Shannon C. Brady
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View article: Single-cell Senseless protein analysis reveals metastable states during the transition to a sensory organ fate
Single-cell Senseless protein analysis reveals metastable states during the transition to a sensory organ fate Open
Cell fate decisions can be envisioned as bifurcating dynamical systems, and the decision that Drosophila cells make during sensory organ differentiation has been described as such. We extended these studies by focusing on the Senseless pro…
View article: Single-cell Senseless protein analysis reveals metastable states during the transition to a sensory organ fate
Single-cell Senseless protein analysis reveals metastable states during the transition to a sensory organ fate Open
Cell fate decisions can be envisioned as bifurcating dynamical systems, and the decision that Drosophila cells make during sensory organ differentiation has been described as such. We extended these studies by focusing on the Senseless pro…
View article: Two novel loci underlie natural differences in Caenorhabditis elegans abamectin responses
Two novel loci underlie natural differences in Caenorhabditis elegans abamectin responses Open
Parasitic nematodes cause a massive worldwide burden on human health along with a loss of livestock and agriculture productivity. Anthelmintics have been widely successful in treating parasitic nematodes. However, resistance is increasing,…
View article: Two novel loci underlie natural differences in<i>Caenorhabditis elegans</i>macrocyclic lactone responses
Two novel loci underlie natural differences in<i>Caenorhabditis elegans</i>macrocyclic lactone responses Open
Parasitic nematodes cause a massive worldwide burden on human health along with a loss of livestock and agriculture productivity. Anthelmintics have been widely successful in treating parasitic nematodes. However, resistance is increasing,…
View article: A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans
A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans Open
Over long evolutionary timescales, major changes to the copy number, function, and genomic organization of genes occur, however, our understanding of the individual mutational events responsible for these changes is lacking. In this report…
View article: Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations
Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations Open
Hawaiian isolates of the nematode species Caenorhabditis elegans have long been known to harbor genetic diversity greater than the rest of the worldwide population, but this observation was supported by only a small number of wild strains.…
View article: Deep sampling of Hawaiian<i>Caenorhabditis elegans</i>reveals high genetic diversity and admixture with global populations
Deep sampling of Hawaiian<i>Caenorhabditis elegans</i>reveals high genetic diversity and admixture with global populations Open
Recent efforts to understand the natural niche of the keystone model organism Caenorhabditis elegans have suggested that this species is cosmopolitan and associated with rotting vegetation and fruits. However, most of the strains isolated …
View article: A Novel Gene Underlies Bleomycin-Response Variation in<i>Caenorhabditis elegans</i>
A Novel Gene Underlies Bleomycin-Response Variation in<i>Caenorhabditis elegans</i> Open
Bleomycin is a powerful chemotherapeutic drug used to treat a variety of cancers. However, individual patients vary in their responses to bleomycin. The identification of genetic differences that underlie this response variation could impr…
View article: Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism
Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism Open
We find that variation in the dbt-1 gene underlies natural differences in Caenorhabditis elegans responses to the toxin arsenic. This gene encodes the E2 subunit of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, a core compo…
View article: A beneficial genomic rearrangement creates multiple versions of calcipressin in<i>C. elegans</i>
A beneficial genomic rearrangement creates multiple versions of calcipressin in<i>C. elegans</i> Open
Gene duplication is a major source of genetic novelty and evolutionary adaptation, providing a molecular substrate that can generate biological complexity and diversity (Ohno 1967, Taylor and Raes 2004). Despite an abundance of genomic evi…
View article: A nematode-specific gene underlies bleomycin-response variation in<i>Caenorhabditis elegans</i>
A nematode-specific gene underlies bleomycin-response variation in<i>Caenorhabditis elegans</i> Open
Bleomycin is a powerful chemotherapeutic drug used to treat a variety of cancers. However, individual patients vary in their responses to bleomycin. The identification of genetic differences that underlie this response variation could impr…
View article: Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses
Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses Open
Phenotypic complexity is caused by the contributions of environmental factors and multiple genetic loci, interacting or acting independently. Studies of yeast and Arabidopsis often find that the majority of natural variation across phenoty…
View article: Discovery of genomic intervals that underlie nematode responses to benzimidazoles
Discovery of genomic intervals that underlie nematode responses to benzimidazoles Open
Parasitic nematodes impose a debilitating health and economic burden across much of the world. Nematode resistance to anthelmintic drugs threatens parasite control efforts in both human and veterinary medicine. Despite this threat, the gen…
View article: The genetic basis of natural variation in a phoretic behavior
The genetic basis of natural variation in a phoretic behavior Open
Phoresy is a widespread form of commensalism that facilitates dispersal of one species through an association with a more mobile second species. Dauer larvae of the nematode Caenorhabditis elegans exhibit a phoretic behavior called nictati…
View article: Discovery of unique loci that underlie nematode responses to benzimidazoles
Discovery of unique loci that underlie nematode responses to benzimidazoles Open
Parasitic nematodes impose a debilitating health and economic burden across much of the world. Nematode resistance to anthelmintic drugs threatens parasite control efforts in both human and veterinary medicine. Despite this threat, the gen…
View article: Correlations of Genotype with Climate Parameters Suggest <i>Caenorhabditis elegans</i> Niche Adaptations
Correlations of Genotype with Climate Parameters Suggest <i>Caenorhabditis elegans</i> Niche Adaptations Open
Species inhabit a variety of environmental niches, and the adaptation to a particular niche is often controlled by genetic factors, including gene-by-environment interactions. The genes that vary in order to regulate the ability to coloniz…
View article: Correlations of genotype with climate parameters suggest<i>Caenorhabditis elegans</i>niche preferences
Correlations of genotype with climate parameters suggest<i>Caenorhabditis elegans</i>niche preferences Open
Species inhabit a variety of environmental niches, and the adaptation to a particular niche is often controlled by genetic factors, including gene-by-environment interactions. The genes that vary in order to regulate the ability to coloniz…
View article: Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans
Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans Open
Evolutionary life history theory seeks to explain how reproductive and survival traits are shaped by selection through allocations of an individual's resources to competing life functions. Although life-history traits evolve rapidly, littl…