Shaobo Lei
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View article: Investigation of light-induced lacrimation and pupillary responses in episodic migraine
Investigation of light-induced lacrimation and pupillary responses in episodic migraine Open
The purpose of this pilot study was to investigate the light-induced pupillary and lacrimation responses mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) in migraine. Ten participants with episodic migraine and norm…
View article: Severe obstructive sleep apnea diagnosed after non-arteritic anterior ischaemic optic neuropathy in a young man
Severe obstructive sleep apnea diagnosed after non-arteritic anterior ischaemic optic neuropathy in a young man Open
Non-arteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in older individuals but may also occur in younger patients. A 30-year-old man presented with a 2-day history of right eye painless vision …
View article: Binocular Summation in Postillumination Pupil Response Driven by Melanopsin-Containing Retinal Ganglion Cells
Binocular Summation in Postillumination Pupil Response Driven by Melanopsin-Containing Retinal Ganglion Cells Open
To investigate how melanopsin-mediated intrinsically photosensitive retinal ganglion cell (ipRGC) signals are integrated binocularly using chromatic pupillometry. We hypothesized that if the melanopsin system is summative, there will be a …
View article: Ocular Topical Anesthesia Does Not Attenuate Light-Induced Discomfort Using Blue and Red Light Stimuli
Ocular Topical Anesthesia Does Not Attenuate Light-Induced Discomfort Using Blue and Red Light Stimuli Open
Ocular topical anesthesia does not alter the light-induced discomfort thresholds to either blue or red light, suggesting that the melanopsin-containing ophthalmic trigeminal ganglion cells provide little or no significant input in mediatin…
View article: Binocular Summation in the Melanopsin Pathway in Visually Normal Observers
Binocular Summation in the Melanopsin Pathway in Visually Normal Observers Open
Introduction: The development of chromatic pupillometry has propelled significant advances in knowledge of the melanopsin-containing intrinsically photosensitive retinal ganglion cell (ipRGC) light detection pathway. Studies have used open…
View article: A Novel Visual Psychometric Test for Light-Induced Discomfort Using Red and Blue Light Stimuli Under Binocular and Monocular Viewing Conditions
A Novel Visual Psychometric Test for Light-Induced Discomfort Using Red and Blue Light Stimuli Under Binocular and Monocular Viewing Conditions Open
The light-induced discomfort characteristics reported here are consistent with features of the melanopsin-containing intrinsically photosensitive retinal ganglion cell light irradiance pathway, which may mediate photophobia, a prominent fe…
View article: The Relation Between Light-Induced Lacrimation and the Melanopsin-Driven Postillumination Pupil Response
The Relation Between Light-Induced Lacrimation and the Melanopsin-Driven Postillumination Pupil Response Open
The chromatic characteristics and intensity-response of light-induced lacrimation are highly consistent with the features of melanopsin phototransduction. This finding is the first in vivo evidence in humans, supporting the hypothesis that…
View article: Towards a chromatic pupillometry protocol for assessing melanopsin-driven post-illumination pupil response in basic science and clinical investigations
Towards a chromatic pupillometry protocol for assessing melanopsin-driven post-illumination pupil response in basic science and clinical investigations Open
The pupillary light reflex (PLR) is mediated by intrinsically photosensitive retinal ganglions cells (ipRGCs), a sub-group of retinal ganglion cells that contain photopigment melanopsin. Melanopsin activation drives a sustained pupil const…