Shaojun Yu
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View article: Integrating Epigenetic and Phenotypic Features for Biological Age Estimation in Cancer Patients via Multimodal Learning
Integrating Epigenetic and Phenotypic Features for Biological Age Estimation in Cancer Patients via Multimodal Learning Open
Biological age, which may be older or younger than chronological age due to factors such as genetic predisposition, environmental exposures, serves as a meaningful biomarker of aging processes and can inform risk stratification, treatment …
View article: The 3D Genome Browser 2.0: an enhanced online platform for visualizing and analyzing 3D genome architecture
The 3D Genome Browser 2.0: an enhanced online platform for visualizing and analyzing 3D genome architecture Open
The 3D Genome Browser 2.0 (https://3dgenome.fsm.northwestern.edu) is a significantly enhanced online platform designed for the exploration and analysis of 3D genome architecture data, with easy integration with other omics data such as ChI…
View article: EPCO-25. SINGLE-NUCLEUS CO-PROFILING OF TRANSCRIPTOME, HISTONE MODIFICATIONS, AND CHROMATIN ACCESSIBILITY REVEALS DYNAMIC EVOLUTION OF RECURRENT GLIOBLASTOMA
EPCO-25. SINGLE-NUCLEUS CO-PROFILING OF TRANSCRIPTOME, HISTONE MODIFICATIONS, AND CHROMATIN ACCESSIBILITY REVEALS DYNAMIC EVOLUTION OF RECURRENT GLIOBLASTOMA Open
Recent breakthroughs in genome technologies such Paired-Seq and Pair-Tag can jointly profile transcriptome and chromatin accessibility or histone modifications in single cells, and these methods have been used to study cell-type specific r…
View article: Low-Velocity Impact Response and Collision Resistance of Basalt Fiber Reinforced Concrete Bridge Structures
Low-Velocity Impact Response and Collision Resistance of Basalt Fiber Reinforced Concrete Bridge Structures Open
View article: Elevated drain fluid calprotectin as a predictor of early anastomotic leakage in colorectal surgery
Elevated drain fluid calprotectin as a predictor of early anastomotic leakage in colorectal surgery Open
View article: Impact of Nanopore Flow Cell Types on DNA Methylation Detection
Impact of Nanopore Flow Cell Types on DNA Methylation Detection Open
Third-generation sequencing technologies have revolutionized the study of epigenetic characteristics in human diseases, with Oxford Nanopore Technologies (ONT) at the forefront of long-read sequencing. ONT has made rapid improvements in fl…
View article: Long-Read Sequencing Outperforms Short-Read Sequencing in Detecting Most Structural Variations
Long-Read Sequencing Outperforms Short-Read Sequencing in Detecting Most Structural Variations Open
Structural variations (SV) are common in the cancer genome and play critical roles in regulating tumorigenesis. In the past decades, many SVs have been detected through analyses of whole-genome sequencing (WGS) data generated mainly by Ill…
View article: The Factor Structure of Jump Risk
The Factor Structure of Jump Risk Open
View article: Isolation, Purification, Structural Characterization, and Antitumor Activity of Novel Compounds from Tiebangchui
Isolation, Purification, Structural Characterization, and Antitumor Activity of Novel Compounds from Tiebangchui Open
View article: Emerging industry classification based on BERT model
Emerging industry classification based on BERT model Open
View article: A novel classification framework for genome-wide association study of whole brain MRI images using deep learning
A novel classification framework for genome-wide association study of whole brain MRI images using deep learning Open
Genome-wide association studies (GWASs) have been widely applied in the neuroimaging field to discover genetic variants associated with brain-related traits. So far, almost all GWASs conducted in neuroimaging genetics are performed on univ…
View article: Longitudinal multi-omics reveals pathogenic<i>TSC2</i>variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex
Longitudinal multi-omics reveals pathogenic<i>TSC2</i>variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex Open
Tuberous Sclerosis Complex (TSC), an autosomal dominant condition, is caused by heterozygous mutations in either the TSC1 or TSC2 genes, manifesting in systemic growth of benign tumors. In addition to brain lesions, neurologic sequelae rep…
View article: A novel classification framework for genome-wide association study of whole brain MRI images using deep learning
A novel classification framework for genome-wide association study of whole brain MRI images using deep learning Open
Genome-wide association studies (GWASs) have been widely applied in the neuroimaging field to discover genetic variants associated with brain-related traits. So far, almost all GWASs conducted in neuroimaging genetics are performed on univ…
View article: Synthesis of Harmaline N-9 Derivatives and Investigation of in Vitro Anticancer Activity
Synthesis of Harmaline N-9 Derivatives and Investigation of in Vitro Anticancer Activity Open
View article: UI/UX for Generative AI: Taxonomy, Trend, and Challenge
UI/UX for Generative AI: Taxonomy, Trend, and Challenge Open
Current technological advancements in Information Technology are closely linked to Generative Artificial Intelligence, enabling the automation of complex tasks such as generating documents, images, videos, audio, and actions. As such tasks…
View article: Function and mechanism of MCM8 in the development and progression of colorectal cancer
Function and mechanism of MCM8 in the development and progression of colorectal cancer Open
View article: R-Mixup: Riemannian Mixup for Biological Networks
R-Mixup: Riemannian Mixup for Biological Networks Open
Biological networks are commonly used in biomedical and healthcare domains to effectively model the structure of complex biological systems with interactions linking biological entities. However, due to their characteristics of high dimens…
View article: A Review on Knowledge Graphs for Healthcare: Resources, Applications, and Promises
A Review on Knowledge Graphs for Healthcare: Resources, Applications, and Promises Open
This comprehensive review aims to provide an overview of the current state of Healthcare Knowledge Graphs (HKGs), including their construction, utilization models, and applications across various healthcare and biomedical research domains.…
View article: International guideline on natural orifice specimen extraction surgery (NOSES) for colorectal cancer (2023 version)
International guideline on natural orifice specimen extraction surgery (NOSES) for colorectal cancer (2023 version) Open
Purpose In recent years, natural orifice specimen extraction surgery (NOSES) has gained widespread attention as an alternative approach. Although the safety and feasibility of NOSES have been well documented, many questions remain open for…
View article: Efficacy and safety of anlotinib in metastatic colorectal cancer: A systematic review and Meta-analysis
Efficacy and safety of anlotinib in metastatic colorectal cancer: A systematic review and Meta-analysis Open
Objective To systematically evaluate the efficacy and safety of anlotinib for patients with metastatic colorectal cancer (mCRC). Method We searched eligible studies in PubMed, Embase, Cochrane Library, Wanfang Patent Database and China Nat…
View article: Comparison of short-term surgical outcomes and long-term survival between emergency and elective surgery for colorectal cancer: A systematic review and meta-analysis
Comparison of short-term surgical outcomes and long-term survival between emergency and elective surgery for colorectal cancer: A systematic review and meta-analysis Open
Objective: The objective of this study was to summarize relevant data from previous reports and perform a meta-analysis to compare short-term surgical outcomes and long-term oncological outcomes between emergency and elective surgery for c…
View article: KIF15 knockdown inhibits colorectal cancer proliferation and migration through affecting the ubiquitination modification of NRAS.
KIF15 knockdown inhibits colorectal cancer proliferation and migration through affecting the ubiquitination modification of NRAS. Open
As one of the most common malignancies, colorectal cancer (CRC) requires a thorough understanding of the mechanisms that promote its development and the discovery of new therapeutic targets. In this study, immunohistochemical staining conf…
View article: SPLIT: Stance and Persuasion Prediction with Multi-modal on Image and Textual Information
SPLIT: Stance and Persuasion Prediction with Multi-modal on Image and Textual Information Open
Persuasiveness is a prominent personality trait that measures the extent to which a speaker can impact the beliefs, attitudes, intentions, motivations, and actions of their audience. The ImageArg task is a featured challenge at the 10th Ar…
View article: Comparison of short-term surgical outcome and long-term survival between emergency and elective surgery for colorectal cancer: A systematic review and meta-analysis
Comparison of short-term surgical outcome and long-term survival between emergency and elective surgery for colorectal cancer: A systematic review and meta-analysis Open
Background: The objective of this study was to summarize data from previous relevant reports and perform a meta-analysis to compare short-term surgical outcomes and long-term oncological outcomes between emergency resection and elective re…
View article: Neoantigen vaccine and neoantigen‐specific cell adoptive transfer therapy in solid tumors: Challenges and future directions
Neoantigen vaccine and neoantigen‐specific cell adoptive transfer therapy in solid tumors: Challenges and future directions Open
The phenomenon of tumor hierarchy and genetic instability can be explained by the “two‐hits theory” and results in the occurrence of many somatic mutations. The expression of nonsynonymous mutations results in the production of mutant prot…
View article: Short-term and oncological outcomes of natural orifice specimen extraction surgery (NOSES) for colorectal cancer in China: a national database study of 5055 patients
Short-term and oncological outcomes of natural orifice specimen extraction surgery (NOSES) for colorectal cancer in China: a national database study of 5055 patients Open
View article: A novel immune-related lncRNA pair signature for prognostic prediction and immune response evaluation in gastric cancer: a bioinformatics and biological validation study
A novel immune-related lncRNA pair signature for prognostic prediction and immune response evaluation in gastric cancer: a bioinformatics and biological validation study Open
View article: Additional file 1 of A novel immune-related lncRNA pair signature for prognostic prediction and immune response evaluation in gastric cancer: a bioinformatics and biological validation study
Additional file 1 of A novel immune-related lncRNA pair signature for prognostic prediction and immune response evaluation in gastric cancer: a bioinformatics and biological validation study Open
Additional file 1: Table S1. The immune related pathway and genes.
View article: Promoting Effect of Dissolved Organic Matter on the Degradation of Persistent Organic Pollutants by White Rot Fungi
Promoting Effect of Dissolved Organic Matter on the Degradation of Persistent Organic Pollutants by White Rot Fungi Open
The effect of dissolved organic matter on the degradation of white rot fungi plays a certain role from the existing research.It can mainly accelerate the degradation ability of white rot fungi, play a role as a carrier for the transport of…
View article: Additional file 2 of A novel immune-related lncRNA pair signature for prognostic prediction and immune response evaluation in gastric cancer: a bioinformatics and biological validation study
Additional file 2 of A novel immune-related lncRNA pair signature for prognostic prediction and immune response evaluation in gastric cancer: a bioinformatics and biological validation study Open
Additional file 2: Table S2. The results of the univariate Cox proportional hazards regression model.