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View article: Systemic T-cell and humoral responses against cancer testis antigens in hepatocellular carcinoma patients
Systemic T-cell and humoral responses against cancer testis antigens in hepatocellular carcinoma patients Open
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide due to high recurrence rates after curative treatment and being frequently diagnosed at an advanced stage. Immune-checkpoint inhibition (ICPI) ha…
View article: Activated CD4+ T Cells and Highly Differentiated Alloreactive CD4+ T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients
Activated CD4+ T Cells and Highly Differentiated Alloreactive CD4+ T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients Open
Spontaneous operational tolerance to the allograft develops in a proportion of liver transplantation (LT) recipients weaned off immunosuppressive (IS) drugs. Several studies have investigated whether peripheral blood circulating T cells co…
View article: Expression of Cancer Testis Antigens in Tumor-Adjacent Normal Liver Is Associated with Post-Resection Recurrence of Hepatocellular Carcinoma
Expression of Cancer Testis Antigens in Tumor-Adjacent Normal Liver Is Associated with Post-Resection Recurrence of Hepatocellular Carcinoma Open
High recurrence rates after resection of hepatocellular carcinoma (HCC) with curative intent impair clinical outcomes of HCC. Cancer/testis antigens (CTAs) are suitable targets for cancer immunotherapy if selectively expressed in tumor cel…
View article: Expression of Cancer testis Antigens in Tumor-adjacent Normal Liver Predicts Post-resection Recurrence of Hepatocellular Carcinoma
Expression of Cancer testis Antigens in Tumor-adjacent Normal Liver Predicts Post-resection Recurrence of Hepatocellular Carcinoma Open
Background: High recurrence rates after resection of hepatocellular cancer (HCC) with curative intent and lack of effective therapy for advanced disease impair clinical outcomes of HCC. Cancer/testis antigens (CTAs) are suitable targets fo…
View article: GITR ligation enhances functionality of tumor‐infiltrating T cells in hepatocellular carcinoma
GITR ligation enhances functionality of tumor‐infiltrating T cells in hepatocellular carcinoma Open
No curative treatment options are available for advanced hepatocellular carcinoma (HCC). Anti‐PD1 antibody therapy can induce tumor regression in 20% of advanced HCC patients, demonstrating that co‐inhibitory immune checkpoint blockade has…
View article: Prognostic value of intra‐tumoral CD8<sup>+</sup>/FoxP3<sup>+</sup> lymphocyte ratio in patients with resected colorectal cancer liver metastasis
Prognostic value of intra‐tumoral CD8<sup>+</sup>/FoxP3<sup>+</sup> lymphocyte ratio in patients with resected colorectal cancer liver metastasis Open
Background and Objectives Patients with isolated colorectal‐cancer‐liver‐metastases (CRCLM) frequently undergo metastatectomy. Tumor‐infiltrating‐lymphocytes (TILs) have prognostic potential in the setting of primary colorectal cancer, how…
View article: Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer
Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer Open
Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality…
View article: Tumor cell expression of immune inhibitory molecules and tumor-infiltrating lymphocyte count predict cancer-specific survival in pancreatic and ampullary cancer
Tumor cell expression of immune inhibitory molecules and tumor-infiltrating lymphocyte count predict cancer-specific survival in pancreatic and ampullary cancer Open
Understanding the mechanisms of immune resistance in pancreatic and ampullary cancers is crucial for the development of suitable biomarkers and effective immunotherapeutics. Our aim was to examine the expression of the immune inhibiting mo…
View article: PD-L1, Galectin-9 and CD8<sup>+</sup> tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma
PD-L1, Galectin-9 and CD8<sup>+</sup> tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma Open
Novel systemic treatments for hepatocellular carcinoma (HCC) are strongly needed. Immunotherapy is a promising strategy that can induce specific antitumor immune responses. Understanding the mechanisms of immune resistance by HCC is crucia…
View article: Relative contributions of naïve and memory T cells to the allo-response in CFSE-MLR upon stimulation with CD40-B cells.
Relative contributions of naïve and memory T cells to the allo-response in CFSE-MLR upon stimulation with CD40-B cells. Open
CFSE-labelled naïve CD3+CD45RA+and CD3+CD45RO+ memory T cells were isolated from PBMC of healthy individuals by flowcytometric sorting, and stimulated with allogeneic CD40-B cells for 6 days. A. Purity of CD3+CD45RO+ and CD3+CD45RA+ T cell…
View article: Comparison of IFN-γ production by T cells in CFSE-MLR before and 1 year after LTx.
Comparison of IFN-γ production by T cells in CFSE-MLR before and 1 year after LTx. Open
CFSE-labeled PBMC from 5 LTx-patients were stimulated with donor-derived or 3rd party CD40-B cells, and re-stimulated with the same allo-antigens at day 5 of culture for 24 hours. During the last 15 hours Brefeldin A was added, and CFSE-di…
View article: Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen
Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen Open
The chronic presence of viral Ags can induce T cell exhaustion, which is characterized by upregulation of coinhibitory receptors and loss of T cell function. We studied whether a similar phenomenon occurs after liver transplantation (LTx),…
View article: Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors
Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors Open
CD4+ type 1 T regulatory (Tr1) cells have a crucial role in inducing tolerance. Immune regulation by these cells is mainly mediated through the secretion of high amounts of IL-10. Several studies have suggested that this regulatory populat…