Shangyu Liu
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View article: The prognostic value of stress hyperglycemia ratio (SHR) in cardiac metabolic syndrome: dual-cohort evidence and machine learning modeling
The prognostic value of stress hyperglycemia ratio (SHR) in cardiac metabolic syndrome: dual-cohort evidence and machine learning modeling Open
Objective: This study aimed to evaluate the prognostic value of the stress hyperglycemia ratio (SHR) in predicting all-cause and cardiovascular disease (CVD) mortality among patients with cardiometabolic syndrome (CMS), leveraging large-…
View article: Sinomenine hydrochloride alleviates autoimmune myocarditis via suppressing Th1 cell induced-M1 macrophage pyroptosis
Sinomenine hydrochloride alleviates autoimmune myocarditis via suppressing Th1 cell induced-M1 macrophage pyroptosis Open
Th1 cell-induced M1 macrophage pyroptosis is an essential pathogenic mechanism of EAM. Sinomenine hydrochloride suppresses Th1 cell arginine metabolism, potentially making it a practical approach to treating myocarditis.
View article: Single‐Cell <scp>RNA</scp> Sequencing Reveals the Critical Role of <scp>SEC16B</scp> in Lung Metastasis of Osteosarcoma
Single‐Cell <span>RNA</span> Sequencing Reveals the Critical Role of <span>SEC16B</span> in Lung Metastasis of Osteosarcoma Open
Osteosarcoma (OS) is highly malignant and easily prone to lung metastasis. The mechanisms of lung metastasis in OS remain unclear. The single‐cell RNA sequencing (scRNA‐seq) samples in this study included six primary osteosarcoma samples (…
View article: A comprehensive analysis of transcription factors identified TCF3 as a prognostic target for glioma
A comprehensive analysis of transcription factors identified TCF3 as a prognostic target for glioma Open
Transcription factors (TFs) are pivotal in tumor initiation and progression, regulating downstream gene expression and modulating cellular processes. In this study, we conducted a comprehensive analysis of TF gene sets to define the molecu…
View article: Synergetic Effect of Multicomponent Phosphate and Rich Grain‐Boundary in Solid/Electrolyte Interphase Boosts Rapid Ion Transport Toward Fast Aqueous Zinc Metal Batteries
Synergetic Effect of Multicomponent Phosphate and Rich Grain‐Boundary in Solid/Electrolyte Interphase Boosts Rapid Ion Transport Toward Fast Aqueous Zinc Metal Batteries Open
The development of fast‐charging aqueous zinc (Zn) metal batteries is crucial for large‐scale energy storage applications. However, in pursuit of fast‐charging capability under a high current density (>10 mA cm −2 ), the intensified Zn 2+ …
View article: LncRNA SNHG15 promotes angiogenesis and improves cardiac repair after myocardial infarction through MiR-665-mediated KDR expression
LncRNA SNHG15 promotes angiogenesis and improves cardiac repair after myocardial infarction through MiR-665-mediated KDR expression Open
View article: Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight
Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight Open
Diabetic cardiomyopathy is a myocardial structural and functional abnormality directly caused by diabetes and is a principal factor in the development of cardiovascular complications in patients with diabetes. The study aims to investigate…
View article: Enhancing Student Behavior with the Learner-Centered Approach in Sustainable Hospitality Education
Enhancing Student Behavior with the Learner-Centered Approach in Sustainable Hospitality Education Open
This study aims to implement the concept of education for sustainable development by 2030, which can be applied in the context of hospitality education in the Asia–Pacific region. Specifically, this study focuses on achieving Sustainable D…
View article: Periprocedural Inflammatory and Myocardial Injury Biomarker Comparison in AF PFA Versus RFA.
Periprocedural Inflammatory and Myocardial Injury Biomarker Comparison in AF PFA Versus RFA. Open
View article: Single-cell and spatial transcriptomics reveals the key role of MCAM+ tip-like endothelial cells in osteosarcoma metastasis
Single-cell and spatial transcriptomics reveals the key role of MCAM+ tip-like endothelial cells in osteosarcoma metastasis Open
View article: Arthroscopic-assisted uni-portal non-coaxial endoscopic surgery treatment of fibrous dysplasia of the femur: a minimally invasive alternative to open surgery
Arthroscopic-assisted uni-portal non-coaxial endoscopic surgery treatment of fibrous dysplasia of the femur: a minimally invasive alternative to open surgery Open
This case report demonstrates that AUNES-assisted tumor lesion curettage and bone grafting fusion surgery for FD is safe and feasible. It offers several advantages, including minimal invasiveness, a wide surgical field, thorough lesion cur…
View article: Constructing a Predictive Model for PD-1 Blockade Therapy in Pan-Cancer Based on Machine Learning
Constructing a Predictive Model for PD-1 Blockade Therapy in Pan-Cancer Based on Machine Learning Open
Programmed cell death protein-1 (PD-1) blockade therapy have shown significant efficacy in cancer immunotherapy. However, low response rates and individual variability remain challenges. Currently, a universal biomarker to assess immunothe…
View article: Deciphering single-cell landscape unravels cell-type-specific functional roles of RNA m<sup>6</sup>A modification in atherosclerosis
Deciphering single-cell landscape unravels cell-type-specific functional roles of RNA m<sup>6</sup>A modification in atherosclerosis Open
Background: Atherosclerosis is a chronic inflammatory disease that is the major cause of mortality worldwide. Although several studies have assessed the function of m6A (N6-methyladenosine) modification in athe…
View article: KCNE3 Facilitates M1 Macrophage Polarization by Suppressing the Wnt/β‐Catenin Pathway, Inhibiting Glioma Proliferation, Migration, and Invasion
KCNE3 Facilitates M1 Macrophage Polarization by Suppressing the Wnt/β‐Catenin Pathway, Inhibiting Glioma Proliferation, Migration, and Invasion Open
The glioma microenvironment is critical for tumor growth, where reprogramming M2‐polarized tumor‐associated macrophages/microglia (TAMs) to an antitumor M1 phenotype represents a promising therapeutic strategy. While the potassium channel …
View article: Association between the screen time spent watching short videos at bedtime and essential hypertension in young and middle-aged people: a cross-sectional study
Association between the screen time spent watching short videos at bedtime and essential hypertension in young and middle-aged people: a cross-sectional study Open
The screen time spent watching short videos at bedtime was significantly associated with essential hypertension in young and middle-aged people, and the nomogram was a good predictor of the risk of essential hypertension among young and mi…
View article: Correction: Prognostic value of high-sensitivity C-reactive protein in patients undergoing percutaneous coronary intervention with different glycemic metabolism status
Correction: Prognostic value of high-sensitivity C-reactive protein in patients undergoing percutaneous coronary intervention with different glycemic metabolism status Open
View article: T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing
T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing Open
The siIRF1 nanotherapeutic approach shows potential for attenuating myocardial inflammation and mitigating myocarditis progression. Our study highlights the promise of this customized biomimetic nano-delivery system for treating inflammato…
View article: Catheter Ablation for Ventricular Tachycardia in Patients With Biopsy-Proven Myocarditis
Catheter Ablation for Ventricular Tachycardia in Patients With Biopsy-Proven Myocarditis Open
View article: Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants Compared with Vitamin K Antagonists in Patients with Atrial Fibrillation and Type 2 Valvular Heart Disease: A Systematic Review and Meta-Analysis
Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants Compared with Vitamin K Antagonists in Patients with Atrial Fibrillation and Type 2 Valvular Heart Disease: A Systematic Review and Meta-Analysis Open
NOACs demonstrate efficacy and safety in patients with AF and type 2 VHD and reduce the risk of stroke/SE and ICH when compared with those with VKAs.
View article: Association of M2 macrophages with EMT in glioma identified through combination of multi-omics and machine learning
Association of M2 macrophages with EMT in glioma identified through combination of multi-omics and machine learning Open
View article: Single-cell and spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma
Single-cell and spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma Open
View article: T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing
T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing Open
Utilizing small interfering RNA (siRNA) for gene silencing presents a viable strategy for treating human diseases, including cardiovascular disorders. However, the strategic targeting and delivery of siRNA therapeutics to desired tissues o…
View article: Catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy and biventricular involvement
Catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy and biventricular involvement Open
Aims Catheter ablation of ventricular tachycardia (VT) improves VT-free survival in ‘classic’ arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to investigate electrophysiological features and ablation outcomes in pat…
View article: Bisphenol A: Unveiling Its Role in Glioma Progression and Tumor Growth
Bisphenol A: Unveiling Its Role in Glioma Progression and Tumor Growth Open
Gliomas represent the most common and lethal category of primary brain tumors. Bisphenol A (BPA), a widely recognized endocrine disruptor, has been implicated in the progression of cancer. Despite its established links to various cancers, …
View article: Electrophysiological Characteristics and Ablation Outcomes in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
Electrophysiological Characteristics and Ablation Outcomes in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia Open
Background Catheter ablation of premature ventricular contractions (PVCs) that trigger polymorphic ventricular tachycardia (PVT) or ventricular fibrillation has been reported as a novel therapy to reduce the syncope events in patients with…
View article: Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway
Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway Open
Our findings indicated the crucial role of macrophage pyroptosis in the pathogenesis of EAM. Lup ameliorated EAM by inhibiting the M1 polarization and pyroptosis of macrophages through the PPARα/LACC1/NF-κB signaling pathway. Thus, our res…
View article: Prognostic value of high-sensitivity C-reactive protein in patients undergoing percutaneous coronary intervention with different glycemic metabolism status
Prognostic value of high-sensitivity C-reactive protein in patients undergoing percutaneous coronary intervention with different glycemic metabolism status Open
View article: Association of survivin positive circulating tumor cell levels with immune escape and prognosis of osteosarcoma
Association of survivin positive circulating tumor cell levels with immune escape and prognosis of osteosarcoma Open
View article: Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq Open
Osteosarcoma (OS) is a primary bone tumor with high malignancy and the mechanism of hematogenous metastasis in OS is still not clear. The plasma exosomes derived from osteosarcoma play a key role in the process of tumor metastasis. Here, w…
View article: Interaction gene set between osteoclasts and regulatory <scp>CD4<sup>+</sup></scp> T cells can accurately predict the prognosis of patients with osteosarcoma
Interaction gene set between osteoclasts and regulatory <span>CD4<sup>+</sup></span> T cells can accurately predict the prognosis of patients with osteosarcoma Open
Osteoclasts (OCs) and regulatory CD4 + T cells (CD4 + Tregs) are important components in the tumor microenvironment (TME) of osteosarcoma. In this study, we collected six osteosarcoma samples from our previous study (GSE162454). We also in…