Shao‐Lan Qin
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View article: Short-term Outcomes of Laparoscopy-Assisted vs Open Surgery for Patients With Low Rectal Cancer
Short-term Outcomes of Laparoscopy-Assisted vs Open Surgery for Patients With Low Rectal Cancer Open
Importance The efficacy of laparoscopic vs open surgery for patients with low rectal cancer has not been established. Objective To compare the short-term efficacy of laparoscopic surgery vs open surgery for treatment of low rectal cancer. …
View article: Lymphadenectomy Around Inferior Mesenteric Artery in Low-Tie vs High-Tie Laparoscopic Anterior Resection: Short- and Long-Term Outcome of a Cohort of 614 Rectal Cancers
Lymphadenectomy Around Inferior Mesenteric Artery in Low-Tie vs High-Tie Laparoscopic Anterior Resection: Short- and Long-Term Outcome of a Cohort of 614 Rectal Cancers Open
The LT with preservation of left colic artery had similar lymph node yield, but lower leakage and complications than HT in laparoscopic anterior resections for rectal cancers. The long-term 3- and 5-year overall and disease-free survival w…
View article: AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner
AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner Open
Absent in melanoma 2 (AIM2), a DNA sensor that plays an important role in natural immunity system, has been reported to participate in colorectal cancer (CRC) development. However, the functional role of AIM2 in BRAF-mutant CRC remains unc…
View article: Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA‐124‐3p/STAT3/RelA signalling pathway in ulcerative colitis
Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA‐124‐3p/STAT3/RelA signalling pathway in ulcerative colitis Open
Ulcerative colitis (UC) is a multifactorial inflammatory disease, and increasing evidence has demonstrated that the mechanism of UC pathogenesis is associated with excessive cellular apoptosis and reactive oxygen species (ROS) production. …
View article: SIRT1 promotes EMT, migration and invasion by regulating mTORC1/4E-BP1 in colorectal cancer
SIRT1 promotes EMT, migration and invasion by regulating mTORC1/4E-BP1 in colorectal cancer Open
Background Metastasis, rather than primary tumors, was accounted for the most cases of cancer death in colorectal cancer(CRC). The understanding of the underlying mechanism associated with tumor metastasis would improve the patient’s miser…
View article: Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages
Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages Open
Background/Aims: ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are a family of extracellular proteases that have been related to both oncogenic and tumor-suppressive functions. The aim of the present study…
View article: Expression of CHD5 may serve as an independent biomarker of prognosis in colorectal cancer via immunohistochemical staining.
Expression of CHD5 may serve as an independent biomarker of prognosis in colorectal cancer via immunohistochemical staining. Open
Chromodomain helicase DNA binding protein 5 (CHD5) acts as a tumor suppressor in various types of cancer and belongs to CHD protein family. However, no prognostic role for CHD5 has yet been indicated in colorectal cancer. Therefore, the ai…
View article: Plastic wound protectors decreased surgical site infections following laparoscopic-assisted colectomy for colorectal cancer
Plastic wound protectors decreased surgical site infections following laparoscopic-assisted colectomy for colorectal cancer Open
Laparoscopic surgery is widespread and safe for the management of patients with colorectal cancer (CRC). Although the use of standard surgical techniques can prevent perioperative wound infections, surgical site infections (SSIs) remain an…
View article: The role of MRP1 in the multidrug resistance of colorectal cancer
The role of MRP1 in the multidrug resistance of colorectal cancer Open
The role of multidrug resistance associated protein 1 (MRP1) in the multidrug resistance (MDR) of colorectal cancer (CRC) remains unclear. The present study aimed to investigate the effect of MRP1 in MDR CRC and its therapeutic potential f…
View article: MicroRNA-187 inhibits tumor growth and invasion by directly targeting CD276 in colorectal cancer
MicroRNA-187 inhibits tumor growth and invasion by directly targeting CD276 in colorectal cancer Open
Aberrantly expressed microRNAs contribute to the initiation and progression of human cancers. However, the underlying functions of microRNA-187 (miR-187) in colorectal cancer (CRC) remain largely unexplored. Here, we demonstrated that miR-…
View article: The clinical impact of ICOS signal in colorectal cancer patients
The clinical impact of ICOS signal in colorectal cancer patients Open
The inducible T-cell co-stimulator (ICOS) belongs to the B7-CD28 immunoglobulin superfamily, which is currently the subject of intense study due to great successes gained in treatment of different malignancies by disrupting their family me…
View article: miR-193b directly targets STMN1 and inhibits the malignant phenotype in colorectal cancer.
miR-193b directly targets STMN1 and inhibits the malignant phenotype in colorectal cancer. Open
Accumulating evidence suggests that aberrantly expressed microRNAs (miRNAs) contribute to the initiation and progression of human cancers. However, the underlying function of miR-193b in colorectal cancer (CRC) remains largely unexplored. …
View article: Increased expression of Rab5A predicts metastasis and poor prognosis in colorectal cancer patients.
Increased expression of Rab5A predicts metastasis and poor prognosis in colorectal cancer patients. Open
Rab5A is reported to correlate with cancer development and progression. The purpose of this study is to explore the association between Rab5A expression and the clinical characteristics of colorectal cancer (CRC). Data containing three ind…
View article: Up-regulated CKS2 promotes tumor progression and predicts a poor prognosis in human colorectal cancer.
Up-regulated CKS2 promotes tumor progression and predicts a poor prognosis in human colorectal cancer. Open
Cyclin-dependent kinases regulatory subunit 2 (CKS2) is a cyclin-dependent kinase-interacting protein, which is essential for cell cycle regulation. Elevated expression of CKS2 has been demonstrated in multiple types of human malignancies.…
View article: ATAD2 Overexpression Identifies Colorectal Cancer Patients with Poor Prognosis and Drives Proliferation of Cancer Cells
ATAD2 Overexpression Identifies Colorectal Cancer Patients with Poor Prognosis and Drives Proliferation of Cancer Cells Open
ATPase family AAA domain-containing 2 (ATAD2) has been identified as a critical modulator involved in cell proliferation and invasion. The purpose of this study was to explore the expression of ATAD2 in CRC tissues as well as its relations…