Shangqing Song
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View article: Attenuated crosstalk between urothelium and fibroblasts promotes ureteral stricture development Urothelial-Fibroblast Crosstalk in Stricture
Attenuated crosstalk between urothelium and fibroblasts promotes ureteral stricture development Urothelial-Fibroblast Crosstalk in Stricture Open
Background Ureteral stricture (US), characterized by fibrotic remodeling of the ureteral wall, represents an obstructive urological disorder with incompletely characterized pathophysiological mechanisms. This study integrates single-cell R…
View article: Exploring the prognostic significance and therapeutic potential of SUCLG2 in prostate cancer
Exploring the prognostic significance and therapeutic potential of SUCLG2 in prostate cancer Open
Background Prostate cancer (PCa), a highly heterogeneous cancer with a complex molecular pathogenesis, is a leading cause of cancer-related mortality among men globally. The present study presents a lipid metabolism-based risk model for PC…
View article: Screening of tumor antigens and immunogenic cell death landscapes of prostate adenocarcinoma for exploration of mRNA vaccine
Screening of tumor antigens and immunogenic cell death landscapes of prostate adenocarcinoma for exploration of mRNA vaccine Open
In summary, the research may provide a theoretical foundation for developing mRNA vaccine against PRAD as well as determining appropriate vaccine recipients.
View article: Screening of tumor antigens and immunogenic cell death landscapes of prostate cancer for exploration of mRNA vaccine
Screening of tumor antigens and immunogenic cell death landscapes of prostate cancer for exploration of mRNA vaccine Open
Background Although the mRNA vaccine is effective against many kinds of cancers, its efficacy against prostate adenocarcinoma (PRAD) is still unclear. In this study, effective antigens of mRNA vaccine were excavated from the perspective of…
View article: Long-term outcomes of cryoablation for biopsy-proven T1 stage renal cell carcinoma
Long-term outcomes of cryoablation for biopsy-proven T1 stage renal cell carcinoma Open
Background To summarize our clinical experience of cryoablation in renal cell carcinoma (RCC) of Chinese population and to evaluate the long-term outcomes of laparoendoscopic single-site (LESS) cryoablation (LCA) as well as percutaneous CT…
View article: Long-term outcomes of cryoablation for biopsy-proven T1 stage renal cell carcinoma
Long-term outcomes of cryoablation for biopsy-proven T1 stage renal cell carcinoma Open
Objective To summarize our clinical experience of cryoablation in renal cell carcinoma (RCC) of Chinese population and to evaluate the long-term outcomes of laparoendoscopic single-site (LESS) cryoablation (LCA) as well as percutaneous CT-…
View article: Identification of Metabolism-Related Gene-Based Subgroup in Prostate Cancer
Identification of Metabolism-Related Gene-Based Subgroup in Prostate Cancer Open
Prostate cancer is still the main male health problem in the world. The role of metabolism in the occurrence and development of prostate cancer is becoming more and more obvious, but it is not clear. Here we firstly identified a metabolism…
View article: Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer
Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer Open
Background 5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers. However, the prognostic value of m5C regulatory genes and th…
View article: Long-term outcomes of cryoablation for biopsy-proven T1 stage renal cell carcinoma
Long-term outcomes of cryoablation for biopsy-proven T1 stage renal cell carcinoma Open
Objective To summarize our clinical experience of cryoablation in renal cell carcinoma (RCC) of Chinese population and to evaluate the long-term outcomes of laparoendoscopic single-site (LESS) cryoablation (LCA) as well as percutaneous CT-…
View article: SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1α signaling
SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1α signaling Open
Over the last decade, more than 10 independent SNPs have been discovered to be associated with the risk of renal cell carcinoma among different populations. However, the biological functions of them remain poorly understood. In this study,…
View article: LPCAT1 enhances castration resistant prostate cancer progression via increased mRNA synthesis and PAF production
LPCAT1 enhances castration resistant prostate cancer progression via increased mRNA synthesis and PAF production Open
Our previously study shown that Lysophosphatidylcholine Acyltransferase1 (LPCAT1) is overexpressed in castration resistant prostate cancer (CRPC) relative to primary prostate cancer (PCa), and androgen controls its expression via the Wnt s…
View article: Urinary exosome miR‐30c‐5p as a biomarker of clear cell renal cell carcinoma that inhibits progression by targeting HSPA5
Urinary exosome miR‐30c‐5p as a biomarker of clear cell renal cell carcinoma that inhibits progression by targeting HSPA5 Open
Exosome‐derived miRNAs are regarded as biomarkers for the diagnosis and prognosis of many human cancers. However, its function in clear cell renal cell carcinoma (ccRCC) remains unclear. In this study, differentially expressed miRNAs from …
View article: IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis
IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis Open
IL-22, a member of the IL-10 cytokine family, accelerates tubule regeneration upon acute kidney injury, hence we speculated on a protective role also in chronic kidney disease. We quantified intrarenal IL-22 expression after unilateral ure…
View article: Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury
Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury Open
Notch and interleukin-22 (IL-22) signaling are known to regulate tissue homeostasis and respond to injury in humans and mice, and the induction of endogenous aryl hydrocarbon receptor (Ahr) ligands through Notch links the two pathways in a…
View article: A histology-based four protein array for postoperative outcome prediction in clear cell renal cell carcinoma
A histology-based four protein array for postoperative outcome prediction in clear cell renal cell carcinoma Open
Renal cell carcinoma is the 9th and the 14th most common cancer in men and women worldwide, respectively. Clear cell histology is the most common subtype of renal cell carcinoma, which accounts for about 70-75% of all cases. The pathogenes…