Shaolei Li
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View article: The role of dynamic monitoring of plasma cell-free DNA methylation in predicting pathological response in resectable stage IIB-IIIB non-small cell lung cancer: biomarker analyses from a prospective phase II trial
The role of dynamic monitoring of plasma cell-free DNA methylation in predicting pathological response in resectable stage IIB-IIIB non-small cell lung cancer: biomarker analyses from a prospective phase II trial Open
View article: Synthesis, anticancer activity and molecular modeling of new NSAIDs-Ebselen derivatives as potential TrxR1 inhibitor
Synthesis, anticancer activity and molecular modeling of new NSAIDs-Ebselen derivatives as potential TrxR1 inhibitor Open
View article: The Effects of Cardiovascular Health Behaviors and Risk Factors on Brachial-Ankle Pulse Wave Velocity in Middle-Aged Men： in Southeastern China
The Effects of Cardiovascular Health Behaviors and Risk Factors on Brachial-Ankle Pulse Wave Velocity in Middle-Aged Men： in Southeastern China Open
Cardiovascular diseases (CVD) were the leading cause of global mortality. We conducted a across sectional study and to investigate the association between cardiovascular health behaviors and risk factors with brachial-ankle pulse wave velo…
View article: Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor ratio > 0.5
Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor ratio > 0.5 Open
Background Precisely predicting lymph node metastasis (LNM) status is critical for the treatment of early non-small5-cell lung cancer (NSCLC). In this study, we developed a LNM prediction tool for peripheral NSCLC with a tumor diameter ≤ 2…
View article: The effects and predictive values of novel anthropometric parameters on uric acid levels and hyperuricemia in adults
The effects and predictive values of novel anthropometric parameters on uric acid levels and hyperuricemia in adults Open
View article: Efficacy of neoadjuvant toripalimab plus chemotherapy and the role of dynamic monitoring of plasma cell-free DNA methylation in predicting pathological response in resectable stage IIB-IIIB non-small cell lung cancer (RENAISSANCE study): a prospective phase II trial
Efficacy of neoadjuvant toripalimab plus chemotherapy and the role of dynamic monitoring of plasma cell-free DNA methylation in predicting pathological response in resectable stage IIB-IIIB non-small cell lung cancer (RENAISSANCE study): a prospective phase II trial Open
Introduction: Neoadjuvant chemoimmunotherapy does not benefit all non-small cell lung cancer (NSCLC) patients, and reliable biomarkers are urgently needed. We conducted this prospective phase II trial of neoadjuvant chemoimmunotherapy to e…
View article: MRI-based habitat imaging in cancer treatment: current technology, applications, and challenges
MRI-based habitat imaging in cancer treatment: current technology, applications, and challenges Open
Extensive efforts have been dedicated to exploring the impact of tumor heterogeneity on cancer treatment at both histological and genetic levels. To accurately measure intra-tumoral heterogeneity, a non-invasive imaging technique, known as…
View article: Comparison of the Long-term Survival Outcome of Surgery versus Stereotactic Body Radiation Therapy as Initial Local Treatment for Pulmonary Oligometastases from Colorectal Cancer: A Propensity Score Analysis
Comparison of the Long-term Survival Outcome of Surgery versus Stereotactic Body Radiation Therapy as Initial Local Treatment for Pulmonary Oligometastases from Colorectal Cancer: A Propensity Score Analysis Open
Notwithstanding the significant differences in FFIP and PFS between surgery and SBRT, the long-term survival of patients with CRC pulmonary oligometastases did not depend on the initial choice of the local treatment approach.
View article: MRI-based Tumor Habitat Analysis for Treatment Evaluation of Radiotherapy on Esophageal Cancer
MRI-based Tumor Habitat Analysis for Treatment Evaluation of Radiotherapy on Esophageal Cancer Open
Introduction: We aim to evaluate the performance of pre-treatment MRI-based habitat imaging to segment tumor micro-environment and its potential to identify patients with esophageal cancer who can achieve pathological complete response (pC…
View article: Efficacy of a smartphone application assisting home-based rehabilitation and symptom management for patients with lung cancer undergoing video-assisted thoracoscopic lobectomy: a prospective, single-blinded, randomised control trial (POPPER study)
Efficacy of a smartphone application assisting home-based rehabilitation and symptom management for patients with lung cancer undergoing video-assisted thoracoscopic lobectomy: a prospective, single-blinded, randomised control trial (POPPER study) Open
Background: Video-assisted thoracoscopic (VATS) lobectomy can affect patients’ pulmonary function and quality of life significantly. No optimal protocol combining patient-reported outcome-based symptom management and postdischarge rehabili…
View article: Effects of novel anthropometric parameters on uric acid levels and hyperuricemia in adults and their predictive value: a cross-sectional study in Su-Wuxi-Chang area, Jiangsu, China
Effects of novel anthropometric parameters on uric acid levels and hyperuricemia in adults and their predictive value: a cross-sectional study in Su-Wuxi-Chang area, Jiangsu, China Open
Novel anthropometric indices are more closely related to metabolic abnormalities than traditional anthropometric indices. Fewer studies have been conducted based on the relationship between novel anthropometric indicators and hyperuricemia…
View article: Beneficial implications of adjuvant chemotherapy for stage IB lung adenocarcinoma exhibiting elevated SUVmax in FDG-PET/CT: a retrospective study from a single center
Beneficial implications of adjuvant chemotherapy for stage IB lung adenocarcinoma exhibiting elevated SUVmax in FDG-PET/CT: a retrospective study from a single center Open
Background Controversy surrounds the efficacy of adjuvant chemotherapy (ACT) in the treatment of stage I lung adenocarcinoma (LUAD). The objective of this study was to examine the impact of the maximum standardized uptake value (SUVmax) as…
View article: Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression Open
Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar) histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but the molecular features associated with different subtype…
View article: Synthesis, cytotoxicity, antioxidant activity and molecular modeling of new NSAIDs-EBS derivatives
Synthesis, cytotoxicity, antioxidant activity and molecular modeling of new NSAIDs-EBS derivatives Open
View article: Association of early immune-related adverse events with treatment efficacy of neoadjuvant Toripalimab in resectable advanced non-small cell lung cancer
Association of early immune-related adverse events with treatment efficacy of neoadjuvant Toripalimab in resectable advanced non-small cell lung cancer Open
Background Neoadjuvant immunotherapy with anti-PD-1 was proved promising in resectable non-small cell lung cancer (NSCLC). Immune-related adverse events (irAEs) have been preliminarily implicated their association with treatment efficacy. …
View article: Osimertinib as neoadjuvant therapy in patients with EGFR-mutant resectable stage II-IIIB lung adenocarcinoma (NEOS): A multicenter, single-arm, open-label phase 2b trial
Osimertinib as neoadjuvant therapy in patients with EGFR-mutant resectable stage II-IIIB lung adenocarcinoma (NEOS): A multicenter, single-arm, open-label phase 2b trial Open
The third-generation EGFR TKI osimertinib, with satisfying efficacy and acceptable safety profile, could be a promising neoadjuvant therapy in patients with resectable EGFR-mutant NSCLC.
View article: Efficacy and Safety of a Smartphone Application Assisting Home-Based Rehabilitation and Symptom Management for Patients with Lung Cancer Undergoing Video-Assisted Thoracoscopic Lobectomy: A Prospective, Single-Blinded, Randomised Control Trial (POPPER Study)
Efficacy and Safety of a Smartphone Application Assisting Home-Based Rehabilitation and Symptom Management for Patients with Lung Cancer Undergoing Video-Assisted Thoracoscopic Lobectomy: A Prospective, Single-Blinded, Randomised Control Trial (POPPER Study) Open
View article: Accuracy and efficiency of an artificial intelligence-based pulmonary broncho-vascular three-dimensional reconstruction system supporting thoracic surgery: retrospective and prospective validation study
Accuracy and efficiency of an artificial intelligence-based pulmonary broncho-vascular three-dimensional reconstruction system supporting thoracic surgery: retrospective and prospective validation study Open
View article: Single-cell RNA sequencing reveals the cellular and molecular changes that contribute to the progression of lung adenocarcinoma
Single-cell RNA sequencing reveals the cellular and molecular changes that contribute to the progression of lung adenocarcinoma Open
Pure ground glass nodules (GGNs) and solid nodules (SNs) represent early and relatively late stages of lung adenocarcinoma (LUAD) in radiology, respectively. The cellular and molecular characteristics of pure GGNs and SNs have not been com…
View article: New Organoselenium (NSAIDs-Selenourea and Isoselenocyanate) Derivatives as Potential Antiproliferative Agents: Synthesis, Biological Evaluation and in Silico Calculations
New Organoselenium (NSAIDs-Selenourea and Isoselenocyanate) Derivatives as Potential Antiproliferative Agents: Synthesis, Biological Evaluation and in Silico Calculations Open
In this study, we report on the synthesis of new organoselenium derivatives, including nonsteroidal anti-inflammatory drugs (NSAIDs) scaffolds and Se functionalities (isoselenocyanate and selenourea), which were evaluated against four type…
View article: CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma
CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma Open
View article: Comprehensive genomic analysis of primary malignant melanoma of the esophagus reveals similar genetic patterns compared with epithelium-associated melanomas
Comprehensive genomic analysis of primary malignant melanoma of the esophagus reveals similar genetic patterns compared with epithelium-associated melanomas Open
View article: Using Natural Language Processing and Machine Learning to Preoperatively Predict Lymph Node Metastasis for Non–Small Cell Lung Cancer With Electronic Medical Records: Development and Validation Study
Using Natural Language Processing and Machine Learning to Preoperatively Predict Lymph Node Metastasis for Non–Small Cell Lung Cancer With Electronic Medical Records: Development and Validation Study Open
Background Lymph node metastasis (LNM) is critical for treatment decision making of patients with resectable non–small cell lung cancer, but it is difficult to precisely diagnose preoperatively. Electronic medical records (EMRs) contain a …
View article: circ_0000567/miR-421/<i>TMEM100</i> Axis Promotes the Migration and Invasion of Lung Adenocarcinoma and Is Associated with Prognosis
circ_0000567/miR-421/<i>TMEM100</i> Axis Promotes the Migration and Invasion of Lung Adenocarcinoma and Is Associated with Prognosis Open
Purpose: Due to the high metastatic ability and poor prognosis of lung adenocarcinoma (LUAD), we identified novel non-coding RNAs, which constitute approximately 60% of human transcripts, as prognostic biomarkers and potential thera…
View article: Accuracy and Efficiency of a Novel Artificial Intelligence-Based Pulmonary Broncho-Vascular Three-Dimensional Reconstruction System Supporting Thoracic Surgery: Retrospective and Prospective Validation Study
Accuracy and Efficiency of a Novel Artificial Intelligence-Based Pulmonary Broncho-Vascular Three-Dimensional Reconstruction System Supporting Thoracic Surgery: Retrospective and Prospective Validation Study Open
View article: Hsa_circ_0007312 Promotes Third-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance through Pyroptosis and Apoptosis via the MiR-764/MAPK1 Axis in Lung Adenocarcinoma Cells
Hsa_circ_0007312 Promotes Third-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance through Pyroptosis and Apoptosis via the MiR-764/MAPK1 Axis in Lung Adenocarcinoma Cells Open
Purposes: Osimertinib is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) used for patients with gefitinib (first-generation EGFR-TKI) resistance, but osimertinib resistance inevitably occurs.…
View article: The efficacy and safety of cabazitaxel in patients with metastatic castration-resistant prostate cancer: a system review and meta analysis of randomized controlled trials
The efficacy and safety of cabazitaxel in patients with metastatic castration-resistant prostate cancer: a system review and meta analysis of randomized controlled trials Open
The efficacy and safety of cabazitaxel in patients with metastatic castration
View article: Aneuploid Circulating Tumor Cells as a Predictor of Response to Neoadjuvant Chemotherapy in Non-Small Cell Lung Cancer
Aneuploid Circulating Tumor Cells as a Predictor of Response to Neoadjuvant Chemotherapy in Non-Small Cell Lung Cancer Open
The correlations of aneuploid CTCs with both radiological and pathological responses in patients with NSCLC who received NAC were summarized, and the findings indicate that enumerating and karyotyping aneuploid CTCs can serve as a surrogat…
View article: A novel deep learning approach to extract Chinese clinical entities for lung cancer screening and staging
A novel deep learning approach to extract Chinese clinical entities for lung cancer screening and staging Open
Background Computed tomography (CT) reports record a large volume of valuable information about patients’ conditions and the interpretations of radiology images from radiologists, which can be used for clinical decision-making and further …
View article: Automatic Extraction of Lung Cancer Staging Information From Computed Tomography Reports: Deep Learning Approach
Automatic Extraction of Lung Cancer Staging Information From Computed Tomography Reports: Deep Learning Approach Open
Background Lung cancer is the leading cause of cancer deaths worldwide. Clinical staging of lung cancer plays a crucial role in making treatment decisions and evaluating prognosis. However, in clinical practice, approximately one-half of t…