Shanzhong Zhang
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View article: Integration of Systemic Inflammation Response Index (SIRI) and clinicopathological factors enhances survival prediction in colorectal cancer: A retrospective cohort study
Integration of Systemic Inflammation Response Index (SIRI) and clinicopathological factors enhances survival prediction in colorectal cancer: A retrospective cohort study Open
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. The current tumor-node-metastasis (TNM) staging systems exhibit limited prognostic accuracy because they do not account for host inflammatory responses. This…
View article: Preoperative Gastric Cancer Immune Prognostic Score (GCIPS) as a Novel Biomarker for Predicting Survival in Gastric Cancer Patients After Radical Resection
Preoperative Gastric Cancer Immune Prognostic Score (GCIPS) as a Novel Biomarker for Predicting Survival in Gastric Cancer Patients After Radical Resection Open
Background This study aimed to validate the preoperative Gastric Cancer Immune Prognostic Score (GCIPS) as a prognostic biomarker in resectable gastric cancer (GC).Methods We retrospectively analyzed 226 GC patients undergoing radical rese…
View article: Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study
Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study Open
Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide. The present study aimed to investigate the value of the preoperative C-reactive protein-albumin-lymphocyte (CALLY) index in predicting recurrence-free survival…
View article: Integration of Systemic Inflammation Response Index (SIRI) and Clinicopathological Factors Enhances Survival Prediction in Colorectal Cancer: A Retrospective Cohort Study
Integration of Systemic Inflammation Response Index (SIRI) and Clinicopathological Factors Enhances Survival Prediction in Colorectal Cancer: A Retrospective Cohort Study Open
Background Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. The current TNM staging systems exhibit limited prognostic accuracy because they do not account for host inflammatory responses. This study aimed …
View article: Usefulness of the preoperative Prognostic Immune and Nutritional Index as a prognostic predictor for patients with gastric cancer
Usefulness of the preoperative Prognostic Immune and Nutritional Index as a prognostic predictor for patients with gastric cancer Open
The Prognostic Immune and Nutritional Index (PINI), integrating albumin and monocyte counts, has emerged as a potential prognostic biomarker in gastrointestinal cancer. The present study aimed to evaluate its predictive value in patients w…
View article: A Double‐Blind, Placebo‐Controlled, Single‐Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT‐101, an RNAi Therapeutic Targeting HBV Infection
A Double‐Blind, Placebo‐Controlled, Single‐Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT‐101, an RNAi Therapeutic Targeting HBV Infection Open
HT‐101, a liver‐targeted N‐acetylgalactosamine‐conjugated ribonucleic acid interference therapeutic, exhibits promising potential for the treatment of chronic hepatitis B virus infection. This randomized, double‐blind, placebo‐controlled, …
View article: Updated systematic review and meta‑analysis for risk predictors of 30‑day unplanned readmission following gastric cancer surgery
Updated systematic review and meta‑analysis for risk predictors of 30‑day unplanned readmission following gastric cancer surgery Open
Readmission to hospital is a common occurrence due to adverse post-operative events. The primary objective of the present study was to examine the possible risk predictors for 30-day unplanned readmissions after the surgical treatment of g…
View article: Efficacy and side effects of pembrolizumab plus chemotherapy vs. chemotherapy alone in patients with advanced gastric or gastroesophageal junction adenocarcinoma: A meta‑analysis
Efficacy and side effects of pembrolizumab plus chemotherapy vs. chemotherapy alone in patients with advanced gastric or gastroesophageal junction adenocarcinoma: A meta‑analysis Open
Recently, the treatment plan of pembrolizumab plus chemotherapy was regarded as a promising treatment for patients with advanced gastric cancer or gastroesophageal junction adenocarcinoma (GC/GEJC). However, the efficacy and side effects o…
View article: AAV‐Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness
AAV‐Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness Open
Mutations in OTOFERLIN ( OTOF ) lead to the autosomal recessive deafness 9 (DFNB9). The efficacy of adeno‐associated virus (AAV)‐mediated OTOF gene replacement therapy is extensively validated in Otof ‐deficient mice. However, the clinical…
View article: Comparative Transcriptome Analysis of the Skin and the Peritoneal Wall Layer of Triplophysa stenura Distributed in High Elevations
Comparative Transcriptome Analysis of the Skin and the Peritoneal Wall Layer of Triplophysa stenura Distributed in High Elevations Open
A total of 81,868 All-Unigenes were sequenced and assembled by the transcriptome in the dorsal skin, the lateral skin, and the peritoneal wall layer of Triplophysa stenura with a total assembly length of 123,827,585 bp, and 68,750 unigenes…
View article: Preclinical Efficacy And Safety Evaluation of AAV‐<i>OTOF</i> in DFNB9 Mouse Model And Nonhuman Primate
Preclinical Efficacy And Safety Evaluation of AAV‐<i>OTOF</i> in DFNB9 Mouse Model And Nonhuman Primate Open
OTOF mutations are the principal causes of auditory neuropathy. There are reports on Otof ‐related gene therapy in mice, but there is no preclinical research on the drug evaluations. Here, Anc80L65 and the mouse hair cell‐specific Myo15 pr…
View article: Analysis of Large Vehicle Interference on Transiting Test for Measuring Building Wind Pressure Coefficient
Analysis of Large Vehicle Interference on Transiting Test for Measuring Building Wind Pressure Coefficient Open
As a new method for structural wind engineering research, the transiting test has good application prospects. However, in the road environment, the experimental results will inevitably be influenced by other vehicles (especially larger veh…