Shanshan Lu
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View article: Targeted modification of cis-elements in the CUL3 gene to restore exon 9 inclusion for treating Gordon syndrome
Targeted modification of cis-elements in the CUL3 gene to restore exon 9 inclusion for treating Gordon syndrome Open
Our findings highlight the therapeutic potential of AA(-9, -10)TT and A18G in CUL3-related Gordon syndrome, suggesting the targeted modification of cis-elements could be an ideal and universal strategy to develop treatments for splicing-re…
View article: REM Density, Leg Movements, and REM Sleep without Atonia: Differentiating Type 1 from Type 2 Narcolepsy Through Polysomnographic Analysis, a Preliminary Study
REM Density, Leg Movements, and REM Sleep without Atonia: Differentiating Type 1 from Type 2 Narcolepsy Through Polysomnographic Analysis, a Preliminary Study Open
While REM density, leg movement index and RSWA show promise for NT1/NT2 differentiation, these findings require validation in cohorts including idiopathic hypersomnia and other central hypersomnolence disorders. The observed electrophysiol…
View article: Risk factors for bile leakage after laparoscopic common bile duct exploration in older patients with choledocholithiasis
Risk factors for bile leakage after laparoscopic common bile duct exploration in older patients with choledocholithiasis Open
BACKGROUND At present, there are few studies on the risk factors for bile leakage after laparoscopic common bile duct exploration (LCBDE) for older patients with choledocholithiasis. AIM To identify the potential risk factors for bile leak…
View article: Monitoring reported SARS-CoV-2 variants to assess the status of COVID-19 epidemics in the low epidemic state
Monitoring reported SARS-CoV-2 variants to assess the status of COVID-19 epidemics in the low epidemic state Open
The reported new confirmed cases of Coronavirus Disease 2019 (COVID-19) nowadays have diminished in their usefulness for assessing the pandemic situation. This study aimed to discover the correlation of Severe Acute Respiratory Syndrome Co…
View article: Retraction Note: Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K/AKT signaling activation
Retraction Note: Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K/AKT signaling activation Open
View article: Levodopa-synergistic CBT intervention improves Parkinson’s disease with anxiety disorder by regulating the BDNF/PI3K/AKT pathway
Levodopa-synergistic CBT intervention improves Parkinson’s disease with anxiety disorder by regulating the BDNF/PI3K/AKT pathway Open
Background Anxiety disorder is one of the most common and disabling neuropsychiatric syndromes in patients with Parkinson’s disease (PD), seriously affecting the quality of life and prognosis of PD patients. Objective The objective of this…
View article: Tuberculosis Caused by Isoniazid-Resistant Strain Was Transmitted from a Woman Undergoing IVFET to Her Fetus by Intrauterine: A Case Report
Tuberculosis Caused by Isoniazid-Resistant Strain Was Transmitted from a Woman Undergoing IVFET to Her Fetus by Intrauterine: A Case Report Open
Clinicians should stay alert for TB in pregnant women who underwent IVFET as well as their neonates. Our case report may improve clinicians' awareness and ability to manage severe TB during the perinatal period.
View article: Methylene Blue Has Strong Extracellular Virucidal Activity Against a SARS-CoV-2-Related Pangolin Coronavirus with No Intracellular or In Vivo Efficacy
Methylene Blue Has Strong Extracellular Virucidal Activity Against a SARS-CoV-2-Related Pangolin Coronavirus with No Intracellular or In Vivo Efficacy Open
Studies have demonstrated that methylene blue exhibits significant antiviral activity against SARS-CoV-2 or related coronaviruses at the cellular level, suggesting its potential as an anti-SARS-CoV-2 drug. Herein, we report that methylene …
View article: A PD-L1-Targeted Probe Cy5.5-A11 for <i>In Vivo</i> Imaging of Multiple Tumors
A PD-L1-Targeted Probe Cy5.5-A11 for <i>In Vivo</i> Imaging of Multiple Tumors Open
PD-L1 is an immune checkpoint molecule mediating cancer immune escape, and its expression level in the tumor has been used as a biomarker to predict response to immune checkpoint inhibitor (ICI) therapy. Our previous study reveals that an …
View article: Perfusion deficit and vessel wall characteristics to predict recurrent ischemic events in medically treated patients with chronic symptomatic anterior circulation large vessel occlusion
Perfusion deficit and vessel wall characteristics to predict recurrent ischemic events in medically treated patients with chronic symptomatic anterior circulation large vessel occlusion Open
Background To investigate the association between perfusion deficit, vessel wall characteristics, and risk of recurrent ischemic events in medically treated patients with chronic symptomatic anterior circulation large vessel occlusion. Met…
View article: The application of rhubarb concoctions in traditional Chinese medicine and its compounds, processing methods, pharmacology, toxicology and clinical research
The application of rhubarb concoctions in traditional Chinese medicine and its compounds, processing methods, pharmacology, toxicology and clinical research Open
Objective This study reviews the development of rhubarb processing and the current status of pharmacological research. We summarized the effects of different processing methods on the active compounds, pharmacological effects, and toxicity…
View article: Zona incerta mediates early life isoflurane-induced fear memory deficits
Zona incerta mediates early life isoflurane-induced fear memory deficits Open
The potential long-term effects of anesthesia on cognitive development, especially in neonates and infants, have raised concerns. However, our understanding of its underlying mechanisms and effective treatments is still limited. In this st…
View article: Complications and adverse events of high-intensity focused ultrasound in its application to gynecological field - a systematic review and meta-analysis
Complications and adverse events of high-intensity focused ultrasound in its application to gynecological field - a systematic review and meta-analysis Open
The common AEs after HIFU surgery are mostly mild and controllable, and the incidence of serious complications is extremely low. By reasonable prevention and active intervention, these events can be further reduced, making it a safe and ef…
View article: Validation of a one-step genomics-based molecular classifier for endometrial carcinoma in a large Chinese population
Validation of a one-step genomics-based molecular classifier for endometrial carcinoma in a large Chinese population Open
Chinese ECs exhibit distinctive molecular attributes. For accurate molecular subtyping of Chinese ECs, additional molecular markers that align with the Chinese population's characteristics should be incorporated into existing classifiers. …
View article: An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)
An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) Open
SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) is highly attenuated, but can cause mortality in a specifically designed human ACE2-transgenic mouse model, making it an invaluable surrogate model for evaluating the efficacy of d…
View article: Aneurysmal subarachnoid hemorrhage complicating spinal subarachnoid hematoma causing acute cauda equina syndrome: a case report
Aneurysmal subarachnoid hemorrhage complicating spinal subarachnoid hematoma causing acute cauda equina syndrome: a case report Open
View article: Magnetic Resonance Imaging Features Associated with a High and Low Expression of Tumor-Infiltrating Lymphocytes: A Stratified Analysis According to Molecular Subtypes
Magnetic Resonance Imaging Features Associated with a High and Low Expression of Tumor-Infiltrating Lymphocytes: A Stratified Analysis According to Molecular Subtypes Open
A total of 457 patients, including 241 HR+/HER2− patients, 134 HER2+ patients, and 82 TN patients, were studied. The percentage of TILs in the stroma adjacent to the tumor cells was assessed using a 10% cutoff. The low TIL percentages were…
View article: [METTL3 inhibitor STM2457 improves metabolic dysfunction-associated fatty liver disease by regulating mitochondrial function in mice].
[METTL3 inhibitor STM2457 improves metabolic dysfunction-associated fatty liver disease by regulating mitochondrial function in mice]. Open
The METTL3 inhibitor STM2457 improves MAFLD by reducing high-fat diet-induced mitochondrial damage in mice.
View article: A potential broad-spectrum live-attenuated SARS-CoV-2 vaccine derived from pangolin coronavirus and insights into the immune evasion mechanisms of XBB.1.16 variant
A potential broad-spectrum live-attenuated SARS-CoV-2 vaccine derived from pangolin coronavirus and insights into the immune evasion mechanisms of XBB.1.16 variant Open
Harnessing SARS-CoV-2 related viruses from wild animals for live vaccines is an underexplored but promising approach, akin to the vaccinia virus used against smallpox. This study evaluated the potential of a live-attenuated vaccine derived…
View article: Prognostic value of venous outflow profiles on multiphase CT angiography for the patients with acute ischemic stroke after endovascular thrombectomy
Prognostic value of venous outflow profiles on multiphase CT angiography for the patients with acute ischemic stroke after endovascular thrombectomy Open
Objectives: To evaluate the prognostic value of venous outflow (VO) profiles evaluated on multiphase CTA (mCTA) for the patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT). Methods: We retrospectively collected …
View article: Real-time risk ranking of emerging epidemics based on optimized moving average prediction limit—taking the COVID-19 pandemic as an example
Real-time risk ranking of emerging epidemics based on optimized moving average prediction limit—taking the COVID-19 pandemic as an example Open
Background Mathematical models to forecast the risk trend of the COVID-19 pandemic timely are of great significance to control the pandemic, but the requirement of manual operation and many parameters hinders their efficiency and value for…
View article: NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA
NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA Open
Major depressive disorder (MDD) is characterized by diverse debilitating symptoms that include loss of motivation and anhedonia. If multiple medications, psychotherapy, and electroconvulsive therapy fail in some patients with MDD, their co…
View article: Ultrastructural modifications induced by an attenuated SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) in Vero cells
Ultrastructural modifications induced by an attenuated SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) in Vero cells Open
Background Positive-strand RNA viruses, such as SARS-CoV-2, manipulate host cell endomembranes to form viral replication organelles (vROs) for replication and protection. Pangolin coronavirus GX_P2V(short_3UTR), a cell-culture-adapted SARS…
View article: Coxiella burnetii from cell and axenic cultures has similar viability but varied vitality as measured by using a methylcellulose semi-solid medium
Coxiella burnetii from cell and axenic cultures has similar viability but varied vitality as measured by using a methylcellulose semi-solid medium Open
The invention of axenic media for culturing Coxiella burnetii has greatly promoted studies on this fastidious bacterium. In this study, we report a methylcellulose-supplemented ACCM-2 medium that allows the enumeration of C. burnetii colon…
View article: Omicron breakthrough infections in wild-type SARS-CoV-2 vaccinees elicit high levels of neutralizing antibodies against pangolin coronavirus GX_P2V
Omicron breakthrough infections in wild-type SARS-CoV-2 vaccinees elicit high levels of neutralizing antibodies against pangolin coronavirus GX_P2V Open
Omicron BF.7 became the predominant SARS-CoV-2 variant in Beijing after the adjustment of COVID-19 response strategies in December 2022. The ability of antibodies elicited by BF.7 infection to cross-react with SARS-CoV-2-like viruses is un…
View article: Data from MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance by Targeting A20/NF-κB Signaling Pathway
Data from MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance by Targeting A20/NF-κB Signaling Pathway Open
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA regulates this phenomenon. In this study, we investigated the function and mechanism of miR-125b in NPC radioresistanc…
View article: Data from MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance by Targeting A20/NF-κB Signaling Pathway
Data from MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance by Targeting A20/NF-κB Signaling Pathway Open
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA regulates this phenomenon. In this study, we investigated the function and mechanism of miR-125b in NPC radioresistanc…
View article: Extraction, structural characterization, and biological activities of a new glucan from Codonopsis pilosula
Extraction, structural characterization, and biological activities of a new glucan from Codonopsis pilosula Open
View article: ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers
ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers Open
Background Immune checkpoint inhibitors (ICIs) therapy targeting programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) shows promising clinical benefits. However, the relatively low response rate highlights the need to deve…
View article: Anti‐Coronaviral Nanocluster Restrain Infections of SARS‐CoV‐2 and Associated Mutants through Virucidal Inhibition and 3CL Protease Inactivation
Anti‐Coronaviral Nanocluster Restrain Infections of SARS‐CoV‐2 and Associated Mutants through Virucidal Inhibition and 3CL Protease Inactivation Open
Antivirals that can combat coronaviruses, including SARS‐CoV‐2 and associated mutants, are urgently needed but lacking. Simultaneously targeting the viral physical structure and replication cycle can endow antivirals with sustainable and b…