Shaochen Chen
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View article: Microbial living materials promote coral larval settlement
Microbial living materials promote coral larval settlement Open
The global decline of coral reefs calls for new strategies to rapidly restock coral populations and maintain ecosystem functions and services. Low recruitment success on degraded reefs hampers coral sexual propagation and leads to reduced …
<span>3D</span> printed nerve guidance conduit for biologics‐free nerve regeneration and vascular integration Open
There is a clinical need for an effective nerve guidance conduit to treat peripheral nerve injuries. Many studies have explored different materials and active cues to guide neural regeneration, with some success. However, none have demonst…
View article: Biomimetic chemical microhabitats enhance coral settlement
Biomimetic chemical microhabitats enhance coral settlement Open
Anthropogenic stressors pose substantial threats to the existence of coral reefs. Achieving successful coral recruitment stands as a bottleneck in reef restoration and hybrid reef engineering efforts. Here, we enhance coral settlement thro…
View article: 3D Printed Nerve Guidance Conduit for Biologics-Free Nerve Regeneration and Vascular Integration
3D Printed Nerve Guidance Conduit for Biologics-Free Nerve Regeneration and Vascular Integration Open
There is a clinical need for an effective nerve guidance conduit to treat peripheral nerve injuries. Many studies have explored different materials and active cues to guide neural regeneration, with some success. However, none have demonst…
Machine learning-assisted stiffness prediction in high-cell-density bioprinting Open
Bioprinting of cell-laden hydrogels is a rapidly growing field in tissue engineering. The advent of digital light processing (DLP) three-dimensional (3D) bioprinting technique has revolutionized the fabrication of complex 3D structures. By…
Bacteria-powered living materials enable coral larval settlement Open
The global decline of coral reefs calls for new strategies to rapidly restock coral populations and maintain ecosystem functions and services. Low recruitment success on degraded reefs hampers coral sexual propagation and contributes to li…
3D Printing of Succulent‐Inspired Microneedle Array for Enhanced Tissue Adhesion and Controllable Drug Release Open
Controllable and long‐term release remains a great challenge in current drug delivery systems. Benefiting from their efficient drug loading and painless administration, microneedles (MNs) have emerged as a promising platform for transderma…
View article: 3D Printing of a Biomimetic Myotendinous Junction Assisted by Artificial Intelligence
3D Printing of a Biomimetic Myotendinous Junction Assisted by Artificial Intelligence Open
Workflow for developing an in vitro biomimetic myotendinous junction (MTJ): tissue properties and SEM data are measured (left), informing 3D printing of microstructure and properties (middle). MTJ formation occurs naturally within 2 weeks …
3D bioprinting cowpea mosaic virus as an immunotherapy depot for ovarian cancer prevention in a preclinical mouse model Open
Implantable bioprinted hydrogels loaded with immunostimulatory cowpea mosaic virus (CPMV) were fabricated using digital light processing (DLP) printing technology for ovarian cancer treatment.
Phenotypically complex living materials containing engineered cyanobacteria Open
The field of engineered living materials lies at the intersection of materials science and synthetic biology with the aim of developing materials that can sense and respond to the environment. In this study, we use 3D printing to fabricate…
COVID-19 vaccines based on viral nanoparticles displaying a conserved B-cell epitope show potent immunogenicity and a long-lasting antibody response Open
The COVID-19 pandemic caused by SARS-CoV-2 sparked intensive research into the development of effective vaccines, 50 of which have been approved thus far, including the novel mRNA-based vaccines developed by Pfizer and Moderna. Although li…
3D bioprinting of gene delivery scaffolds with controlled release Open
Localized gene delivery via engineered scaffolds offers spatiotemporal control of the gene vector release. Here, we explored the capability of digital light processing based bioprinting to fabricate 3D scaffolds in hydrogels for controlled…
View article: High cell density and high-resolution 3D bioprinting for fabricating vascularized tissues
High cell density and high-resolution 3D bioprinting for fabricating vascularized tissues Open
Three-dimensional (3D) bioprinting techniques have emerged as the most popular methods to fabricate 3D-engineered tissues; however, there are challenges in simultaneously satisfying the requirements of high cell density (HCD), high cell vi…
Phenotypically Complex Living Materials Containing Engineered Cyanobacteria Open
Summary A cyanobacterial photosynthetic biocomposite material was fabricated using 3D-printing and bioengineered to produce multiple functional outputs in response to an external chemical stimulus. Our investigations show the advantages of…
3D bioprinting of complex tissues in vitro: state-of-the-art and future perspectives Open
The pharmacology and toxicology of a broad variety of therapies and chemicals have significantly improved with the aid of the increasing in vitro models of complex human tissues. Offering versatile and precise control over the cell populat…
View article: Compensating the cell-induced light scattering effect in light-based bioprinting using deep learning
Compensating the cell-induced light scattering effect in light-based bioprinting using deep learning Open
Digital light processing (DLP)-based three-dimensional (3D) printing technology has the advantages of speed and precision comparing with other 3D printing technologies like extrusion-based 3D printing. Therefore, it is a promising biomater…
Characterization of morpho-functional traits in mesophotic corals reveals optimized light capture and photosynthesis Open
The morphology and skeleton architecture of photosynthetic corals modulates the light capture and functioning of the coral-algal symbiosis on shallow-water corals. Since corals can thrive on mesophotic reefs under extreme light-limited con…
Nano and Microscale Light-based 3D Bioprinting for Tissue Engineering and Regenerative Medicine Open
In this talk, I will present our laboratory's recent research efforts in developing micro and nano-scale bioprinting methods to create 3D tissue constructs using a variety of biomaterials and cells.These 3D printed scaffolds are functional…
Rapid 3D BioPrinting of a human iPSC-derived cardiac micro-tissue for high-throughput drug testing Open
With cardiac disease a reigning problem in the world, the need for accurate and high-throughput drug testing is paramount. 3D cardiac tissues are promising models, as they can recapitulate the cell-cell, cell-matrix, and cell-tissue intera…
View article: Rapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity
Rapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity Open
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor characterized by high cellular and molecular heterogeneity, hypervascularization, and innate drug resistance. Cellular components and extracellular matrix (ECM) are the t…