Shanqiang Qu
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Author Swipe
View article: Contemporary Precision Stratification and Prognostic Features of Primary Gliomas in a Southern Chinese Population
Contemporary Precision Stratification and Prognostic Features of Primary Gliomas in a Southern Chinese Population Open
View article: Transcription factor SP1-Mediated Upregulation of B-Myb Promotes Glioma Aggression Through Transcriptomic Mechanism
Transcription factor SP1-Mediated Upregulation of B-Myb Promotes Glioma Aggression Through Transcriptomic Mechanism Open
Background Given the limited therapeutic options for gliomas, identifying molecules with therapeutic potential remains critical. This study aimed to investigate the functional significance and regulatory mechanisms of B-Myb in glioma progr…
View article: The <scp>HBP</scp> Pathway Inhibitor <scp>FR054</scp> Enhances Temozolomide Sensitivity in Glioblastoma Cells by Promoting Ferroptosis and Inhibiting O‐<scp>GlcNAcylation</scp>
The <span>HBP</span> Pathway Inhibitor <span>FR054</span> Enhances Temozolomide Sensitivity in Glioblastoma Cells by Promoting Ferroptosis and Inhibiting O‐<span>GlcNAcylation</span> Open
Background The clinical efficacy of temozolomide (TMZ) in glioblastoma (GBM) patients is often limited by the development of resistance. To date, no clinically validated therapeutic strategies exist to restore sensitivity to TMZ treatment.…
View article: Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment
Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment Open
Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer initiation, progression, and recurren…
View article: Anlotinib may have a therapeutic effect on papillary craniopharyngiomas without the BRAFv600e mutation
Anlotinib may have a therapeutic effect on papillary craniopharyngiomas without the BRAFv600e mutation Open
BRAFv600e- PCPs are characterized by calcification and do not respond to the BRAF inhibitor vemurafenib, and for which the angiogenesis inhibitor anlotinib may have a significant therapeutic effect.
View article: Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities
Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities Open
Cellular senescence is characterized by a sustained and irreversible cessation of cell proliferation in response to diverse environmental stimuli. However, senescent cells exhibit strong metabolic activity and release a range of cytokines …
View article: Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis
Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis Open
The identification of oncogenic gene fusions in diffuse gliomas may serve as potential therapeutic targets and prognostic indicators, representing a novel strategy for treating gliomas consistent with the principles of personalized medicin…
View article: Integrated Molecular and Clinical Profiling of 335 Primary Gliomas in Adolescents and Young Adults
Integrated Molecular and Clinical Profiling of 335 Primary Gliomas in Adolescents and Young Adults Open
View article: A ROS‐Responsive Lipid Nanoparticles Release Multifunctional Hydrogel Based on Microenvironment Regulation Promotes Infected Diabetic Wound Healing
A ROS‐Responsive Lipid Nanoparticles Release Multifunctional Hydrogel Based on Microenvironment Regulation Promotes Infected Diabetic Wound Healing Open
The continuous imbalance of the diabetic wound microenvironment is an important cause of chronic nonhealing, which manifests as a vicious cycle between excessive accumulation of reactive oxygen species (ROS) and abnormal healing. Regulatin…
View article: Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine
Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine Open
View article: Enhancing liquid biopsies are a promising approach for the early detection of cancer
Enhancing liquid biopsies are a promising approach for the early detection of cancer Open
Cancer is a formidable threat to human life, a cure for which in advanced stages remains challenging. Early detection and treatment of cancer are paramount, yet a substantial number of cancer patients receive diagnoses at an advanced stage…
View article: Correction: albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis
Correction: albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis Open
View article: Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis
Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis Open
View article: Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder
Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder Open
Depression is a major contributor to poor global health and disability, with a recently increasing incidence. Although drug therapy is commonly used to treat depression, conventional antidepressant drugs have several disadvantages, includi…
View article: A novel mechanism of ferroptosis surveillance offers promising therapeutic avenues for breast and prostate cancers
A novel mechanism of ferroptosis surveillance offers promising therapeutic avenues for breast and prostate cancers Open
View article: Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis
Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis Open
The identification of oncogenic gene fusions in diffuse gliomas may serve as potential therapeutic targets and prognostic indicators, representing a novel strategy for treating gliomas consistent with the principles of personalized medicin…
View article: The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide
The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide Open
Nuclear receptor coactivator 4 (NCOA4) protein is a selective cargo receptor that plays a crucial role in ferritinophagy by targeting and delivering the ferritin iron storage protein to lysosomes for degradation and releasing iron. TRIM7 o…
View article: The PODNL1/AKT/β-catenin signaling axis mediates glioma progression and sensitivity to temozolomide
The PODNL1/AKT/β-catenin signaling axis mediates glioma progression and sensitivity to temozolomide Open
View article: OLFML3, as a potential predictor of prognosis and therapeutic target for glioma, is closely related to immune cell infiltration
OLFML3, as a potential predictor of prognosis and therapeutic target for glioma, is closely related to immune cell infiltration Open
The low response rate to immunosuppressant is mainly due to the lack of adequate knowledge about the tumor microenvironment (TME) and screening biomarkers for gliomas. We aimed to identify the promising immune biomarkers and new immune cla…
View article: A high-throughput sequencing technology for spatial translatomics at the single-cell level
A high-throughput sequencing technology for spatial translatomics at the single-cell level Open
View article: Pathological functions and therapeutic targets of post-translational modifications in pan-cancer
Pathological functions and therapeutic targets of post-translational modifications in pan-cancer Open
View article: Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells
Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells Open
As a transcription factor, the role of CASZ1 in different entities is inconsistent. Glioma is one of the leading causes of cancer death worldwide. Its prognostic relevance and biological functions in glioma remain obscure. We focused on th…
View article: An integrated analysis of <i>C5AR2</i> related to malignant properties and immune infiltration of gliomas
An integrated analysis of <i>C5AR2</i> related to malignant properties and immune infiltration of gliomas Open
Background C5AR2 is recognized as a proinflammatory molecule and activates the inflammatory response in multiple disorders. However, little has been reported on C5AR2 in glioma. This study sought to explore its expression, biological funct…
View article: Roles of Tenascin-XB in the Glioma Immune Microenvironment
Roles of Tenascin-XB in the Glioma Immune Microenvironment Open
Background: Previous studies have reported the critical roles of tumor cells and the tumor microenvironment in tumor prognosis and immunotherapeutic response. However, how Tenascin-XB (TNXB) expression relates to glioma prognosis and to th…
View article: [PD-1 monoclonal antibody combined with chemotherapy in the treatment of subcutaneous panniculitis-like T-cell lymphoma: a case report and literature review].
[PD-1 monoclonal antibody combined with chemotherapy in the treatment of subcutaneous panniculitis-like T-cell lymphoma: a case report and literature review]. Open
View article: The prognostic factors and nomogram for patients with high-grade gliomas
The prognostic factors and nomogram for patients with high-grade gliomas Open
The evaluation on prognosis of glioma patients is critical for the individualized treatment. Despite of the widely used mRNA expression level and methylation status of prognostic genes in predicting the patients’ prognosis, the clinical ap…
View article: EVA1C Is a Potential Prognostic Biomarker and Correlated With Immune Infiltration Levels in WHO Grade II/III Glioma
EVA1C Is a Potential Prognostic Biomarker and Correlated With Immune Infiltration Levels in WHO Grade II/III Glioma Open
Background Immunotherapy is an effective therapeutic approach for multiple human cancer types. However, the correlations between EVA1C and patients’ prognosis as well as immune infiltration remain obscure. Herein, we employed transcriptomi…
View article: EVA1B to Evaluate the Tumor Immune Microenvironment and Clinical Prognosis in Glioma
EVA1B to Evaluate the Tumor Immune Microenvironment and Clinical Prognosis in Glioma Open
Background Previous research indicated that the tumor cells and microenvironment interactions are critical for the immunotherapeutic response. However, predicting the clinical response to immunotherapy remains a dilemma for clinicians. Hen…
View article: Clinical Studies on Platelet-Rich Plasma Therapy for Chronic Cutaneous Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Clinical Studies on Platelet-Rich Plasma Therapy for Chronic Cutaneous Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Significance: Platelet-rich plasma (PRP) may be a potential drug for treatment of chronic refractory ulcers, which increase the risk of systemic infection and local canceration. However, the efficacy and safety of clinical applicati…
View article: Unlocking the Signal Transduction between Glioma-initiating Cells of Tumor Edge
Unlocking the Signal Transduction between Glioma-initiating Cells of Tumor Edge Open