Shaofen Lin
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View article: Dietary microalgal oligopeptides enhance growth performance, hepatic metabolism, immunity, and gut health in spotted seabass (Lateolabrax maculatus)
Dietary microalgal oligopeptides enhance growth performance, hepatic metabolism, immunity, and gut health in spotted seabass (Lateolabrax maculatus) Open
View article: Clinical characteristics and factors associated with severe COVID-19 among hospitalized pediatric patients: a retrospective cohort study in the Chaoshan region of China
Clinical characteristics and factors associated with severe COVID-19 among hospitalized pediatric patients: a retrospective cohort study in the Chaoshan region of China Open
Background Since 2019, COVID-19 has substantially impacted global public health. Although pediatric cases generally manifest with mild symptoms, severe and even fatal outcomes have occurred. Despite the decreased viral transmissibility and…
View article: A Chinese pediatric patient with thalassemia traits and compound heterozygous mutations in the <i>PIEZO1 g</i> ene suspected of having dehydrated hereditary stomatocytosis
A Chinese pediatric patient with thalassemia traits and compound heterozygous mutations in the <i>PIEZO1 g</i> ene suspected of having dehydrated hereditary stomatocytosis Open
Compared to patients with either DHS/HX or β-thalassemia alone, this patient, as a β-thalassemia carrier with suspected Dehydrated Hereditary Stomatocytosis, exhibited highly complex laboratory findings. Genetic testing played a crucial ro…
View article: Diagnosis and treatment of Diamond-Blackfan anemia and Pierre-Robin sequence caused by a novel mutation of RPS28 gene
Diagnosis and treatment of Diamond-Blackfan anemia and Pierre-Robin sequence caused by a novel mutation of RPS28 gene Open
It is crucial to perform a genetic evaluation for syndromic bone marrow failure with congenital anomalies. A heterozygous mutation in the RPS28 gene (c.2T > C, p.Met1?) is a novel pathogenic mutation associated with DBA. HSCT is an effecti…
View article: A novel conditioning regimen with pre-transplantation immunosuppression reduces the complication rates in hematopoietic stem cell transplantation in transfusion-dependent β-thalassemia
A novel conditioning regimen with pre-transplantation immunosuppression reduces the complication rates in hematopoietic stem cell transplantation in transfusion-dependent β-thalassemia Open
URD transplantation can achieve a comparable prognosis to matched sibling donor (MSD) transplantation with a lower incidence of AIHA due to PTIS and modified myeloablative conditioning regimen.
View article: A Novel Conditioning Regimen with Pre-transplantation Immunosuppression Reduces the Complication Rates in Hematopoietic Stem Cell Transplantation in Transfusion-Dependent β-Thalassemia
A Novel Conditioning Regimen with Pre-transplantation Immunosuppression Reduces the Complication Rates in Hematopoietic Stem Cell Transplantation in Transfusion-Dependent β-Thalassemia Open
Background Allo-HSCT is a curative therapy for patients with transfusion-dependent thalassemia (TDT). The high incidence of transplant-related complications is becoming an obstacle to safe and effective unrelated donor (URD) transplantatio…
View article: Insufficient phosphorylation of STAT5 in Tregs inhibits the expression of BLIMP-1 but not IRF4, reduction the proportion of Tregs in pediatric aplastic anemia
Insufficient phosphorylation of STAT5 in Tregs inhibits the expression of BLIMP-1 but not IRF4, reduction the proportion of Tregs in pediatric aplastic anemia Open
Deficiency in regulatory T cells (Tregs) is an important mechanism underlying the pathogenesis of pediatric aplastic anemia, but its specific mechanism is unclear. In our study, we aimed to investigate whether IL-2/STAT5 can regulate the p…
View article: Insufficient Phosphorylation of Stat5 in Tregs Inhibits the Expression of Blimp-1 But Not Irf4, Reduction the Proportion of Tregs in Pediatric Aplastic Anemia
Insufficient Phosphorylation of Stat5 in Tregs Inhibits the Expression of Blimp-1 But Not Irf4, Reduction the Proportion of Tregs in Pediatric Aplastic Anemia Open
View article: Analysis of clinical characteristics and prognostic factors associated with EBV-associated HLH in children
Analysis of clinical characteristics and prognostic factors associated with EBV-associated HLH in children Open
Purpose Our aim is to analyze the clinical characteristics and prognostic factors of Epstein-Barr (EB) virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) in children. Methods Children with newly diagnosed HLH were retrospectivel…
View article: Clinical Outcome of Acquired Post-Immunosuppressive-Therapy Aplastic Anemia in Pediatric Patients: A 13-Year Experience in Two Southern China Tertiary Care Centers
Clinical Outcome of Acquired Post-Immunosuppressive-Therapy Aplastic Anemia in Pediatric Patients: A 13-Year Experience in Two Southern China Tertiary Care Centers Open
With the use of rabbit anti-thymocyte globulin, proper cyclosporine management, and a prolonged IST follow-up period, a higher number of patients with acquired AA than normal achieved response. Proportionally, the number of patients who ac…
View article: Protective Effect of a Bispecific Fc-Fusion Protein on the Barrier of Human Retinal Pigment Epithelial Cells
Protective Effect of a Bispecific Fc-Fusion Protein on the Barrier of Human Retinal Pigment Epithelial Cells Open
Introduction: The aim of the study was to evaluate the protective effects of IBI302, a bispecific Fc-fusion protein that theoretically can bind vascular endothelial growth factor (VEGF), complement C3b, and C4b in the barrier…
View article: Efficacy and safety of eltrombopag in the treatment of Chinese children with chronic immune thrombocytopenia
Efficacy and safety of eltrombopag in the treatment of Chinese children with chronic immune thrombocytopenia Open
Eltrombopag not only shows excellent initial response but also has continued efficacy and safety. Patients with megakaryocyte count ≥100/slide and Treg<4.5% achieve increased initial response and more frequent durable response.
View article: Features of idiopathic and intermediate uveitis–associated epiretinal membranes on OCT and multi-color imaging
Features of idiopathic and intermediate uveitis–associated epiretinal membranes on OCT and multi-color imaging Open
BACKGROUND To characterize the morphologic features of idiopathic epiretinal membrane (iERM) and subtle intermediate uveitis-associated epiretinal membrane (IU-ERM) using optical coherence tomography (OCT) with multi-color imaging.METHODS …
View article: Berberine Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of AMPK
Berberine Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of AMPK Open
Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly with less effective treatment, especially for dry AMD (90% of AMD). Although the etiology of this disease is not well elucidated, increasing …
View article: Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B
Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B Open
Forkhead box protein O3 (FoxO3a) is a forkhead box family transcription factor which serves an important role in a number of biological functions, including tumor growth. A previous study indicated that FoxO3a serves a role in insulin like…
View article: Correlation analysis of severe aplastic anemia immunosuppressive therapy and human leukocyte antigen alleles in pediatric patients
Correlation analysis of severe aplastic anemia immunosuppressive therapy and human leukocyte antigen alleles in pediatric patients Open
The aim of the present study was to investigate the correlation between the efficacy of immunosuppressive therapy (IST) in children with severe aplastic anemia (SAA) and human leukocyte antigen (HLA) alleles. The polymerase chain reaction-…
View article: The Correlation between Aquaporin-4 Antibody and the Visual Function of Patients with Demyelinating Optic Neuritis at Onset
The Correlation between Aquaporin-4 Antibody and the Visual Function of Patients with Demyelinating Optic Neuritis at Onset Open
ON patients with AQP4-Ab seropositivity tend to be predominantly female and young and have worse visual acuity and more severe damage to their visual fields compared with AQP4-Ab seronegativity.