Shaopeng Pei
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View article: Osteocyte mechanosensing: interstitial fluid flow, cellular response, and turnover of pericellular matrix
Osteocyte mechanosensing: interstitial fluid flow, cellular response, and turnover of pericellular matrix Open
Bone is a “smart” living tissue that adapts to its mechanical environment. Yet, the mechanisms by which bone senses and responds to the external mechanical stimuli remain inconclusive. The work presented in this thesis aimed at understandi…
View article: The Association of Maternal Smoking and Drinking Changes During Pregnancy and Postpartum Breastfeeding Pattern and Duration
The Association of Maternal Smoking and Drinking Changes During Pregnancy and Postpartum Breastfeeding Pattern and Duration Open
Objectives: To conduct a secondary data analysis of how changes in smoking and drinking during pregnancy impact status of any breastfeeding and breastfeeding duration in a national cohort. Materials and Methods:…
View article: Osteocytic Pericellular Matrix (PCM): Accelerated Degradation under In Vivo Loading and Unloading Conditions Using a Novel Imaging Approach
Osteocytic Pericellular Matrix (PCM): Accelerated Degradation under In Vivo Loading and Unloading Conditions Using a Novel Imaging Approach Open
The proteoglycan-containing pericellular matrix (PCM) controls both the biophysical and biochemical microenvironment of osteocytes, which are the most abundant cells embedded and dispersed in bones. As a molecular sieve, osteocytic PCMs no…
View article: Activation, development, and attenuation of modeling- and remodeling-based bone formation in adult rats
Activation, development, and attenuation of modeling- and remodeling-based bone formation in adult rats Open
View article: Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer
Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer Open
View article: Maternal bone adaptation to mechanical loading during pregnancy, lactation, and post-weaning recovery
Maternal bone adaptation to mechanical loading during pregnancy, lactation, and post-weaning recovery Open
View article: Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis
Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis Open
View article: Distinct Responses of Modeling- and Remodeling-Based Bone Formation to the Discontinuation of Intermittent Parathyroid Hormone Treatment in Ovariectomized Rats
Distinct Responses of Modeling- and Remodeling-Based Bone Formation to the Discontinuation of Intermittent Parathyroid Hormone Treatment in Ovariectomized Rats Open
Anabolic agents, such as intermittent parathyroid hormone (PTH), exert their treatment efficacy through activation of two distinct bone formation processes, namely, remodeling-based bone formation (RBF, bone formation coupled with prior bo…
View article: Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton
Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton Open
Perlecan/Hspg2, a large monomeric heparan sulfate proteoglycan, is found in the basement membrane and extracellular matrix, where it acts as a matrix scaffold, growth factor depot, and tissue barrier. Perlecan deficiency leads to skeletal …
View article: Perlecan/Hspg2 deficiency impairs bone’s calcium signaling and associated transcriptome in response to mechanical loading
Perlecan/Hspg2 deficiency impairs bone’s calcium signaling and associated transcriptome in response to mechanical loading Open
View article: On the characterization of interstitial fluid flow in the skeletal muscle endomysium
On the characterization of interstitial fluid flow in the skeletal muscle endomysium Open
View article: A multiscale 3D finite element analysis of fluid/solute transport in mechanically loaded bone
A multiscale 3D finite element analysis of fluid/solute transport in mechanically loaded bone Open
The transport of fluid, nutrients, and signaling molecules in the bone lacunar–canalicular system (LCS) is critical for osteocyte survival and function. We have applied the fluorescence recovery after photobleaching (FRAP) approach to quan…