Explanipedia

A novel serum glucocorticoid regulated kinase 1 inhibitor improves cardiac structure and function in heart failure Open

Eric Campeau, Sabindra Pradhananga, Dinesh Srinivasan, Marc Vidal, Delphine Labit , et al. · 2025

Despite the advent of transformative guideline-directed therapy, heart failure (HF) remains a leading cause of hospitalization and mortality worldwide, underscoring an urgent need for novel therapies. Clinical benefits of contemporary inte…

From Laboratory to Industry: Awareness of the translational potential of Extracellular Vesicles. Results of first survey performed by the ISEV Translation, Regulation and Advocacy Committee (ISEV-TRA) Open

Uxía Gurriarán‐Rodríguez, Benedetta Bussolati, Mario Gimona, Konstantin Glebov, Yu Fujita , et al. · 2025

Extracellular vesicles (EVs) are critical mediators of cellular communication, with significant potential for disease diagnosis, therapeutics, and other industrial applications. However, translating EV-based innovations into real-world pro…

State-dependent release of extracellular particles with distinct α2,6-sialylation patterns and small RNA cargo related to neuroinflammation Open

Marta García-Contreras, Carinna Lima, Eric Alsop, Balazs Kaszala, Bessie Meechoovet , et al. · 2025

Neuroinflammation is a significant contributor to neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and related dementias; yet peripheral biomarkers for neuroinflammation remain an unmet medical need. Microgli…

Exploring Size Exclusion Chromatography Columns 20 and 35 nm Pore Size Effect for Isolation of Extracellular Vesicles Open

Balazs Kaszala, Vincenzo Scarsella, Kriti Bomb, John F. Fay, Barbara L. Smith , et al. · 2025

Extracellular vesicles (EVs) have shown great promise as minimally invasive biomarkers for a variety of diseases. However, challenges persist regarding EV isolation, particularly in their co-isolation with impurities such as soluble protei…

AstroGreen transgenic mouse illuminates the trafficking of astrocyte-derived extracellular vesicles Open

Lisa Nieland, Edwina Abou Haidar, David Rufino‐Ramos, Shilpa Prabhakar, Youssef Samaha , et al. · 2025

Astrocytes interact with neighboring cells by releasing extracellular vesicles (EVs). Tools to study astrocyte EV-mediated communication with other brain cells in vivo are essential. In this study, we crossed the Exomap1 transgenic mouse e…

A role of extracellular vesicle-mediated inter-organ communication in obesity-related arrhythmia Open

Worawan B. Limpitikul, Marta García-Contreras, Michael J. Betti, Phillip R. Spangler, Marta García-Contreras , et al. · 2025

Obesity contributes to the risk of cardiac arrhythmias, but the exact mechanism remains unclear. Here, we show visceral adipose tissue-derived extracellular vesicles (VAT EVs) from individuals with obesity prolong action potential duration…

Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling Open

Priyanka Gokulnath, Ane Salvador, Caleb Graham, Si‐ping Han, Guoping Li , et al. · 2025

Heart failure (HF) remains a significant healthcare burden, with an unmet need for novel therapies to target the preceding pathological hypertrophy in HF patients. Here we report the development of novel conditional-siRNA (Cond-siRN…

43 NATURAL LANGUAGE PROCESSING MODEL-BASED SOLUTION FOR LABELING BRAIN METASTASIS IN RADIOLOGY REPORTS Open

Tianyu Liu, Yan Han, Hui Zuo, Eugene Batuyong, Hongwei Lin , et al. · 2025

Brain Cancer Canada Travel Award Recipient Brain metastases (BM) far exceed primary CNS tumours and constitute the majority workload for neuro-oncology care providers. Canadian Cancer Registry captures ~2800 BM identified at the primary ca…

Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure Open

Brian R. Lindman, Andrew Perry, Michelle L Lance, Kaushik Amancherla, Namju Kim , et al. · 2025

The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity Open

Emeli Chatterjee, Michael J. Betti, Quanhu Sheng, Eric R. Gamazon, Margo P. Emont , et al. · 2025

Machine learning-assisted image analysis techniques for glaucoma detection Open

Vaibhav Yadav, Barnali Dey, Udayan Baruah, Saumya Das, Om Prakash · 2025

Glaucoma is an eye disease that damages the optic nerve which is necessary for clear vision. This injury is frequently caused by extremely high pressure inside the eye. Any damage to the optic nerve, which is responsible for transmitting v…

Emerging trends in dengue fever in Bangladesh: Demographic shifts, increased female prevalence and hepatic involvement Open

Sajid Bashir, Hafizul Isam, Sohel Rana, Saumya Das, Faisal Reza , et al. · 2025

Background: Dengue fever remains a significant public health challenge in Bangladesh, with evolving epidemiological trends and clinical manifestations. Recent shifts in the demographic profile, including an increase in older adults and a n…

Therapeutic Evaluation of Camel Milk-Derived Lactoferrin for in vivo Anti-Arthritic Efficacy Open

Anchit Dogra, Avijit Mazumder, Saumya Das, Pratibha Pandey, MVNL Chaitanya · 2025

Small RNAs as therapeutic agents: From catalytic motifs to regulatory pathways Open

John J. Rossi, Saumya Das · 2025

RNA molecules have long been recognized for their central role in protein synthesis, primarily as messengers (mRNAs), ribosomal components, and adaptors (transfer RNAs). Over the past few decades, however, the discovery of small RNAs with …

Preparation, In Vivo and Molecular Docking Study of Nano‐Emulsion Obtained From the Isolated Phytoconstituents of <i>Symplocos racemosa</i> for Mitigating Depression Open

Archna Singh, Avijit Mazumder, Saumya Das, Anmol Kanda · 2025

Depression is a prevalent, chronic, and debilitating disorder characterized by high treatment resistance. Symplocos racemosa , containing phenols and triterpenoids, acts as an antidepressant by elevating brain monoamine levels. This study …

Molecular architecture of human atherosclerosis revealed through integrative human genetics Open

Bassim El‐Sabawi, Michael J. Betti, P. Charles Lin, Xiaoning Huang, Namju Kim , et al. · 2025

Current genetic discovery methods are largely restricted to profiling circulating molecules or genetic architecture, limited in use of tissue-based molecular genetics to identify pathogenic and therapeutic targets. Here, we leverage a mult…

Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome Open

Worawan B. Limpitikul, Michael G. Silverman, Nedyalka Valkov, Jeong‐Gun Park, Ashish Yeri , et al. · 2025

Isolation and Characterization of Extracellular Vesicles and Non-Vesicular Extracellular Particles from Mouse Tissues Open

Marta García-Contreras, Worawan B. Limpitikul, Saumya Das · 2025

Extracellular vesicles (EVs) and non-vesicular extracellular particles (NVEPs) have been recently discovered as part of the diverse components of the secretome. EVs and NVEPs have been shown to differ not only in size and morphology but al…

Pulsed-field ablation in a patient with ventricular arrhythmia storm receiving mechanical circulatory support Open

Alan Hanley, Saumya Das, Tri Q. Nguyen, Ioannis Mastoris, Eriberto Michel , et al. · 2025

Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling Open

Priyanka Gokulnath, Ane Salvador, Caleb Graham, Si‐ping Han, Guoping Li , et al. · 2025

Heart Failure (HF) remains a global epidemic and a significant healthcare burden, with an unmet need for novel therapies to target the preceding pathological hypertrophy in vulnerable patients. Here we report the development of novel condi…

Mapping of Extracellular RNA from Human Biofluids Reveals >17 Million Genomic Loci Covering >18% of the Human Genome that Express Extracellular RNA Open

Sreyya Darsshini Sudharsan Raamasamy, Robert Fullem, Federico Vannuccini, David Chen, Andrew R. Jackson , et al. · 2025

A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research Open

Sun Young Lee, Mikael Klingeborn, Jeff W. M. Bulte, Daniel T. Chiu, Michael Chopp , et al. · 2024

With an evolving understanding and new discoveries in extracellular vesicle (EV) biology and their implications in health and disease, the significant diagnostic and therapeutic potential of EVs for vision research has gained recognition. …

A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver Open

Andrew Perry, Niran Hadad, Emeli Chatterjee, Maria Jiménez Ramos, Eric Farber‐Eger , et al. · 2024

A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver Open

Andrew Perry, Niran Hadad, Emeli Chatterjee, Maria Jiménez Ramos, Eric Farber‐Eger , et al. · 2024

The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity Open

Emeli Chatterjee, Michael J. Betti, Quanhu Sheng, Eric R. Gamazon, Margo P. Emont , et al. · 2024

We characterized circulating extracellular vesicles (EVs) in obese and lean humans, identifying transcriptional cargo differentially expressed in obesity. Since circulating EVs may have broad origin, we compared this obesity EV transcripto…

EV-idence uncovered: kidney-on-chip study links circulating EVs of cardiorenal syndrome to renal pathology Open

Hawa S. Ndiaye, Sandeep Rajput, John Sauld, Gautam Mahajan, Saumya Das , et al. · 2024

The intertwined nature of cardiac and renal failure, where dysfunction in one organ predicts a poor outcome in the other, has long driven the interest in uncovering the exact molecular links between the two. Elucidating the mechanisms driv…

Clinical Utility of Assessing CDKN2A Status in Recurrent Astrocytomas Open

Hemlata Jangir, Saroj Kumar Yadav, M. B. Hayagrivas, Jyotsna Singh, Sumanto Das , et al. · 2024

Background: IDH-mutant astrocytomas exhibit a more indolent natural history and better prognosis compared to their IDH-wild type counterparts. The 2021 WHO classification integrated CDKN2A/Bhomozygous deletion as a crucial criterion for gr…

Circulating Extracellular Mitochondria in Cardiometabolic Disease: Harnessing the Potential for Diagnosis, Prognosis, and Treatment Open

Michail Spanos, Priyanka Gokulnath, Olivia Rosina Whittaker, Christopher Azzam, Emeli Chatterjee , et al. · 2024

Mitochondria are crucial for cellular functioning, serving as both an intracellular energy source and a signaling organelle. Recent evidence also highlights their existence outside of cells, where they participate in cell-to-cell communica…

Multiparametric profiling of HER2-enriched extracellular vesicles in breast cancer using Single Extracellular VEsicle Nanoscopy Open

Nan Jiang, András Saftics, Eugenia Romano, Ima Ghaeli, Cristal Resto , et al. · 2024

SEVEN revealed unique characteristics of HER2-enriched EVs in cultured cells and complex biological fluid. In combination with current clinical approaches, this method is well poised to support precise therapeutic decisions.

Cardiomyocyte-derived circulating extracellular vesicles allow a non-invasive liquid biopsy of myocardium in health and disease Open

Michail Spanos, Priyanka Gokulnath, Guoping Li, Elizabeth Hutchins, Bessie Meechoovet , et al. · 2024

SUMMARY The ability to track disease without tissue biopsy in patients is a major goal in biology and medicine. Here, we identify and characterize cardiomyocyte-derived extracellular vesicles in circulation (EVs; “cardiovesicles”) through …

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