Shannon N. Bennett
YOU?
Author Swipe
View article: Persistent open chromatin state in early-life stress-activated cells of the VTA
Persistent open chromatin state in early-life stress-activated cells of the VTA Open
Early-life stress sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the ventral tegmental area (VTA), a mesolimbic brain region implicated in stress response and mental health, early…
View article: Enhancing capacities in genomic surveillance capabilities for SARS-CoV-2 and dengue virus: A South-South collaborative partnership
Enhancing capacities in genomic surveillance capabilities for SARS-CoV-2 and dengue virus: A South-South collaborative partnership Open
Latin American countries have faced limited access to new scientific technologies for many years due to restricted budgets for research programs, which has hindered local scientific development. These research disparities became especially…
View article: Tracking the genetic diversity of SARS-CoV-2 variants in Nicaragua throughout the COVID-19 pandemic
Tracking the genetic diversity of SARS-CoV-2 variants in Nicaragua throughout the COVID-19 pandemic Open
View article: Geographic origin and evolution of dengue virus serotypes 1 and 3 circulating in Africa
Geographic origin and evolution of dengue virus serotypes 1 and 3 circulating in Africa Open
Despite the increasing burden of dengue in Kenya and Africa, the introduction and expansion of the virus in the region remain poorly understood. The objective of this study is to examine the genetic diversity and evolutionary histories of …
View article: Molecular epidemiology and evolutionary characteristics of dengue virus 2 in East Africa
Molecular epidemiology and evolutionary characteristics of dengue virus 2 in East Africa Open
View article: Tracking the genetic diversity of SARS-CoV-2 variants in Nicaragua throughout the COVID-19 Pandemic
Tracking the genetic diversity of SARS-CoV-2 variants in Nicaragua throughout the COVID-19 Pandemic Open
The global circulation of SARS-CoV-2 has been extensively documented, yet the dynamics within Central America, particularly Nicaragua, remain underexplored. This study characterizes the genomic diversity of SARS-CoV-2 in Nicaragua from Mar…
View article: Introduction of New Dengue Virus Lineages after COVID-19 Pandemic, Nicaragua, 2022
Introduction of New Dengue Virus Lineages after COVID-19 Pandemic, Nicaragua, 2022 Open
Major dengue epidemics throughout Nicaragua's history have been dominated by 1 of 4 dengue virus serotypes (DENV-1-4). To examine serotypes during the dengue epidemic in Nicaragua in 2022, we performed real-time genomic surveillance in-cou…
View article: Simultaneous co-circulation of two genotypes of dengue virus serotype 3 causing a large outbreak in Sri Lanka in year 2023
Simultaneous co-circulation of two genotypes of dengue virus serotype 3 causing a large outbreak in Sri Lanka in year 2023 Open
As many other countries, Sri Lanka experienced a marked rise in the number of dengue cases in 2023, with an unusual pattern of disease epidemiology. This rise coincided with the emergence of dengue virus (DENV) serotype 3 in Sri Lanka as t…
View article: Data-driven analysis identifies female-specific social modulation deficit after chronic social defeat stress
Data-driven analysis identifies female-specific social modulation deficit after chronic social defeat stress Open
Background Chronic social defeat stress is a widely used depression model in male mice. Several proposed adaptations extend this model to females with variable, often marginal effects. We examine the if widely used male-defined metrics of …
View article: Altered postnatal chromatin development in the nucleus accumbens primes lifelong stress sensitivity
Altered postnatal chromatin development in the nucleus accumbens primes lifelong stress sensitivity Open
Early-life stress (ELS) sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the nucleus accumbens (NAc) — a key limbic and reward-associated brain region — ELS sensitizes both cellular…
View article: Early-life stress alters chromatin modifications in VTA to prime stress sensitivity
Early-life stress alters chromatin modifications in VTA to prime stress sensitivity Open
Early-life stress increases sensitivity to subsequent stress, which has been observed at behavioral, neural activity, and gene expression levels. However, the molecular mechanisms underlying such long-lasting sensitivity are poorly underst…
View article: Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior
Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior Open
Proper thyroid function is essential to the developing brain, including dopamine neuron differentiation, growth, and maintenance. Stress across the lifespan impacts thyroid hormone signaling and anxiety disorders and depression have been a…
View article: Transcriptional signatures of early-life stress and antidepressant treatment efficacy
Transcriptional signatures of early-life stress and antidepressant treatment efficacy Open
Individuals with a history of early-life stress (ELS) tend to have an altered course of depression and lower treatment response rates. Research suggests that ELS alters brain development, but the molecular changes in the brain following EL…
View article: Phylodynamics of dengue virus 2 in Nicaragua leading up to the 2019 epidemic reveals a role for lineage turnover
Phylodynamics of dengue virus 2 in Nicaragua leading up to the 2019 epidemic reveals a role for lineage turnover Open
View article: Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior
Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior Open
Proper thyroid function is essential to the developing brain, including dopamine neuron differentiation, growth, and maintenance. Stress across the lifespan impacts thyroid hormone signaling and anxiety disorders and depression have been a…
View article: Reactivation of Early-Life Stress-Sensitive Neuronal Ensembles Contributes to Lifelong Stress Hypersensitivity
Reactivation of Early-Life Stress-Sensitive Neuronal Ensembles Contributes to Lifelong Stress Hypersensitivity Open
Early-life stress (ELS) is one of the strongest lifetime risk factors for depression, anxiety, suicide, and other psychiatric disorders, particularly after facing additional stressful events later in life. Human and animal studies demonstr…
View article: Phylogenetic Analysis of Transmission Dynamics of Dengue in Large and Small Population Centers, Northern Ecuador
Phylogenetic Analysis of Transmission Dynamics of Dengue in Large and Small Population Centers, Northern Ecuador Open
Although dengue is typically considered an urban disease, rural communities are also at high risk. To clarify dynamics of dengue virus (DENV) transmission in settings with characteristics generally considered rural (e.g., lower population …
View article: Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivity
Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivity Open
Early-life stress (ELS) is one of the strongest lifetime risk factors for depression, anxiety, suicide, and other psychiatric disorders, particularly after facing additional stressful events later in life. Human and animal studies demonstr…
View article: Metagenomic shotgun sequencing reveals host species as an important driver of virome composition in mosquitoes
Metagenomic shotgun sequencing reveals host species as an important driver of virome composition in mosquitoes Open
High-throughput nucleic acid sequencing has greatly accelerated the discovery of viruses in the environment. Mosquitoes, because of their public health importance, are among those organisms whose viromes are being intensively characterized…
View article: Human–Mosquito Contact: A Missing Link in Our Understanding of Mosquito-Borne Disease Transmission Dynamics
Human–Mosquito Contact: A Missing Link in Our Understanding of Mosquito-Borne Disease Transmission Dynamics Open
Despite the critical role that contact between hosts and vectors, through vector bites, plays in driving vector-borne disease (VBD) transmission, transmission risk is primarily studied through the lens of vector density and overlooks host–…
View article: Evolution and epidemiologic dynamics of dengue virus in Nicaragua during the emergence of chikungunya and Zika viruses
Evolution and epidemiologic dynamics of dengue virus in Nicaragua during the emergence of chikungunya and Zika viruses Open
View article: High Dengue Burden and Circulation of 4 Virus Serotypes among Children with Undifferentiated Fever, Kenya, 2014–2017
High Dengue Burden and Circulation of 4 Virus Serotypes among Children with Undifferentiated Fever, Kenya, 2014–2017 Open
Little is known about the extent and serotypes of dengue viruses circulating in Africa. We evaluated the presence of dengue viremia during 4 years of surveillance (2014-2017) among children with febrile illness in Kenya. Acutely ill febril…
View article: Patterns, Drivers, and Challenges of Vector-Borne Disease Emergence
Patterns, Drivers, and Challenges of Vector-Borne Disease Emergence Open
Vector-borne diseases are emerging at an increasing rate and comprise a disproportionate share of all emerging infectious diseases. Yet, the key ecological and evolutionary dimensions of vector-borne disease that facilitate their emergence…
View article: Hyperendemic dengue transmission and identification of a locally evolved DENV-3 lineage, Papua New Guinea 2007-2010
Hyperendemic dengue transmission and identification of a locally evolved DENV-3 lineage, Papua New Guinea 2007-2010 Open
We show that dengue is hyperendemic in PNG and identify an endemic, locally evolved lineage of DENV-3 that was associated with an outbreak of severe dengue in Pacific countries in subsequent years, although severe disease was not identifie…
View article: Mosquito vector‐associated microbiota: Metabarcoding bacteria and eukaryotic symbionts across habitat types in Thailand endemic for dengue and other arthropod‐borne diseases
Mosquito vector‐associated microbiota: Metabarcoding bacteria and eukaryotic symbionts across habitat types in Thailand endemic for dengue and other arthropod‐borne diseases Open
Vector‐borne diseases are a major health burden, yet factors affecting their spread are only partially understood. For example, microbial symbionts can impact mosquito reproduction, survival, and vectorial capacity, and hence affect diseas…
View article: Understanding Past Population Dynamics: Bayesian Coalescent-Based Modeling with Covariates
Understanding Past Population Dynamics: Bayesian Coalescent-Based Modeling with Covariates Open
Effective population size characterizes the genetic variability in a population and is a parameter of paramount importance in population genetics and evolutionary biology. Kingman's coalescent process enables inference of past population d…
View article: Understanding Past Population Dynamics: Bayesian Coalescent-Based Modeling with Covariates
Understanding Past Population Dynamics: Bayesian Coalescent-Based Modeling with Covariates Open
Effective population size characterizes the genetic variability in a population and is a parameter of paramount importance in population genetics. Kingman's coalescent process enables inference of past population dynamics directly from mol…
View article: Understanding Past Population Dynamics: Bayesian Coalescent-Based\n Modeling with Covariates
Understanding Past Population Dynamics: Bayesian Coalescent-Based\n Modeling with Covariates Open
Effective population size characterizes the genetic variability in a\npopulation and is a parameter of paramount importance in population genetics.\nKingman's coalescent process enables inference of past population dynamics\ndirectly from …
View article: Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence
Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence Open
View article: RNA shotgun metagenomic sequencing of northern California (USA) mosquitoes uncovers viruses, bacteria, and fungi
RNA shotgun metagenomic sequencing of northern California (USA) mosquitoes uncovers viruses, bacteria, and fungi Open
Mosquitoes, most often recognized for the microbial agents of disease they may carry, harbor diverse microbial communities that include viruses, bacteria, and fungi, collectively called the microbiota. The composition of the microbiota can…