Shaomin Hu
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View article: Clinicopathologic Features of Untreated Colorectal Cancer with Acellular Mucin–Only Lymph Nodes
Clinicopathologic Features of Untreated Colorectal Cancer with Acellular Mucin–Only Lymph Nodes Open
Lymph nodes (LNs) containing only acellular mucin are considered negative for metastasis in treated colorectal cancers (CRCs). However, no data exist on how to stage these LNs in untreated CRCs. We collected 63 untreated CRC cases with LNs…
View article: Oral and intratumoral microbiota influence tumor immunity and patient survival
Oral and intratumoral microbiota influence tumor immunity and patient survival Open
Background The aim of this study was to analyze the changes in the oral microbiota of patients with oral squamous cell carcinoma (OSCC) compared to healthy controls and the effect of intratumoral microorganisms on the host immune microenvi…
View article: Extraskeletal Ewing Sarcoma of the Gastrointestinal and Hepatobiliary Tract
Extraskeletal Ewing Sarcoma of the Gastrointestinal and Hepatobiliary Tract Open
Ewing sarcoma (ES) is an uncommon mesenchymal neoplasm that typically develops as a bone mass, although up to 30% arise in extraskeletal sites. ES of the gastrointestinal (GI) and hepatobiliary tract is rare and may be misdiagnosed as othe…
View article: Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis
Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis Open
Objective Intestinal fibrosis is considered an inevitable consequence of chronic IBD, leading to stricture formation and need for surgery. During the process of fibrogenesis, extracellular matrix (ECM) components critically regulate the fu…
View article: OP22 Topical Sphingosine-1-Phosphate (S1P) Receptor 1 Modulation Regulates Gut Angiogenesis in Inflammatory Bowel Diseases
OP22 Topical Sphingosine-1-Phosphate (S1P) Receptor 1 Modulation Regulates Gut Angiogenesis in Inflammatory Bowel Diseases Open
Background S1P receptor (S1PR)1/5 modulators have been tested successfully in clinical development programs in ulcerative colitis (UC), leading to their FDA approval. They are believed to act through lymphocyte redistribution in peripheral…
View article: Stricturing Crohn’s disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions
Stricturing Crohn’s disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions Open
Background Fibroblasts play a key role in stricture formation in Crohn’s disease (CD) but understanding it’s pathogenesis requires a systems-level investigation to uncover new treatment targets. We studied full thickness CD tissues to char…
View article: DOP32 Crohn’s disease stricture matrisome analysis reveals the anti-fibrotic activity of milk-fat globule-epidermal growth factor 8 (MFGE8)
DOP32 Crohn’s disease stricture matrisome analysis reveals the anti-fibrotic activity of milk-fat globule-epidermal growth factor 8 (MFGE8) Open
Background Intestinal fibrosis is considered an inevitable consequence of chronic inflammatory bowel disease (IBD), leading to stricture formation and need for surgery. During the process of fibrogenesis, extracellular matrix (ECM) compone…
View article: A Low rectal GIST
A Low rectal GIST Open
A man in his 70s presented with narrowing of his stool calibre and a palpable mass on rectal examination. Colonoscopy revealed a submucosal bulge without a mucosal lesion. CT and MRI demonstrated an 8×5.4×7 cm mass in lower rectum. Biopsy …
View article: Adult colo-colonic intussusception
Adult colo-colonic intussusception Open
View article: 18: Effect of clinical initiation of elexacaftor/tezacaftor/ivacaftor on glucose homeostasis in patients with cystic fibrosis
18: Effect of clinical initiation of elexacaftor/tezacaftor/ivacaftor on glucose homeostasis in patients with cystic fibrosis Open
View article: Coordinated co-migration of CCR10+ antibody-producing B cells with helper T cells for colonic homeostatic regulation
Coordinated co-migration of CCR10+ antibody-producing B cells with helper T cells for colonic homeostatic regulation Open
View article: Preferential Perinatal Development of Skin-Homing NK1.1+ Innate Lymphoid Cells for Regulation of Cutaneous Microbiota Colonization
Preferential Perinatal Development of Skin-Homing NK1.1+ Innate Lymphoid Cells for Regulation of Cutaneous Microbiota Colonization Open
View article: Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases
Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases Open
View article: Abstracts from USCAP 2019: Liver Pathology (1509-1580)
Abstracts from USCAP 2019: Liver Pathology (1509-1580) Open
View article: Training the Next Generation of Pathologists: A Novel Residency Program Curriculum at Montefiore Medical Center/Albert Einstein College of Medicine
Training the Next Generation of Pathologists: A Novel Residency Program Curriculum at Montefiore Medical Center/Albert Einstein College of Medicine Open
View article: Increased Incidence of Acquired Protein S Deficiency in Sickle Cell Disease
Increased Incidence of Acquired Protein S Deficiency in Sickle Cell Disease Open
Patients with sickle cell disease (SCD) show various manifestations of arterial and venous thrombosis, especially around sickle cell crises. There are numerous pathophysiologic factors that could explain hypercoagulability in SCD (vessel i…
View article: Diffuse large B-cell lymphoma with strong aberrant expression of CD31
Diffuse large B-cell lymphoma with strong aberrant expression of CD31 Open
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A 49-year-old man presented with an 8.8 × 6.5 cm, left infraclavicular subpectoral mass. A biopsy showed predominantly spindle-ish cells (panels A-B, hematoxylin and eosin stain; original magnifications shown on pictures) an…
View article: Educational Case: Immune-Related Disorders of the Bowel
Educational Case: Immune-Related Disorders of the Bowel Open
View article: Are the uterine serous carcinomas underdiagnosed? Histomorphologic and immunohistochemical correlates and clinical follow up in high-grade endometrial carcinomas initially diagnosed as high-grade endometrioid carcinoma
Are the uterine serous carcinomas underdiagnosed? Histomorphologic and immunohistochemical correlates and clinical follow up in high-grade endometrial carcinomas initially diagnosed as high-grade endometrioid carcinoma Open
View article: Frequency Split Elimination of Fused Silica Cylindrical Resonators by Chemical Etching
Frequency Split Elimination of Fused Silica Cylindrical Resonators by Chemical Etching Open
This article describes a new trimming method for eliminating frequency split of an imperfect fused silica cylindrical resonator. First, the effect of the 4th harmonic deviation on the formation of frequency split is analyzed. Then, a chemi…
View article: Selective programming of CCR10+ innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation
Selective programming of CCR10+ innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation Open
View article: Regulation of intestinal IgA responses
Regulation of intestinal IgA responses Open