Shangying Chen
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Evaluation of hydrological responses to climate change for a data-scarce mountainous watershed in Taiwan Open
Despite the mountainous watersheds being important for the ecosystem, water resources, and hydropower, little hydrological data has been collected. This data scarcity makes it difficult to evaluate their hydrologic response to climate chan…
View article: Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS
Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS Open
Primary Epstein-Barr virus (EBV)-positive nodal T/NK-cell lymphoma (PTCL-EBV) is a poorly understood disease which shows features resembling extranodal NK/T-cell lymphoma (ENKTL) and is currently not recognized as a distinct entity but cat…
View article: T-Cell Lymphoma Clonality by Copy Number Variation Analysis of T-Cell Receptor Genes
T-Cell Lymphoma Clonality by Copy Number Variation Analysis of T-Cell Receptor Genes Open
T-cell lymphomas arise from a single neoplastic clone and exhibit identical patterns of deletions in T-cell receptor (TCR) genes. Whole genome sequencing (WGS) data represent a treasure trove of information for the development of novel cli…
Clustering Bioactive Molecules in 3D Chemical Space with Unsupervised Deep Learning Open
Unsupervised clustering has broad applications in data stratification, pattern investigation and new discovery beyond existing knowledge. In particular, clustering of bioactive molecules facilitates chemical space mapping, structure-activi…
Drug sales confirm clinical advantage of multi‐target inhibition of drug escapes by anticancer kinase inhibitors Open
The clinical advantage of co‐targeting cancer drug escape has been indicated by the percentage of these co‐targeting drugs among all multi‐target drugs in clinics and clinical trials. This clinical advantage needs to be further interrogate…
Cover Image, Volume 80, Issue 2 Open
The cover image is based on the Research Article Drug sales confirm clinical advantage of multi-target inhibition of drug escapes by anticancer kinase inhibitors by Shangying Chen et al., https://doi.org/10.1002/ddr.21486.
CMAUP: a database of collective molecular activities of useful plants Open
The beneficial effects of functionally useful plants (e.g. medicinal and food plants) arise from the multi-target activities of multiple ingredients of these plants. The knowledge of the collective molecular activities of these plants faci…
NPASS: natural product activity and species source database for natural product research, discovery and tool development Open
There has been renewed interests in the exploration of natural products (NPs) for drug discovery, and continuous investigations of the therapeutic claims and mechanisms of traditional and herbal medicines. In-silico methods have been emplo…
HEROD: a human ethnic and regional specific omics database Open
Motivation Genetic and gene expression variations within and between populations and across geographical regions have substantial effects on the biological phenotypes, diseases, and therapeutic response. The development of precision medici…
A protein network descriptor server and its use in studying protein, disease, metabolic and drug targeted networks Open
The genetic, proteomic, disease and pharmacological studies have generated rich data in protein interaction, disease regulation and drug activities useful for systems-level study of the biological, disease and drug therapeutic processes. T…