Shaoning Jiang
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View article: A Comparison of Novel Serum Markers of Liver Health in Adolescents With Metabolic Dysfunction‐Associated Steatotic Liver Disease
A Comparison of Novel Serum Markers of Liver Health in Adolescents With Metabolic Dysfunction‐Associated Steatotic Liver Disease Open
Several non‐invasive biomarkers for paediatric metabolic dysfunction‐associated steatotic liver disease (MASLD) have been reported, but no prior studies directly compared multiple protein or microRNA (miRNA) markers of liver health in adol…
View article: Adipose Tissue-Derived Extracellular Vesicle MicroRNAs: Diagnostic Biomarkers for the Pathophysiology Associated with Obesity
Adipose Tissue-Derived Extracellular Vesicle MicroRNAs: Diagnostic Biomarkers for the Pathophysiology Associated with Obesity Open
Obesity is a global health problem that increases the risk of type 2 diabetes, cardiovascular diseases, fatty liver disease, and cancer. The pathological outcomes of obesity and the responses to weight loss interventions vary significantly…
View article: AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells
AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells Open
Adverse intrauterine environments can cause persistent changes in epigenetic profiles of stem cells, increasing susceptibility of the offspring to developing metabolic diseases later in life. Effective approaches to restore the epigenetic …
View article: miR-130b/301b is a Negative Regulator of Beige Adipogenesis and Energy Metabolism in vitro and in vivo
miR-130b/301b is a Negative Regulator of Beige Adipogenesis and Energy Metabolism in vitro and in vivo Open
Thermogenic brown or beige adipocytes dissipate energy in the form of heat and thereby counteract obesity and related metabolic complications. The microRNA cluster, miR-130b/301b, is highly expressed in adipose tissues and has been implica…
View article: miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo
miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo Open
Thermogenic brown or beige adipocytes dissipate energy in the form of heat and thereby counteract obesity and related metabolic complications. The miRNA cluster miR-130b/301b is highly expressed in adipose tissues and has been implicated i…
View article: miR-130b/301b is a Negative Regulator of Beige Adipogenesis and Energy Metabolism in vitro and in vivo
miR-130b/301b is a Negative Regulator of Beige Adipogenesis and Energy Metabolism in vitro and in vivo Open
Thermogenic brown or beige adipocytes dissipate energy in the form of heat and thereby counteract obesity and related metabolic complications. The microRNA cluster, miR-130b/301b, is highly expressed in adipose tissues and has been implica…
View article: AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections
AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections Open
Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to bacterial infections. AMPK and Parkin ubiquitin ligase are known to regulate mitochondrial quality control mitophagy that prevents unwanted inflamm…
View article: Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis Open
Background Diabetes during pregnancy affects placental mitochondrial content and function, which has the potential to impact fetal development and the long-term health of offspring. Resistin is a peptide hormone originally discovered in mi…
View article: Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis Open
Background: Diabetes during pregnancy affects placental mitochondrial content and function, which has the potential to impact fetal development and the long-term health of offspring. Resistin is a peptide hormone originally discovered in m…
View article: Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes
Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes Open
View article: Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis Open
Background Diabetes during pregnancy affects placental mitochondrial content and function, which can impact fetal development and the long-term health of offspring. Resistin is a peptide hormone originally discovered in mice as an adipocyt…
View article: Macrophage‐Derived microRNA‐155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator‐Activated Receptor Gamma
Macrophage‐Derived microRNA‐155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator‐Activated Receptor Gamma Open
Objective This study aimed to investigate cellular sources of microRNAs (miRNA) within adipose tissue and the impact of obesity on miRNA expression, as well as to examine targets of miRNAs. Methods miRNA expression by quantitative polymera…
View article: Supplementary Material for: Novel Model Predicts Diabetic Nephropathy in Type 2 Diabetes
Supplementary Material for: Novel Model Predicts Diabetic Nephropathy in Type 2 Diabetes Open
Background: Clinical indicators for accurately distinguishing diabetic nephropathy (DN) from non-diabetic renal disease in type 2 diabetes (T2D) are lacking. This study aimed to develop and validate a nomogram for predicting …
View article: Author Correction: Metformin reverses established lung fibrosis in a bleomycin model
Author Correction: Metformin reverses established lung fibrosis in a bleomycin model Open
View article: Metformin reverses established lung fibrosis in a bleomycin model
Metformin reverses established lung fibrosis in a bleomycin model Open
View article: Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis
Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis Open
View article: Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA
Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA Open
We aimed to identify miRNAs whose expression levels in fetal tissues are altered by exposure to a diabetic milieu and elucidate the impact on target protein expression. Gestational diabetes mellitus (GDM) affects both immediate and future …
View article: Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase
Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase Open
View article: AMP-Activated Protein Kinase and Glycogen Synthase Kinase 3β Modulate the Severity of Sepsis-induced Lung injury
AMP-Activated Protein Kinase and Glycogen Synthase Kinase 3β Modulate the Severity of Sepsis-induced Lung injury Open
Alterations in metabolic and bioenergetic homeostasis contribute to sepsis-mediated organ injury. However, how AMP-activated protein kinase (AMPK), a major sensor and regulator of energy expenditure and production, affects development of o…