Shiqing Xu
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View article: Convergent Gut Microbiome Adaptation and Pervasive Antibiotic Resistome in Qinghai‒Tibet Plateau Passerines
Convergent Gut Microbiome Adaptation and Pervasive Antibiotic Resistome in Qinghai‒Tibet Plateau Passerines Open
Metagenomic analysis of nonmigratory passerines (Pseudopodoces humilis and Pyrgilauda ruficollis) and their habitats on the Qinghai‒Tibet Plateau revealed convergent adaptations in gut microbial composition and function dominated by Bacill…
View article: Postoperative hepatitis B virus reactivation and its impact on survival in HBV-related hepatocellular carcinoma patients undergoing conversion therapy with interventional therapy combined with tyrosine kinase inhibitors and immune checkpoint inhibitors
Postoperative hepatitis B virus reactivation and its impact on survival in HBV-related hepatocellular carcinoma patients undergoing conversion therapy with interventional therapy combined with tyrosine kinase inhibitors and immune checkpoint inhibitors Open
Objective This study aimed to investigate hepatitis B virus (HBV) reactivation and its impact on postoperative survival in patients with HBV-related hepatocellular carcinoma (HCC) who underwent conversion therapy. The therapeutic regimen c…
View article: Application of collagen in bone regeneration
Application of collagen in bone regeneration Open
At present, there is a significant population of individuals experiencing bone deficiencies caused by injuries, ailments affecting the bones, congenital abnormalities, and cancer. The management of substantial bone defects a significant gl…
View article: The <scp>JNK</scp> signalling pathway gene <i>BmJun</i> is involved in the regulation of egg quality and production in the silkworm, <i>Bombyx mori</i>
The <span>JNK</span> signalling pathway gene <i>BmJun</i> is involved in the regulation of egg quality and production in the silkworm, <i>Bombyx mori</i> Open
The Jun N‐terminal kinase (JNK) signalling pathway has a key role in tissue remodelling during insect metamorphosis by regulating programmed cell death. However, multiple members of the JNK pathway in Lepidoptera remain uncharacterized. In…
View article: β-tcp/collagen composite scaffolds facilitate bone remodeling in vertebral plate fusion
β-tcp/collagen composite scaffolds facilitate bone remodeling in vertebral plate fusion Open
Purpose Beta-tricalcium phosphate (β-TCP) exhibits rapid osteogenesis and poor ductility. To overcome these disadvantages, we selected β-TCP/collagen for this study. Methods β-TCP/collagen and β-TCP were used as experimental and control gr…
View article: Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells
Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells Open
Bruceantinol (BOL), isolated from the dried fruit of the Brucea javanica (L.) Merr., exhibits cytotoxic effects on breast cancer cells. However, the underlying mechanism remains to be fully addressed. In this paper, the MCF-7 and MDA-MB-23…
View article: Effects of Habitual Dietary Change on the Gut Microbiota and Health of Silkworms
Effects of Habitual Dietary Change on the Gut Microbiota and Health of Silkworms Open
Diet plays a crucial role in shaping the gut microbiota and overall health of animals. Traditionally, silkworms are fed fresh mulberry leaves, and artificial diets do not support good health. The aim of this study was to explore the relati…
View article: Dietary Calcium Carbonate Supplementation Prolonged Larval Development by Increasing the Moltinism of the Lepidopteran Model Bombyx Mori
Dietary Calcium Carbonate Supplementation Prolonged Larval Development by Increasing the Moltinism of the Lepidopteran Model Bombyx Mori Open
View article: Mechanism of hyperproteinemia-induced damage to female reproduction in a genetic silkworm model
Mechanism of hyperproteinemia-induced damage to female reproduction in a genetic silkworm model Open
View article: Inhibition of Expression of the Circadian Clock Gene Cryptochrome 1 Causes Abnormal Glucometabolic and Cell Growth in Bombyx mori Cells
Inhibition of Expression of the Circadian Clock Gene Cryptochrome 1 Causes Abnormal Glucometabolic and Cell Growth in Bombyx mori Cells Open
Cryptochrome is the earliest discovered photoreceptor protein in organisms. However, the effect of CRY (BmCRY), the clock protein in Bombyx mori, on the body or cell metabolism remains unclear. In this study, we continuously interfered wit…
View article: Sericin Ser3 Ectopic Expressed in Posterior Silk Gland Affects Hemolymph Immune Melanization Response via Reducing Melanin Synthesis in Silkworm
Sericin Ser3 Ectopic Expressed in Posterior Silk Gland Affects Hemolymph Immune Melanization Response via Reducing Melanin Synthesis in Silkworm Open
The transgenesis of silkworms is an important way to innovate genetic resources and silk function. However, the silk-gland (SG) of transgenic silkworms, which is the most concerned target tissue of sericulture, often suffers from low vital…
View article: The LIM Domain Protein BmFHL2 Inhibits Egg Production in Female Silkworm, Bombyx mori
The LIM Domain Protein BmFHL2 Inhibits Egg Production in Female Silkworm, Bombyx mori Open
The female Bombyx mori accumulates a large amount of egg proteins, mainly Vg and 30K, during egg formation to provide nutrition for embryo development. The synthesis and transport of Vg have been extensively studied, particularly the regul…
View article: Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm
Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm Open
View article: Combined analysis of silk synthesis and hemolymph amino acid metabolism reveal key roles for glycine in increasing silkworm silk yields
Combined analysis of silk synthesis and hemolymph amino acid metabolism reveal key roles for glycine in increasing silkworm silk yields Open
Rearing silkworms (Bombyx mori) using formula feed has revolutionized traditional mulberry feed strategies. However, low silk production efficiencies persist and have caused bottlenecks, hindering the industrial application of formula feed…
View article: Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm
Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm Open
Bombyx mori silk is a super-long natural protein fiber with a unique structure and excellent performance. Innovative silk structures with high performance are in great demand, thus resulting in an industrial bottleneck. Herein, a transgeni…
View article: Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model
Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model Open
Hyperproteinemia is a metabolic disorder associated with increased plasma protein concentration (PPC) and is often clinically complicated by malignant diseases or severe infections. At present, however, research on the molecular mechanism …
View article: Circadian Clock Gene Period Contributes to Diapause via GABAeric-Diapause Hormone Pathway in Bombyx mori
Circadian Clock Gene Period Contributes to Diapause via GABAeric-Diapause Hormone Pathway in Bombyx mori Open
Diapause is a developmental transition in insects based on seasonal adaptation to adversity; it is regulated by a circadian clock system and the endocrine system. However, the molecular node and its mechanism underlying the effects of thes…
View article: Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model
Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model Open
Hyperproteinemia is a metabolic disorder associated with increased plasma protein concentration (PPC). It is often clinically complicated by malignant diseases or severe infections. Research on the molecular mechanism of High PPC (HPPC) is…
View article: Influence of Hyperproteinemia on Insect Innate Immune Function of the Circulatory System in Bombyx mori
Influence of Hyperproteinemia on Insect Innate Immune Function of the Circulatory System in Bombyx mori Open
Metabolic disorders of the circulatory system of animals (e.g., hyperglycemia and hyperlipidemia) can significantly affect immune function; however, since there is currently no reliable animal model for hyperproteinemia, its effects on imm…
View article: Inhibition of Period Gene Expression Causes Repression of Cell Cycle Progression and Cell Growth in the Bombyx mori Cells
Inhibition of Period Gene Expression Causes Repression of Cell Cycle Progression and Cell Growth in the Bombyx mori Cells Open
Circadian clock system disorders can lead to uncontrolled cell proliferation, but the molecular mechanism remains unknown. We used a Bombyx mori animal model of single Period gene (BmPer) expression to investigate this…
View article: Influence of hyperproteinemia on reproductive development in an invertebrate model
Influence of hyperproteinemia on reproductive development in an invertebrate model Open
Hyperproteinemia is a severe metabolic disease characterized by abnormally elevated plasma protein concentrations (PPC). However, there is currently no reliable animal model for PPC, and the pathological mechanism of hyperproteinemia thus …
View article: Induced Hyperproteinemia and Its Effects on the Remodeling of Fat Bodies in Silkworm, Bombyx mori
Induced Hyperproteinemia and Its Effects on the Remodeling of Fat Bodies in Silkworm, Bombyx mori Open
Hyperproteinemia, which is characterized by an abnormally elevated plasma protein concentration (PPC), is a high-mortality, metabolic complication associated with severe liver and kidney disease. It is difficult to clinically distinguish t…
View article: Differences in gut microbiota between silkworms (<i>Bombyx mori</i>) reared on fresh mulberry (<i>Morus alba</i>var. multicaulis) leaves or an artificial diet
Differences in gut microbiota between silkworms (<i>Bombyx mori</i>) reared on fresh mulberry (<i>Morus alba</i>var. multicaulis) leaves or an artificial diet Open
Artificial diets for silkworms have many potential applications and they are important in sericulture.
View article: Metabolomics differences between silkworms (Bombyx mori) reared on fresh mulberry (Morus) leaves or artificial diets
Metabolomics differences between silkworms (Bombyx mori) reared on fresh mulberry (Morus) leaves or artificial diets Open
View article: Inhibition of expression of the circadian clock gene Period causes metabolic abnormalities including repression of glycometabolism in Bombyx mori cells
Inhibition of expression of the circadian clock gene Period causes metabolic abnormalities including repression of glycometabolism in Bombyx mori cells Open
Abnormalities in the circadian clock system are known to affect the body’s metabolic functions, though the molecular mechanisms responsible remain uncertain. In this study, we achieved continuous knockdown of B. mori Period (BmPer) gene ex…
View article: Different toxicity of cadmium telluride, silicon, and carbon nanomaterials against hemocytes in silkworm, Bombyx mori
Different toxicity of cadmium telluride, silicon, and carbon nanomaterials against hemocytes in silkworm, Bombyx mori Open
Exposure to CdTe QDs, SiNPs, or C–NCDs exerted different toxic effects on silkworm hemocytesviathe induction of different PCD processes.
View article: Table of Contents
Table of Contents Open
View article: Reproductive toxicity and gender differences induced by cadmium telluride quantum dots in an invertebrate model organism
Reproductive toxicity and gender differences induced by cadmium telluride quantum dots in an invertebrate model organism Open
Sexual glands are key sites affected by nanotoxicity, but there is no sensitive assay for measuring reproductive toxicity in animals. The aim of this study was to investigate the toxic effects of cadmium telluride quantum dots (CdTe-QDs) o…
View article: Targeting and retention enhancement of quantum dots decorated with amino acids in an invertebrate model organism
Targeting and retention enhancement of quantum dots decorated with amino acids in an invertebrate model organism Open
The use of quantum dots (QDs) in biological imaging applications and targeted drug delivery is expected to increase. However, the efficiency of QDs in drug targeting needs to be improved. Here, we show that amino acids linked to CdTe QDs s…
View article: High yield exogenous protein HPL production in the Bombyx mori silk gland provides novel insight into recombinant expression systems
High yield exogenous protein HPL production in the Bombyx mori silk gland provides novel insight into recombinant expression systems Open
The silk gland of Bombyx mori (BmSG) has gained significant attention by dint of superior synthesis and secretion of proteins. However, the application of BmSG bioreactor is still a controversial issue because of low yields of recombinant …