Sangang He
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View article: Rapid SNP genotyping detection method based on PCR-lateral flow dipstick detection technique
Rapid SNP genotyping detection method based on PCR-lateral flow dipstick detection technique Open
This study established a polymerase chain reaction-lateral flow dipstick (PCR-LFD) method for the visual detection of SNP genotypes. Targeting the MC4R gene SNP g.732 C > G, highly specific primers were designed for the mutation site, inco…
View article: Inbreeding patterns and genetic diversity under selection in Teha sheep
Inbreeding patterns and genetic diversity under selection in Teha sheep Open
Background Inbreeding and genetic diversity are critical factors influencing the adaptability, productivity, and sustainability of livestock populations. Teha sheep, a crossbred line between Texel and Kazakh sheep, are an important meat-pr…
View article: Novel polymorphism at <i>ARHGAP24</i> gene and its association with growth traits in Hu sheep
Novel polymorphism at <i>ARHGAP24</i> gene and its association with growth traits in Hu sheep Open
It is essential to identify potential genes and genetic variants associated with growth traits to enhance sheep breeding. Previous studies have suggested that the Rho GTPase-activating protein 24 (ARHGAP24) gene may influence the gr…
View article: Identification of microsatellites and their effect on economic traits of Texel × Kazakh sheep
Identification of microsatellites and their effect on economic traits of Texel × Kazakh sheep Open
Introduction Mutton has the advantages of delicious taste, high nutrition, and easy digestion. It is important to improve the production and quality of mutton in mutton sheep breeding. Microsatellite locus marker-assisted breeding is widel…
View article: Young fibroblast-derived migrasomes alleviate keratinocyte senescence and enhance wound healing in aged skin
Young fibroblast-derived migrasomes alleviate keratinocyte senescence and enhance wound healing in aged skin Open
View article: LLM-based Open Domain Planning by Leveraging Entity-Attribute-Level Domain Models
LLM-based Open Domain Planning by Leveraging Entity-Attribute-Level Domain Models Open
View article: Case report: A pregnant woman with recurrent craniopharyngioma: surgical decision-making and doctor-patient bond
Case report: A pregnant woman with recurrent craniopharyngioma: surgical decision-making and doctor-patient bond Open
Craniopharyngioma is a rare, benign tumor that originates from the pituitary stalk and extends along the pituitary-hypothalamic axis. It can have serious effects due to its location, affecting hormone regulation, vision, and other neurolog…
View article: Genome-Wide Association Study of Body Weight Traits in Texel and Kazakh Crossbred Sheep
Genome-Wide Association Study of Body Weight Traits in Texel and Kazakh Crossbred Sheep Open
Background: Originating from the cold and arid regions of northwestern China, Kazakh sheep are dual-purpose breeds optimized for both meat and fat production. In contrast, Texel sheep are internationally recognized for their high-quality m…
View article: High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition
High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition Open
View article: Optical coherence tomography characteristics in hydroxychloroquine retinopathy and the correlations with visual deterioration in Taiwanese
Optical coherence tomography characteristics in hydroxychloroquine retinopathy and the correlations with visual deterioration in Taiwanese Open
PURPOSE: This study aimed to investigate optical coherence tomography (OCT) characteristics in hydroxychloroquine (HCQ) retinopathy and their correlation with visual acuity among Taiwanese patients. MATERIALS AND METHODS: We retrospectivel…
View article: Regulatory role of N6-Methyladenosine on skeletal muscle development in Hu sheep
Regulatory role of N6-Methyladenosine on skeletal muscle development in Hu sheep Open
N6-Methyladenosine (m6A) RNA modification plays an essential role in many biological processes. To investigate the regulatory role of m6A on the skeletal muscle development in Hu sheep, this study took newborn Hu sheep (b_B Group) and six-…
View article: Genome-Wide Association Analysis of Muscle pH in Texel Sheep × Altay Sheep F2 Resource Population
Genome-Wide Association Analysis of Muscle pH in Texel Sheep × Altay Sheep F2 Resource Population Open
pH was one of the important meat quality traits, which was an important factor affecting the storage/shelf life and quality of meat in meat production. In order to find a way to extend the storage/shelf life, the pH values (pH45min, pH24h,…
View article: Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep Open
The worldwide sheep population comprises more than 1000 breeds. Together, these exhibit a considerable morphological diversity, which has not been extensively investigated at the molecular level. Here, we analyze whole-genome sequencing in…
View article: Molecular identification and phylogenesis analysis of gastrointestinal nematode in different populations of Kazakh sheep
Molecular identification and phylogenesis analysis of gastrointestinal nematode in different populations of Kazakh sheep Open
Three dominant species of gastrointestinal nematodes, Haemonchus contortus , Trichostrongylus spp., and Teladorsagia circumcincta from the various populations of Kazakh sheep were subjected to molecular identification and phylogenetic anal…
View article: Genomic analyses of wild argali, domestic sheep, and their hybrids provide insights into chromosome evolution, phenotypic variation, and germplasm innovation
Genomic analyses of wild argali, domestic sheep, and their hybrids provide insights into chromosome evolution, phenotypic variation, and germplasm innovation Open
Understanding the genetic mechanisms of phenotypic variation in hybrids between domestic animals and their wild relatives may aid germplasm innovation. Here, we report the high-quality genome assemblies of a male Pamir argali ( O . ammon p…
View article: Correction: An epidemiological study of gastrointestinal nematode and Eimeria coccidia infections in different populations of Kazakh sheep
Correction: An epidemiological study of gastrointestinal nematode and Eimeria coccidia infections in different populations of Kazakh sheep Open
[This corrects the article DOI: 10.1371/journal.pone.0251307.].
View article: Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep Open
The worldwide sheep population comprises more than 1000 breeds. Together, these exhibit a considerable morphological diversity, which has not been extensively investigated at the molecular level. Here, we analyze whole-genome sequencing in…
View article: An epidemiological study of gastrointestinal nematode and Eimeria coccidia infections in different populations of Kazakh sheep
An epidemiological study of gastrointestinal nematode and Eimeria coccidia infections in different populations of Kazakh sheep Open
This is an epidemiological study on the gastrointestinal nematode (GIN) and Eimeria coccidia infections in Kazakh sheep and the F1 and F2 generations of Kazakh × Texel sheep crosses. A total of 7599 sheep fecal samples were collected from …
View article: Peer Review #2 of "Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy (v0.2)"
Peer Review #2 of "Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy (v0.2)" Open
Under physiological conditions, retinal pigment epithelium (RPE) is a cellular monolayer composed of mitotically quiescent cells.Tight junctions and adherens junctions maintain the polarity of RPE cells, and are required for cellular funct…
View article: Peer Review #2 of "Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy (v0.1)"
Peer Review #2 of "Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy (v0.1)" Open
Under physiological conditions, retinal pigment epithelium (RPE) is a cellular monolayer composed of mitotically quiescent cells.Tight junctions and adherens junctions maintain the polarity of RPE cells, and are required for cellular funct…
View article: Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep
Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep Open
The high concentration of secondary branched wool follicles is a distinctive feature of the Merino sheep. At present, the molecular control of the development and branching of secondary wool follicles (SF) remains elusive. To reveal the po…
View article: Genome-Wide Scan for Runs of Homozygosity Identifies Candidate Genes Related to Economically Important Traits in Chinese Merino
Genome-Wide Scan for Runs of Homozygosity Identifies Candidate Genes Related to Economically Important Traits in Chinese Merino Open
In this study, we estimated the number, length, and frequency of runs of homozygosity (ROH) in 635 Chinese Merino and identified genomic regions with high ROH frequency using the OvineSNP50 whole-genome genotyping array. A total of 6039 RO…
View article: KGF induces podosome formation via integrin-Erk1/2 signaling in human immortalized oral epithelial cells
KGF induces podosome formation via integrin-Erk1/2 signaling in human immortalized oral epithelial cells Open
Our recent study established the role of integrins in KGF-induced oral epithelial adhesion and rete peg elongation. However, how extracellular matrix remodeling cooperates with the increased epithelial adhesion during rete peg elongation h…
View article: Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9
Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9 Open
Coat color is an important characteristic and economic trait in domestic sheep. Aiming at alteration of Chinese merino sheep coat color by genome manipulation, we disrupted sheep agouti signaling protein gene by CRISPR/Cas9. A total of sev…
View article: Estimates of linkage disequilibrium and effective population sizes in Chinese Merino (Xinjiang type) sheep by genome-wide SNPs
Estimates of linkage disequilibrium and effective population sizes in Chinese Merino (Xinjiang type) sheep by genome-wide SNPs Open
View article: Effects of vertebral number variations on carcass traits and genotyping of Vertnin candidate gene in Kazakh sheep
Effects of vertebral number variations on carcass traits and genotyping of Vertnin candidate gene in Kazakh sheep Open
The variation of thoracolumbar vertebrae number positively associated with the carcass length and carcass weight, especially with the carcass length. VRTN gene polymorphism of the SNP (rs426367238) with significant effect on thoraci…
View article: Oral mucosa rete ridge elongation is dependent, but not impact on integrin signalling
Oral mucosa rete ridge elongation is dependent, but not impact on integrin signalling Open
View article: Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments
Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments Open
Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time fra…