Shaochi Wang
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View article: Role of ILC2s as Potential Effector Cells of IL25-Mediated Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps in China
Role of ILC2s as Potential Effector Cells of IL25-Mediated Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps in China Open
ILC2s function as key effector cells of IL-25 in CRSwNP, promoting type-2 inflammation via the STAT3 signaling pathway. Limonin attenuates this response and may serve as a promising therapeutic agent for CRSwNP by targeting IL-25/STAT3-dri…
View article: Single-cell RNA-seq analysis of mouse carotid artery under disturbed flow and human carotid plaques identifies key cell populations in atherosclerosis development
Single-cell RNA-seq analysis of mouse carotid artery under disturbed flow and human carotid plaques identifies key cell populations in atherosclerosis development Open
Atherosclerosis tends to occur in regions of disturbed blood flow. This study explored how disturbed flow aggravates atherosclerosis using single-cell RNA-seq (scRNA-seq) datasets from mouse carotid arteries under disturbed flow and human …
View article: Photovoltaic Short-Term Output Power Forecast Model Based on Improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise–Kernel Principal Component Analysis–Long Short-Term Memory
Photovoltaic Short-Term Output Power Forecast Model Based on Improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise–Kernel Principal Component Analysis–Long Short-Term Memory Open
To solve the problem of photovoltaic power prediction in areas with large climate changes, this article proposes a hybrid Long Short-Term Memory method to improve the prediction accuracy and noise resistance. It combines the improved compl…
View article: A comparative analysis of MMR immunohistochemistry panels: Evaluating the utility of four-protein versus two-protein panels in endometrial cancer patients
A comparative analysis of MMR immunohistochemistry panels: Evaluating the utility of four-protein versus two-protein panels in endometrial cancer patients Open
The two-protein panel, particularly MSH6/PMS2, offers high sensitivity and negative predictive value, suggesting its potential as a cost-effective alternative to the four-protein panel in MMR testing for endometrial cancer patients.
View article: DNA methylation and gene expression profiling reveal potential association of retinol metabolism related genes with hepatocellular carcinoma development
DNA methylation and gene expression profiling reveal potential association of retinol metabolism related genes with hepatocellular carcinoma development Open
Background Aberrant DNA methylation patterns play a critical role in the development of hepatocellular carcinoma (HCC). However, the molecular mechanisms associated with these aberrantly methylated genes remain unclear. This study aimed to…
View article: Lung regeneration: diverse cell types and the therapeutic potential
Lung regeneration: diverse cell types and the therapeutic potential Open
Lung tissue has a certain regenerative ability and triggers repair procedures after injury. Under controllable conditions, lung tissue can restore normal structure and function. Disruptions in this process can lead to respiratory system fa…
View article: Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma
Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma Open
Early detection of hepatocellular carcinoma (HCC) can greatly improve the survival rate of patients. We aimed to develop a novel marker panel based on cell-free DNA (cfDNA) methylation for the detection of HCC. The differentially methylate…
View article: Recent Advancements in Mechanistic Studies of Palladium- and Nickel-Catalyzed Ethylene Copolymerization with Polar Monomers
Recent Advancements in Mechanistic Studies of Palladium- and Nickel-Catalyzed Ethylene Copolymerization with Polar Monomers Open
The introduction of polar functional groups into polyolefin chain structures creates opportunities to enhance specific properties, such as adhesion, dyeability, printability, compatibility, thermal stability, and electrical conductivity, w…
View article: Strategy to combat biofilms: a focus on biofilm dispersal enzymes
Strategy to combat biofilms: a focus on biofilm dispersal enzymes Open
Bacterial biofilms, which consist of three-dimensional extracellular polymeric substance (EPS), not only function as signaling networks, provide nutritional support, and facilitate surface adhesion, but also serve as a protective shield fo…
View article: DNA methylation and gene expression profiling highlight retinol metabolism's vital role in Hepatocellular carcinoma development
DNA methylation and gene expression profiling highlight retinol metabolism's vital role in Hepatocellular carcinoma development Open
Purpose Abnormal DNA methylation patterns play a critical role in the development of hepatocellular carcinoma (HCC). However, the molecular mechanisms associated with these aberrantly methylated genes remain unclear. In this study, we aime…
View article: Evaluating the performance of a plasma dual-target test developed based on sense-antisense and dual-MGB probe technique for colorectal cancer detection
Evaluating the performance of a plasma dual-target test developed based on sense-antisense and dual-MGB probe technique for colorectal cancer detection Open
Background Detecting colorectal cancer (CRC) via blood-based methylation tests shows good patient compliance and convenience, but some use to fail due to the low abundance of plasma cfDNA fragments. To address this issue, we designed this …
View article: Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma
Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma Open
Early detection of hepatocellular carcinoma (HCC) can greatly improve the survival rate of patients. We aimed to develop a novel marker panel based on cell-free DNA (cfDNA) methylation for the detection of HCC. The differentially methylate…
View article: The endoglycosidase activity of Dispersin B is mediated through electrostatic interactions with cationic poly‐β‐(1→6)‐<i>N</i>‐acetylglucosamine
The endoglycosidase activity of Dispersin B is mediated through electrostatic interactions with cationic poly‐β‐(1→6)‐<i>N</i>‐acetylglucosamine Open
Bacterial biofilms consist of bacterial cells embedded within a self‐produced extracellular polymeric substance (EPS) composed of exopolysaccharides, extra cellular DNA, proteins and lipids. The enzyme Dispersin B (DspB) is a CAZy type 20 …
View article: Robust performance of the methylated NTMT1 and MAP3K14-AS1 dual-target test for colorectal cancer detection in plasma by using sense-antisense and dual-MGB probe technique
Robust performance of the methylated NTMT1 and MAP3K14-AS1 dual-target test for colorectal cancer detection in plasma by using sense-antisense and dual-MGB probe technique Open
Background Blood-based methylation tests showed higher patient compliance and convenience than colonoscopy and stool DNA tests for colorectal cancer (CRC) detection. This study aimed to enhance the performance of plasma markers to detect C…
View article: SYNTHESIS OF PNAG ANALOGS TO PROFILE BIOFILM GLYCOSIDASES
SYNTHESIS OF PNAG ANALOGS TO PROFILE BIOFILM GLYCOSIDASES Open
Bacteria biofilms consisting of surface-attached bacterial communities embedded in an extracellular matrix serve as a defense mechanism for many medically important bacterial species. Exopolysaccharides of partially de-N-acetylated poly-β-…
View article: Anionic amino acids support hydrolysis of poly-β-(1,6)-N-acetylglucosamine exopolysaccharides by the biofilm dispersing glycosidase Dispersin B
Anionic amino acids support hydrolysis of poly-β-(1,6)-N-acetylglucosamine exopolysaccharides by the biofilm dispersing glycosidase Dispersin B Open
The exopolysaccharide poly-β-(1→6)-N-acetylglucosamine (PNAG) is a major structural determinant of bacterial biofilms responsible for persistent and nosocomial infections. The enzymatic dispersal of biofilms by PNAG-hydrolyzing glycosidase…
View article: The role of anionic amino acids in hydrolysis of poly-β-(1,6)-<i>N</i>-acetylglucosamine exopolysaccharides by the biofilm dispersing glycosidase Dispersin B
The role of anionic amino acids in hydrolysis of poly-β-(1,6)-<i>N</i>-acetylglucosamine exopolysaccharides by the biofilm dispersing glycosidase Dispersin B Open
The exopolysaccharide poly- β -(1→6)- N -acetylglucosamine (PNAG) is a major structural determinant of bacterial biofilms responsible for persistent and nosocomial infections. The enzymatic dispersal of biofilms by PNAG-hydrolyzing glycosi…
View article: A practical synthesis of amino limonin/deoxylimonin derivatives as effective mitigators against inflammation and nociception
A practical synthesis of amino limonin/deoxylimonin derivatives as effective mitigators against inflammation and nociception Open
A practical synthetic route, consisting of 5 steps, has been developed and applied successfully for converting limonin/deoxylimonin into the corresponding amino derivatives I-5a–I-5e and II-5a–II-5e.