the protein. PNFs could increase the half-life of target gene m…
View article: A Novel Inulin-Mediated Ethanol Precipitation Method for Separating Endo-Inulinase From Inulinases for Inulooligosaccharides Production From Inulin
A Novel Inulin-Mediated Ethanol Precipitation Method for Separating Endo-Inulinase From Inulinases for Inulooligosaccharides Production From Inulin Open
Inulin is a kind of polysaccharide that can be obtained various biomass. Inulooligosaccharides (IOS), a kind of oligosaccharides that can be obtained from inulin by enzymatic hydrolysis using inulinases, have been regarded as the functiona…
View article: Engineering <i>Clostridium cellulovorans</i> for highly selective <i>n</i>‐butanol production from cellulose in consolidated bioprocessing
Engineering <i>Clostridium cellulovorans</i> for highly selective <i>n</i>‐butanol production from cellulose in consolidated bioprocessing Open
Cellulosic n ‐butanol from renewable lignocellulosic biomass has gained increased interest. Previously, we have engineered Clostridium cellulovorans , a cellulolytic acidogen, to overexpress the bifunctional butyraldehyde/butanol dehydroge…
View article: Regulator RcsB Controls Prodigiosin Synthesis and Various Cellular Processes in Serratia marcescens JNB5-1
Regulator RcsB Controls Prodigiosin Synthesis and Various Cellular Processes in Serratia marcescens JNB5-1 Open
RcsB is a two-component response regulator in the Rcs phosphorelay system, and it plays versatile regulatory functions in Enterobacteriaceae . However, information on the function of the RcsB protein in bacteria, especially in S. marcescen…
View article: Structural insight into interaction and conformation mechanisms of Serratia marcescens lysine decarboxylase (SmcadA)
Structural insight into interaction and conformation mechanisms of Serratia marcescens lysine decarboxylase (SmcadA) Open
Inducible lysine decarboxylases (LDCs) are essential in various cellular processes of microorganisms and plants, especially under acid stress, which induces expression of genes encoding LDCs. In this study, a novel Serratia marcesenes LDC …
View article: Improved Prodigiosin Production by Relieving CpxR Temperature-Sensitive Inhibition
Improved Prodigiosin Production by Relieving CpxR Temperature-Sensitive Inhibition Open
Prodigiosin (PG) is a typical secondary metabolite mainly produced by Serratia marcescens. CpxR protein is an OmpR family transcriptional regulator in Gram-negative bacteria. Firstly, it was found that insertion mutation of cpxR<…
View article: An integrated process for butanol production from cellulosic biomass and CO<sub>2</sub> using engineered clostridia in a linear immobilized bioreactor
An integrated process for butanol production from cellulosic biomass and CO<sub>2</sub> using engineered clostridia in a linear immobilized bioreactor Open
Engineered platforms using mixed microbial consortia to consolidate multiple reaction steps and perform disparate conversions simultaneously can substantially enhance the carbon efficiency of biomass conversion processes and lower the biof…
View article: Engineering Clostridia for <em>n</em>-Butanol Production from Lignocellulosic Biomass and CO<sub>2</sub> (Final Report)
Engineering Clostridia for <em>n</em>-Butanol Production from Lignocellulosic Biomass and CO<sub>2</sub> (Final Report) Open
The objective of this project was to engineer novel Clostridium strains to produce n-butanol from low-cost lignocellulosic biomass and gases (CO2 and H2). Butanol is an important industrial solvent and potentially a s…
View article: LysR-Type Transcriptional Regulator MetR Controls Prodigiosin Production, Methionine Biosynthesis, Cell Motility, H <sub>2</sub> O <sub>2</sub> Tolerance, Heat Tolerance, and Exopolysaccharide Synthesis in Serratia marcescens
LysR-Type Transcriptional Regulator MetR Controls Prodigiosin Production, Methionine Biosynthesis, Cell Motility, H <sub>2</sub> O <sub>2</sub> Tolerance, Heat Tolerance, and Exopolysaccharide Synthesis in Serratia marcescens Open
Serratia marcescens , a Gram-negative bacterium, is found in a wide range of ecological niches and can produce several secondary metabolites, including prodigiosin, althiomycin, and serratamolide. Among them, prodigiosin shows diverse func…
View article: Engineered disulfide bonds improve thermostability and activity of L‐isoleucine hydroxylase for efficient 4‐HIL production in <i>Bacillus subtilis</i> 168
Engineered disulfide bonds improve thermostability and activity of L‐isoleucine hydroxylase for efficient 4‐HIL production in <i>Bacillus subtilis</i> 168 Open
4‐Hydroxyisoleucine, a promising drug, has mainly been applied in the clinical treatment of type 2 diabetes in the pharmaceutical industry. l ‐Isoleucine hydroxylase specifically converts l‐ Ile to 4‐hydroxyisoleucine. However, due to its …
View article: Engineering Clostridium for improved solvent production: recent progress and perspective
Engineering Clostridium for improved solvent production: recent progress and perspective Open
View article: Development of a shuttle plasmid without host restriction sites for efficient transformation and heterologous gene expression in Clostridium cellulovorans
Development of a shuttle plasmid without host restriction sites for efficient transformation and heterologous gene expression in Clostridium cellulovorans Open
View article: n-Butanol and ethanol production from cellulose by Clostridium cellulovorans overexpressing heterologous aldehyde/alcohol dehydrogenases
n-Butanol and ethanol production from cellulose by Clostridium cellulovorans overexpressing heterologous aldehyde/alcohol dehydrogenases Open
View article: Metabolic engineering of Clostridium carboxidivorans for enhanced ethanol and butanol production from syngas and glucose
Metabolic engineering of Clostridium carboxidivorans for enhanced ethanol and butanol production from syngas and glucose Open
View article: Biosynthesis of polymalic acid in fermentation: advances and prospects for industrial application
Biosynthesis of polymalic acid in fermentation: advances and prospects for industrial application Open
Some microorganisms naturally produce β-poly(l-malic acid) (PMA), which has excellent water solubility, biodegradability, and biocompatibility properties. PMA has broad prospective applications as novel biopolymeric materials and carriers …
View article: Asp305Gly mutation improved the activity and stability of the styrene monooxygenase for efficient epoxide production in Pseudomonas putida KT2440
Asp305Gly mutation improved the activity and stability of the styrene monooxygenase for efficient epoxide production in Pseudomonas putida KT2440 Open
This study offers an alternative strategy for improved SMO expression and provides an efficient biocatalytic system for epoxide production via engineering the entrance tunnel of the enzyme's active site.
View article: Design of a high‐efficiency synthetic system for <scp>l</scp>‐asparaginase production in <i>Bacillus subtilis</i>
Design of a high‐efficiency synthetic system for <span>l</span>‐asparaginase production in <i>Bacillus subtilis</i> Open
l ‐asparaginase has high application value in medicine and food industry, but the low yield limits its application. In this study, we designed a synthetic system in Bacillus subtilis to produce l ‐asparaginase by improving gene expression …
View article: Deciphering mixotrophic Clostridium formicoaceticum metabolism and energy conservation: Genomic analysis and experimental studies
Deciphering mixotrophic Clostridium formicoaceticum metabolism and energy conservation: Genomic analysis and experimental studies Open
View article: Butyric acid: Applications and recent advances in its bioproduction
Butyric acid: Applications and recent advances in its bioproduction Open