Shanquan Chen
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View article: Health-related Quality of Life among Children Living with Rare Diseases in China: a Nationwide Study
Health-related Quality of Life among Children Living with Rare Diseases in China: a Nationwide Study Open
A large proportion of rare diseases (RDs) manifest in childhood, posing substantial physical and psychosocial burden on pediatric populations. This study aims to evaluate the health-related quality of life (HRQoL) and associated factors am…
View article: Identifying Important Factors for Depressive Symptom Dynamics in Chinese Middle-Aged and Older Adults Using a Multi-State Transition Model with Feature Selection
Identifying Important Factors for Depressive Symptom Dynamics in Chinese Middle-Aged and Older Adults Using a Multi-State Transition Model with Feature Selection Open
Depressive symptoms are increasingly common in middle-aged and older adults and have become a major public health problem. People may experience transitions across different underlying states due to symptom variability over a course of man…
View article: Capability well-being in mothers and fathers of autistic children: a cross-sectional study from China
Capability well-being in mothers and fathers of autistic children: a cross-sectional study from China Open
Background Parents of autistic children often experience reduced well-being, with most studies focusing on negative outcomes. However, fewer studies have applied capability approach to assess parental abilities to achieve positive function…
View article: Impact of COVID-19 on unmet needs for healthcare in Peru: an interrupted time series analysis
Impact of COVID-19 on unmet needs for healthcare in Peru: an interrupted time series analysis Open
The COVID-19 pandemic affected people’s health and access to healthcare worldwide. Still, little is known about how distinct phases of the pandemic – namely the lockdown period and the period directly after lockdown – impacted these outcom…
View article: Identifying modifiable factors and their joint associations on late-onset schizophrenia risk in the UK Biobank: a prospective exposure-wide association study
Identifying modifiable factors and their joint associations on late-onset schizophrenia risk in the UK Biobank: a prospective exposure-wide association study Open
Background One in four cases of schizophrenia begins in late life, resulting in high unemployment and reduced life expectancy. However, knowledge of the modifiable risk factors for late-onset schizophrenia and their combined effects is lim…
View article: Machine learning and natural language processing for the early detection of potential mental disorders among school-age children: a prospective birth cohort study
Machine learning and natural language processing for the early detection of potential mental disorders among school-age children: a prospective birth cohort study Open
Background: Early detection of childhood mental health disorders remains challenging due to gaps in current screening approaches that lack sensitivity to subtle psychological indicators and rely heavily on observable behaviors. We investig…
View article: Identifying High-Risk Adolescents for Mental Health Difficulties: A Machine Learning Analysis of the Health Behaviour in School-aged Children Study Across 46 Countries
Identifying High-Risk Adolescents for Mental Health Difficulties: A Machine Learning Analysis of the Health Behaviour in School-aged Children Study Across 46 Countries Open
Background: Adolescent mental health represents a global public health crisis, yet traditional surveillance methods lack the scalability and predictive power needed for effective early identification. This study aimed to develop and valida…
View article: Editorial: Neurological mechanisms of empathy for distress
Editorial: Neurological mechanisms of empathy for distress Open
View article: How policymakers value end-of-life treatments for rare and common diseases in China: evidence from a contingent valuation study
How policymakers value end-of-life treatments for rare and common diseases in China: evidence from a contingent valuation study Open
Background Understanding policymakers’ value judgements in reimbursement decisions is essential for promoting equity and guiding informed healthcare decision-making. This study aimed to estimate and compare Chinese policymakers’ willingnes…
View article: Discontinuity of social support among US adults with cognitive impairment before and after the confirmed diagnosis of dementia: a matched ambidirectional cohort study
Discontinuity of social support among US adults with cognitive impairment before and after the confirmed diagnosis of dementia: a matched ambidirectional cohort study Open
Background Despite increased attention on dementia, much remains unknown about the integration of clinical and non-clinical care, particularly regarding long-term social support, a primary source of non-clinical care. This study uniquely e…
View article: Prevalence and progress of underdiagnosis of probable dementia: a repeated cross-sectional study in 19 European countries
Prevalence and progress of underdiagnosis of probable dementia: a repeated cross-sectional study in 19 European countries Open
View article: Antibiotic use for common illnesses in children living with disability: a multi-country study across 42 low- and middle-income countries
Antibiotic use for common illnesses in children living with disability: a multi-country study across 42 low- and middle-income countries Open
This research was partially supported by National Natural Science Foundation of China (grant number: 72374228, 72074234), Guangdong Basic and Applied Basic Research Foundation (grant number: 2023A1515010163), Guangzhou Basic and Applied Ba…
View article: Evaluation of health impacts of a disability-inclusive graduation programme among ultra-poor people with disabilities in Uganda: secondary analysis of a cluster randomized trial
Evaluation of health impacts of a disability-inclusive graduation programme among ultra-poor people with disabilities in Uganda: secondary analysis of a cluster randomized trial Open
View article: Disparities in deworming coverage between children with and without disabilities: insights from the DeWorm3 trial in India
Disparities in deworming coverage between children with and without disabilities: insights from the DeWorm3 trial in India Open
Background Children with disabilities experience lower school enrollment rates and may be systematically excluded from school-based deworming programs. The DeWorm3 trial provided an opportunity to evaluate whether community-wide mass drug …
View article: The Development of an Evidence-Based App to Predict the Need for Enhanced Care for People with Dementia
The Development of an Evidence-Based App to Predict the Need for Enhanced Care for People with Dementia Open
Aims: Dementia is a pressing global health challenge affecting more than 50 million people worldwide with a net impact on the global economy of 1 trillion USD. One aspect of the condition is the potential for deterioration to the point whe…
View article: Mortality and its predictors among people with dementia receiving psychiatric in-patient care
Mortality and its predictors among people with dementia receiving psychiatric in-patient care Open
Background Although dementia is a terminal condition, palliation can be a challenge for clinical services. As dementia progresses, people frequently develop behavioural and psychological symptoms, sometimes so severe they require care in s…
View article: Disability-inclusive graduation programme intervention on social participation among ultra-poor people with disability in North Uganda: a cluster randomized trial
Disability-inclusive graduation programme intervention on social participation among ultra-poor people with disability in North Uganda: a cluster randomized trial Open
View article: Does war moderate the association between mental wellbeing and its predictors among children? A multi-country cross-sectional study
Does war moderate the association between mental wellbeing and its predictors among children? A multi-country cross-sectional study Open
Background This study explores how war or conflict influences the established predictors of mental well-being among children, addressing a significant gap in current research. Methods Utilizing data from Multiple Indicator Cluster Surveys …
View article: Impact of long-term care insurance on medical expenditure and utilization and the comparison between different pilot schemes: evidence from China
Impact of long-term care insurance on medical expenditure and utilization and the comparison between different pilot schemes: evidence from China Open
View article: Impact of all-oral bedaquiline-based shorter regimens in the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis
Impact of all-oral bedaquiline-based shorter regimens in the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis Open
Background Drug-resistant tuberculosis (DR-TB) presents a significant global obstacle to TB control efforts, necessitating improved intervention strategies. The introduction of potent drugs, such as bedaquiline (Bdq), has led to the develo…
View article: Network analysis of functional disabilities and their association with mental well-being in children and adolescents: multi-country study across low- and middle-income countries
Network analysis of functional disabilities and their association with mental well-being in children and adolescents: multi-country study across low- and middle-income countries Open
Background To develop effective mental health interventions for children and adolescents, it is essential to understand the intricate link between functional disability and mental well-being in this group. Aims To explore the network conne…
View article: Point-of-care testing reduces antibiotic prescribing in acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis
Point-of-care testing reduces antibiotic prescribing in acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis Open
We offered reasonable evidence for using POCT to reduce antibiotic exposure for AECOPD without adversely affecting clinical outcomes. As diagnostic techniques become increasingly important in combating antimicrobial resistance, the use of …
View article: Absence of care among community-dwelling older adults with dementia and functional limitations
Absence of care among community-dwelling older adults with dementia and functional limitations Open
View article: Economic burden of myasthenia gravis in China: a nationwide registry-based study
Economic burden of myasthenia gravis in China: a nationwide registry-based study Open
Population with MG in China reported heavy economic burdens related to medication. Disease severity is a major driving factor of both direct and indirect costs. Targeted policies are needed to alleviate the financial burden of MG on patien…
View article: Development and validation of a dynamic nomogram for predicting cognitive impairment risk in older adults with dentures: analysis from CHARLS and CLHLS data
Development and validation of a dynamic nomogram for predicting cognitive impairment risk in older adults with dentures: analysis from CHARLS and CLHLS data Open
Five risk factors, including age, place of residence, education, instrumental activities of daily living, and depression level, were selected as the final nomogram to predict the risk of cognitive impairment in elderly denture wearers. The…
View article: Superior electron transport in the single-crystalline TiCoSb-based half-Heuslers
Superior electron transport in the single-crystalline TiCoSb-based half-Heuslers Open
View article: Impact of diagnosis-related group payment on medical expenditure and treatment efficiency on people with drug-resistant tuberculosis: a quasi-experimental study design
Impact of diagnosis-related group payment on medical expenditure and treatment efficiency on people with drug-resistant tuberculosis: a quasi-experimental study design Open
The DRG payment method can effectively control the increase of DR-TB patients' medical expenditure and improve treatment efficiency with the guarantee of care quality. Furthermore, there was no evidence of spillover effects of DRG payment …
View article: Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review
Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review Open
Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whether existing medications for other conditions may …
View article: Absence of Care Among Community-Living Older Persons with Dementia and Disabilities: A Cross-National Analysis of Population Survey from 22 Countries
Absence of Care Among Community-Living Older Persons with Dementia and Disabilities: A Cross-National Analysis of Population Survey from 22 Countries Open
View article: Association between adherence to behavioral intervention and capability well-being among parents of autistic children: a cross-sectional study from China
Association between adherence to behavioral intervention and capability well-being among parents of autistic children: a cross-sectional study from China Open