Shaohui He
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View article: Epigenomic Heterogeneity of Non-Functional Pancreatic Neuroendocrine Tumors Uncovered by Single nucleus and Spatial ATAC Profiling
Epigenomic Heterogeneity of Non-Functional Pancreatic Neuroendocrine Tumors Uncovered by Single nucleus and Spatial ATAC Profiling Open
Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) account for the majority of neuroendocrine neoplasms arising in the pancreas and exhibit substantial clinical and biological heterogeneity, yet their epigenetic regulation and sp…
View article: Deep learning algorithms from histopathological images stratify molecular subtypes for leiomyosarcoma: a proof-and-concept diagnostic study
Deep learning algorithms from histopathological images stratify molecular subtypes for leiomyosarcoma: a proof-and-concept diagnostic study Open
Background: The leiomyosarcoma (LMS) is the most common soft tissue sarcoma, and its molecular subtypes were identified with therapeutic sensitivity and prognosis. We aimed to develop and validate deep learning (DL) algorithms to stratify …
View article: A retrospective study on safety and clinical outcomes of unilateral biportal endoscopic technique for spinal degenerative diseases
A retrospective study on safety and clinical outcomes of unilateral biportal endoscopic technique for spinal degenerative diseases Open
Background and Objective Unilateral biportal endoscopy (UBE) has been developing rapidly in coincidence with the popularization of minimally invasive spine surgery (MISS). However, the clinical outcome and invasiveness of UBE-assisted spin…
View article: A novel histone acetylation-associated gene signature with prognostic value in Ewing Sarcoma
A novel histone acetylation-associated gene signature with prognostic value in Ewing Sarcoma Open
Histone acetylation is an important epigenic modification, modulating the development of many tumors. However, the functions of most Histone acetylation-related genes (HARGs) and their prognostic values in Ewing sarcoma (EWS) remain unclea…
View article: Surgical Treatments and Long-Term Outcomes for Pediatric Patients With Lumbar Spinal Tumors
Surgical Treatments and Long-Term Outcomes for Pediatric Patients With Lumbar Spinal Tumors Open
Study Design Retrospective case‒control study Objectives This study aimed to report the effects of surgical intervention on spinal stability recovery and to assess the long-term outcomes of children and adolescents with lumbar tumors. Meth…
View article: Prognostic factors of sarcomas occurring in bone and joint: A SEER based study
Prognostic factors of sarcomas occurring in bone and joint: A SEER based study Open
To clarify the epidemiology, treatment, and prognosis of sarcomas occurring in the bones and joints. The surveillance, epidemiology, and end results (SEER) 18 registries, comprising sarcoma diagnoses made between 2008 and 2014, were querie…
View article: Measurement properties of health-related quality of life measures for people living with metastatic disease of the spine: a systematic review
Measurement properties of health-related quality of life measures for people living with metastatic disease of the spine: a systematic review Open
Purpose: Patients with spinal metastases (SM) suffer from a significant quality of life (QoL) deterioration. The measurement of QoL has garnered significant attention. In this study, the authors aimed to investigate the frequency of QoL me…
View article: Sacral Ewing sarcoma with rib, lung, and multifocal skull metastases: A rare case report and review of treatments
Sacral Ewing sarcoma with rib, lung, and multifocal skull metastases: A rare case report and review of treatments Open
Ewing sarcoma (ES) rarely derives from the sacrum or mobile spine. The discovery of primary ES with multimetastatic involvements is exceedingly less frequent in clinical practice. A 23-year-old man with initial primary sacral ES developed …
View article: A Novel Defined Hypoxia-Related Gene Signature for Prognostic Prediction of Patients With Ewing Sarcoma
A Novel Defined Hypoxia-Related Gene Signature for Prognostic Prediction of Patients With Ewing Sarcoma Open
The therapeutic strategy of Ewing sarcoma (EWS) remains largely unchanged over the past few decades. Hypoxia is reported to have an impact on tumor cell progression and is regarded as a novel potential therapeutic target in tumor treatment…
View article: [Retracted] Identification of ATG7 as a Regulator of Proferroptosis and Oxidative Stress in Osteosarcoma
[Retracted] Identification of ATG7 as a Regulator of Proferroptosis and Oxidative Stress in Osteosarcoma Open
Background . Ferroptosis has gained significant attention from oncologists as a vital outcome of oxidative stress. The aim of this study was to develop a prognostic signature that was based on the ferroptosis‐related genes (FRGs) for osteo…
View article: Additional file 1 of Surgical efficacy and survival prediction of patients with unspecified malignant bone tumors
Additional file 1 of Surgical efficacy and survival prediction of patients with unspecified malignant bone tumors Open
Additional file 1.
View article: Interdisciplinary Surgical Treatments and Long-Term Outcomes of Lumbar Spinal Tumors With Retroperitoneal Involvements: A Retrospective Case Series Study
Interdisciplinary Surgical Treatments and Long-Term Outcomes of Lumbar Spinal Tumors With Retroperitoneal Involvements: A Retrospective Case Series Study Open
Purpose Surgical treatments are technically challenging for lumbar spinal tumor (LST) with extensive retroperitoneal involvements. Our study aimed to report the experience and outcomes concerning interdisciplinary surgical collaborations i…
View article: Acute spinal cord infarction after multilevel en bloc corpectomy: a case report and literature review
Acute spinal cord infarction after multilevel en bloc corpectomy: a case report and literature review Open
Spinal cord infarction (SCI) is a catastrophic neurologic deficit following spine surgery. Because of the opposite management regimens used for SCI and acute epidural hematoma, accurate diagnosis of SCI is of great importance to maximally …
View article: Clinical features and prognostic factors of spinal fibroblastic/myofibroblastic tumors: a long-term, single-center, retrospective study
Clinical features and prognostic factors of spinal fibroblastic/myofibroblastic tumors: a long-term, single-center, retrospective study Open
Background Spinal fibroblastic and myofibroblastic tumors (FMTs) are extremely rare. Few studies have reported on the features and outcomes of this condition that affects the axial skeleton. We explored the clinical characteristics and fac…
View article: <p>Surgical outcomes and prognostic factors for patients with gastric cancer spinal metastasis</p>
Surgical outcomes and prognostic factors for patients with gastric cancer spinal metastasis Open
Surgery is an efficient option in treating GCSM, due to its efficacy in pain alleviation, function restoration, and stability reconstruction. Low levels of CEA, LDH, ALP, and high Tokuhashi score (>6) are all favorable factors for better O…
View article: Management of brown tumor of spine with primary hyperparathyroidism
Management of brown tumor of spine with primary hyperparathyroidism Open
Rationale: Brown tumor (BT) is a rare benign lesion in skeletal system. It is especially rare secondary to primary hyperparathyroidism (HPT). The differential diagnosis can be misleading due to its diversified clinical characteristics. Fin…
View article: Surgical management and outcome of synovial sarcoma in the spine
Surgical management and outcome of synovial sarcoma in the spine Open
Spinal SS has a relatively high risk of local recurrence and distant metastasis. Surgical intervention can improve the neurological function and relieve pain in these patients. En bloc excision is an effective treatment strategy to improve…
View article: Benign-appearing intra-spinal malignant peripheral nerve sheath tumors (mpnsts): treatments and outcomes of 14 consecutive patients
Benign-appearing intra-spinal malignant peripheral nerve sheath tumors (mpnsts): treatments and outcomes of 14 consecutive patients Open
Benign-appearing intraspinal MPNSTs are relatively rare tumors with a better overall prognosis compared with common spinal MPNSTs. A lot of factors can affect patients" survival and local recurrence. These prognostic factors still require …
View article: Selective Arterial Embolization for the Treatment of Sacral and Pelvic Giant Cell Tumor: A Systematic Review
Selective Arterial Embolization for the Treatment of Sacral and Pelvic Giant Cell Tumor: A Systematic Review Open
Giant cell tumor of the bone ( GCTB ) is a locally aggressive tumor with a certain distant metastatic rate. For sacral GCT ( SGCT ) and pelvic GCT ( PGCT ), surgery has its limitations, especially for unresectable or recurrent tumors. Sele…
View article: An independent evaluation on the interobserver reliability and intraobserver reproducibility of Toyama classification system for cervical dumbbell tumors
An independent evaluation on the interobserver reliability and intraobserver reproducibility of Toyama classification system for cervical dumbbell tumors Open
Dumbbell tumors can not only cause the compression of cervical cord and nerve root, but also invade the important structures and the surrounding organs, causing great harm to the patient. Toyama classification that is commonly used has not…