Shaolong He
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View article: Study on the properties and <i>in vitro</i> transdermal delivery and cytotoxicity of drug-active ionic liquids with matrine as the cation
Study on the properties and <i>in vitro</i> transdermal delivery and cytotoxicity of drug-active ionic liquids with matrine as the cation Open
Combining ionic liquids with active pharmaceutical ingredients (API-ILs) is an ideal strategy to improve the biopharmaceutical properties of APIs while preserving their efficacy.
View article: Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery
Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery Open
Many drug candidates are poorly water-soluble. Microenvironmental pH (pHM) modification in buccal/sublingual dosage forms has attracted increasing interest as a promising pharmaceutical strategy to enhance the oral mucosal absorption of dr…
View article: In vitro and ex vivo evaluation of bilayered effervescent microenvironmental pH modifying buccal films with saquinavir
In vitro and ex vivo evaluation of bilayered effervescent microenvironmental pH modifying buccal films with saquinavir Open
View article: <i>In Vitro</i> and <i>Ex Vivo</i> Evaluation of Bi-Layered Effervescent Microenvironmental PH Modifying Buccal Films with Saquinavir
<i>In Vitro</i> and <i>Ex Vivo</i> Evaluation of Bi-Layered Effervescent Microenvironmental PH Modifying Buccal Films with Saquinavir Open
View article: Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir
Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir Open
Oromucosal patches for drug delivery allow fast onset of action and ability to circumvent hepatic first pass metabolism of drugs. While conventional fabrication methods such as solvent casting or hot melt extrusion are ideal for scalable p…
View article: Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films
Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films Open
Buccal films containing a pH modifying excipient may be able to increase bioavailability of drugs with pH-dependent solubility such as saquinavir. Access to suitable in vitro drug release testing methods may facilitate buccal formulation d…
View article: Hepatic targeting of glycyrrhetinic acid <i>via</i> nanomicelles based on stearic acid-modified fenugreek gum
Hepatic targeting of glycyrrhetinic acid <i>via</i> nanomicelles based on stearic acid-modified fenugreek gum Open
This study aimed to increase the solubility of glycyrrhetinic acid (GA) in water and enhance its liver-targeting ability using self-assembling nanomicelles (NMs) based on stearic acid-modified fenugreek gum (FG-C18). The GA/FG-C…
View article: Synthesis and evaluation of hydrophobically modified fenugreek gum for potential hepatic drug delivery
Synthesis and evaluation of hydrophobically modified fenugreek gum for potential hepatic drug delivery Open
The objective of this study was to hydrophobically modify fenugreek gum (FG) and to further evaluate the potential application of the obtained derivative in liver-targeted drug delivery system. Stearic acid (C18) was conjugated …
View article: Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting
Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting Open
Silymarin has been widely used as a hepatoprotective drug in the treatment of various liver diseases, yet its effectiveness is affected by its poor water solubility and low bioavailability after oral administration, and there is a need for…
View article: Synthesis, self-assembly, and <i>in vitro</i> toxicity of fatty acids-modified <i>Bletilla striata</i> polysaccharide
Synthesis, self-assembly, and <i>in vitro</i> toxicity of fatty acids-modified <i>Bletilla striata</i> polysaccharide Open
Hydrophobic modification of Bletilla striata polysaccharide (BSP) was performed by grafting fatty acids to BSP backbone and then characterized on their physicochemical properties. All neutral derivatives were able to self-assemble into sph…