Shaowen Tang
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View article: Efficacy of neoadjuvant pembrolizumab combined with paclitaxel and cisplatin in locally advanced oropharyngeal and hypopharyngeal squamous cell carcinoma: a retrospective study
Efficacy of neoadjuvant pembrolizumab combined with paclitaxel and cisplatin in locally advanced oropharyngeal and hypopharyngeal squamous cell carcinoma: a retrospective study Open
Objective This retrospective study aims to evaluate the efficacy and safety of pembrolizumab combined with paclitaxel and cisplatin (ICI+TP) in the treatment of locally advanced oropharyngeal and hypopharyngeal squamous cell carcinoma (OPH…
View article: The Potential of Telitacicept in Treating Lupus erythematosus panniculitis: A Case Report
The Potential of Telitacicept in Treating Lupus erythematosus panniculitis: A Case Report Open
Lupus erythematosus panniculitis (LEP) is a rare and serious skin lesion associated with systemic lupus erythematosus (SLE). In the past, the management of LEP has followed the treatment guidelines for SLE, which is based on the administra…
View article: HOPX regulates the invasion and migration abilities of hepatocellular carcinoma by targeting SNAIL
HOPX regulates the invasion and migration abilities of hepatocellular carcinoma by targeting SNAIL Open
View article: Noninvasive neuromodulation for disorders of consciousness: an updated systematic review and meta-analysis
Noninvasive neuromodulation for disorders of consciousness: an updated systematic review and meta-analysis Open
Our findings provide evidence that rTMS and TNS showed more positive effects for DoC, while tDCS was no better than sham stimulation. While, due to the small number of patients in the different studies, the small number of studies and pote…
View article: A young patient with atrial fibrillation, renal infarction, and acute cerebellar infarction: aortic coarctation associated with secondary hypertension
A young patient with atrial fibrillation, renal infarction, and acute cerebellar infarction: aortic coarctation associated with secondary hypertension Open
Coarctation of the aorta is characterised by narrowing of the descending aorta and is a rare cause of secondary hypertension in children and young adults. The aortic stenosis lesion is in a special location with severe consequences, and lo…
View article: Cardiac Computed Tomography to Exclude Left Atrial Appendage Thrombus to Guide Electrical Cardioversion for Atrial Arrhythmias — 4-Year Experience From Counties Manukau
Cardiac Computed Tomography to Exclude Left Atrial Appendage Thrombus to Guide Electrical Cardioversion for Atrial Arrhythmias — 4-Year Experience From Counties Manukau Open
View article: Potential common mechanisms between primary Sjögren’s syndrome and Hashimoto’s thyroiditis: a public databases-based study
Potential common mechanisms between primary Sjögren’s syndrome and Hashimoto’s thyroiditis: a public databases-based study Open
Objective Primary Sjögren’s syndrome (pSS) and Hashimoto thyroiditis (HT) can occur in the same patient population, but the mechanism of co-occurrence remains unknown. This study aims to explore the underlying mechanism. Methods We screene…
View article: Downregulation of HOPX promotes the invasion and migration abilities of hepatocellular carcinoma cells through EMT-related transcription factor SNAIL
Downregulation of HOPX promotes the invasion and migration abilities of hepatocellular carcinoma cells through EMT-related transcription factor SNAIL Open
HOPX acts as a tumor suppressor in certain cancers, but the function of HOPX, as well as its mechanism of action in hepatocellular carcinoma (HCC) has not been fully elucidated. In this study, using in vitroand in vivo animal models, the e…
View article: Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity
Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity Open
Background and Aims: The occurrence of anti-tuberculosis drug-induced hepatotoxicity (ATDH) deserves our attention. To explore the role of ATP-binding cassette B6 (ABCB6) polymorphisms and serum levels in the risk of antituberculosis drug-…
View article: WCN25-191 MULTI-OMICS ANALYSIS REVEALS PLASMA BIOMARKER CANDIDATES FOR CALCIFIC UREMIC ARTERIOLOPATHY PATIENTS TREATED WITH HUMAN AMNION-DERIVED MESENCHYMAL STEM CELLS
WCN25-191 MULTI-OMICS ANALYSIS REVEALS PLASMA BIOMARKER CANDIDATES FOR CALCIFIC UREMIC ARTERIOLOPATHY PATIENTS TREATED WITH HUMAN AMNION-DERIVED MESENCHYMAL STEM CELLS Open
View article: P319: Analysis of chromosomal abnormalities associated with early pregnancy loss
P319: Analysis of chromosomal abnormalities associated with early pregnancy loss Open
View article: Baseline Keratin-18 Level And Risk Of Anti-Tuberculosis Drug-Induced Liver Injury: An Individual Matched Case-Control Study
Baseline Keratin-18 Level And Risk Of Anti-Tuberculosis Drug-Induced Liver Injury: An Individual Matched Case-Control Study Open
Anti-tuberculosis drug-induced liver injury (ATLI) presents a grand challenge to the global control of tuberculosis. Serum keratin-18 may have a certain predictive value for the occurrence of liver injury. The purpose of this study is to e…
View article: Roles of NR1I3 and NR1H4 polymorphisms in the susceptibility to antituberculosis drug-induced liver injury in China: a case‒control study
Roles of NR1I3 and NR1H4 polymorphisms in the susceptibility to antituberculosis drug-induced liver injury in China: a case‒control study Open
Objective The pathogenesis of antituberculosis drug-induced liver injury (AT-DILI) remains largely unknown. The current investigation aimed to determine the genetic contribution of the nuclear receptor subfamily 1 Group I member 3 ( NR1I3 …
View article: SGLT2 inhibitors improved clinical outcomes on biliary diseases beyond glycemic control in patients with type 2 diabetes
SGLT2 inhibitors improved clinical outcomes on biliary diseases beyond glycemic control in patients with type 2 diabetes Open
Background & aims Diabetes is known to increase the risk of gallstone disease. This study assesses the impact of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on the incidence of biliary diseases, relative to sulfonylureas, in patient…
View article: Differential diagnosis of congenital ventricular septal defect and atrial septal defect in children using deep learning–based analysis of chest radiographs
Differential diagnosis of congenital ventricular septal defect and atrial septal defect in children using deep learning–based analysis of chest radiographs Open
Deep learning methods such as IncepetionV3 based on chest radiographs in the study showed good performance for differential diagnosis of congenital VSD and ASD, which may be able to assist radiologists in diagnosis, education, and training…
View article: Association of DNA methylation, polymorphism and mRNA level of ALAS1 with antituberculosis drug-induced liver injury
Association of DNA methylation, polymorphism and mRNA level of ALAS1 with antituberculosis drug-induced liver injury Open
Aim: To investigate the association of DNA methylation, genetic polymorphisms and mRNA level of aminolevulinate synthase 1 (ALAS1) with antituberculosis drug-induced liver injury (AT-DILI) risk.Methods: Based on a 1:1 matched…
View article: Impact of low-dose aspirin exposure on obstetrical outcomes: a meta-analysis
Impact of low-dose aspirin exposure on obstetrical outcomes: a meta-analysis Open
To sum up, LDA significantly improved neonatal outcomes in pregnant women at high risk of PE without elevating the risk of placental abruption. These findings support LDA's clinical application in pregnant women, although further research …
View article: Does Proximal Adductor Canal Block Provide Better Analgesic Efficacy than Distal Adductor Canal Block in Patients Undergoing Knee Arthroplasty: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Does Proximal Adductor Canal Block Provide Better Analgesic Efficacy than Distal Adductor Canal Block in Patients Undergoing Knee Arthroplasty: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials Open
To compare the analgesic efficacy and adverse events of proximal versus distal ACB for adults undergoing knee arthroplasty, we searched PubMed, Cochrane, Web of Science, and Embase to identify all eligible randomized controlled trials (RCT…
View article: Multi-Omics Analysis Reveals Prognostic Biomarker Candidates for Calcific Uremic Arteriolopathy Patients Treated with Stem Cells
Multi-Omics Analysis Reveals Prognostic Biomarker Candidates for Calcific Uremic Arteriolopathy Patients Treated with Stem Cells Open
View article: Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis
Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis Open
Background and Aim. UDP-glucuronosyltransferases (UGTs) play an important role in drug metabolism and detoxification by catalyzing the glucuronidation reaction, which is associated with the occurrence of antituberculosis drug-induced liver…
View article: The association of CpG island DNA methylation in the promoter region, genetic polymorphism of ALAS1 with anti-tuberculosis drug-induced liver injury
The association of CpG island DNA methylation in the promoter region, genetic polymorphism of ALAS1 with anti-tuberculosis drug-induced liver injury Open
Anti-tuberculosis drug-induced liver injury (AT-DILI) may be related to the accumulation of hepatotoxin protoporphyrin IX, while aminolevulinate synthase 1 (ALAS1) is the key rate-limiting enzyme. The study aimed to investigate the associa…
View article: Therapeutic effects and mechanism of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient
Therapeutic effects and mechanism of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient Open
Calciphylaxis is a rare cutaneous vascular disease that manifests with intolerable pains, non-healing skin wounds, histologically characterized by calcification, fibrointimal hyperplasia, and microvessel thrombosis. Currently, there are no…
View article: Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease
Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease Open
Blood bone metabolic biomarkers are noninvasive indices for evaluating metabolic bone diseases. We investigated the relationships between blood bone metabolic biomarkers and anemia in chronic kidney disease (CKD) patients and analyzed the …
View article: Therapeutic effects of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient
Therapeutic effects of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient Open
Calciphylaxis is a rare cutaneous vascular disease with clinical manifestations of intolerable pains, non-healing skin wounds, histologically characterized by calcification, fibrointimal hyperplasia, and thrombosis in microvessels. Current…
View article: Supplementary Material for: Insulin Resistance, but Not Obstructive Sleep Apnea Is Associated with Hepatic Steatosis in Chinese Patients with Severe Obesity
Supplementary Material for: Insulin Resistance, but Not Obstructive Sleep Apnea Is Associated with Hepatic Steatosis in Chinese Patients with Severe Obesity Open
Introduction Severe obesity often present with nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea (OSA). Emerging researches suggest OSA plays an important role in NAFLD development and progression while the relationship …
View article: Relationship between blood bone metabolic biomarkers and anemia in CKD patients
Relationship between blood bone metabolic biomarkers and anemia in CKD patients Open
Introduction Blood bone metabolic biomarkers are non-invasive indexes for evaluating renal osteodystrophy (ROD). Here the relationships between blood bone metabolic biomarkers and anemia in chronic kidney disease (CKD) patients are investi…
View article: Incidence and Temporal Trend of Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis
Incidence and Temporal Trend of Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis Open
Background and Aim. Antituberculosis (anti-TB) drug-induced liver injury (ATLI) is a common and serious adverse drug reaction of tuberculosis treatment, and the incidence of ATLI has been reported to vary from 2.0% to 28.0%. This study aim…
View article: Nomogram Model Based on Clinical Risk Factors and Heart Rate Variability for Predicting All-Cause Mortality in Stage 5 CKD Patients
Nomogram Model Based on Clinical Risk Factors and Heart Rate Variability for Predicting All-Cause Mortality in Stage 5 CKD Patients Open
Background: Heart rate variability (HRV), reflecting circadian rhythm of heart rate, is reported to be associated with clinical outcomes in stage 5 chronic kidney disease (CKD5) patients. Whether CKD related factors combined with HRV can i…
View article: Determinants of excessive gestational weight gain: a systematic review and meta-analysis
Determinants of excessive gestational weight gain: a systematic review and meta-analysis Open
View article: Heme Oxygenase-1 and Hemopexin Gene Polymorphisms and the Risk of Anti-Tuberculosis Drug-Induced Hepatotoxicity in China
Heme Oxygenase-1 and Hemopexin Gene Polymorphisms and the Risk of Anti-Tuberculosis Drug-Induced Hepatotoxicity in China Open
Objective: To assess whether the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) might be influenced by heme oxygenase-1 (HMOX1) and hemopexin (HPX) gene polymorphisms. Methods: A dynamic anti-tuber…