Shaoxian Chen
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View article: Developmental arrest of astrocyte lineage in Snai2 deletion mice: implication for the intellectual disability in patients with Waardenburg syndrome
Developmental arrest of astrocyte lineage in Snai2 deletion mice: implication for the intellectual disability in patients with Waardenburg syndrome Open
View article: Multiparametric MRI-based radiomics and deep learning for differentiating uterine serous carcinoma from endometrioid carcinoma: a multicenter retrospective study
Multiparametric MRI-based radiomics and deep learning for differentiating uterine serous carcinoma from endometrioid carcinoma: a multicenter retrospective study Open
Background Uterine serous carcinoma (USC) and endometrioid endometrial carcinoma (EEC) are distinct subtypes of endometrial cancer with markedly different prognoses and management strategies. Accurate preoperative differentiation between U…
View article: Association Between Proteasome 26S Subunit, Non-ATPase 3 Methylation and Insulin β Cell Apoptosis in Type 2 Diabetic Mellitus
Association Between Proteasome 26S Subunit, Non-ATPase 3 Methylation and Insulin β Cell Apoptosis in Type 2 Diabetic Mellitus Open
PSMD3 methylation might potentially influences cell apoptosis and proliferation in T2DM development which might be associated with activating USP14. This study offers an in-depth examination of PSMD3 methylation's molecular a…
View article: An MRI radiomics model for predicting a prostate-specific antigen response following abiraterone treatment in patients with metastatic castration-resistant prostate cancer
An MRI radiomics model for predicting a prostate-specific antigen response following abiraterone treatment in patients with metastatic castration-resistant prostate cancer Open
Objective To establish a combined radiomics-clinical model for the early prediction of a prostate-specific antigen(PSA) response in patients with metastatic castration-resistant prostate cancer(mCRPC) after treatment with abiraterone aceta…
View article: A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma
A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma Open
View article: Microbiota contribute to regulation of the gut-testis axis in seasonal spermatogenesis
Microbiota contribute to regulation of the gut-testis axis in seasonal spermatogenesis Open
Seasonal breeding is an important adaptive strategy for animals. Recent studies have highlighted the potential role of the gut microbiota in reproductive health. However, the relationship between the gut microbiota and reproduction in seas…
View article: 2-Bromopalmitate-Induced Intestinal Flora Changes and Testicular Dysfunction in Mice
2-Bromopalmitate-Induced Intestinal Flora Changes and Testicular Dysfunction in Mice Open
2-Bromopalmitate (2-BP) is a palmitoylation inhibitor that can prevent the binding of palmitic acid to proteins, thereby exhibiting significant effects in promoting inflammation and regulating the immune system. However, limited research h…
View article: Monkeypox virus protein H3L induces injuries in human and mouse
Monkeypox virus protein H3L induces injuries in human and mouse Open
View article: Regulation Mechanism of Nitrite Degradation in Lactobacillus plantarum WU14 Mediated by Fnr
Regulation Mechanism of Nitrite Degradation in Lactobacillus plantarum WU14 Mediated by Fnr Open
Fumarate and nitrate reduction regulatory protein (Fnr), as a global transcriptional regulator, could directly or indirectly regulate many genes in different metabolic pathways at the top of the bacterial transcription regulation network. …
View article: Arginine Biosynthesis Mediates Wulingzhi Extract Resistance to Busulfan-Induced Male Reproductive Toxicity
Arginine Biosynthesis Mediates Wulingzhi Extract Resistance to Busulfan-Induced Male Reproductive Toxicity Open
Busulfan, an indispensable medicine in cancer treatment, can cause serious reproductive system damage to males as a side effect of its otherwise excellent therapeutic results. Its widespread use has also caused its accumulation in the envi…
View article: A novel antibiotic 3-isopropylhexahydro-4H-pyrido[1,2-α]pyrazine-1,4(6H)-dione isolated from the thermophilic bacterium Bacillus licheniformis QX928
A novel antibiotic 3-isopropylhexahydro-4H-pyrido[1,2-α]pyrazine-1,4(6H)-dione isolated from the thermophilic bacterium Bacillus licheniformis QX928 Open
A microbial strain designated Bacillus licheniformis QX928 was screened from hot springs in Sichuan Province, China, and a compound generated in the culture of this strain clearly inhibited Pseudomonas aeruginosa ATCC27853. The measured mi…
View article: Trisomy 21-driven metabolite alterations are linked to cellular injuries in Down syndrome
Trisomy 21-driven metabolite alterations are linked to cellular injuries in Down syndrome Open
View article: Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system
Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system Open
Rationale: Regulatory processes of transcription factors (TFs) shape heart development and influence the adult heart's response to stress, contributing to cardiac disorders. Despite their significance, the precise mechanisms underpi…
View article: Identification of Diagnostic Biomarkers for Compensatory Liver Cirrhosis Based on Gut Microbiota and Urine Metabolomics Analyses
Identification of Diagnostic Biomarkers for Compensatory Liver Cirrhosis Based on Gut Microbiota and Urine Metabolomics Analyses Open
View article: Profilin1 Promotes Renal Tubular Epithelial Cell Apoptosis in Diabetic Nephropathy Through the Hedgehog Signaling Pathway
Profilin1 Promotes Renal Tubular Epithelial Cell Apoptosis in Diabetic Nephropathy Through the Hedgehog Signaling Pathway Open
PFN1 might play an integral role in the regulation of cell proliferation and apoptosis during DN development by activating the Hedgehog signaling pathway. This study provided molecular and bioinformatic characterizations of PFN1, and contr…
View article: A duplex nested RT-PCR method for monitoring porcine epidemic diarrhea virus and porcine delta-coronavirus
A duplex nested RT-PCR method for monitoring porcine epidemic diarrhea virus and porcine delta-coronavirus Open
· Background: Porcine epidemic diarrhea virus (PEDV) and porcine delta-coronavirus (PDCoV) are economically important pathogens that cause diarrhea in sows and acute death of newborn piglets. Moreover, the emerging porcine delta-coronaviru…
View article: Gender differences on perceptions of health risks and adaptation of climate change among primary healthcare workers in Guangdong Province
Gender differences on perceptions of health risks and adaptation of climate change among primary healthcare workers in Guangdong Province Open
BackgroundClimate change has resulted in long-term impacts on human health. Implementing efficient adaptation strategies among primary healthcare facilities is well determined by whether staff of different genders recognize the health risk…
View article: Atypical deletion of Williams–Beuren syndrome reveals the mechanism of neurodevelopmental disorders
Atypical deletion of Williams–Beuren syndrome reveals the mechanism of neurodevelopmental disorders Open
Genes associated with specific neurocognitive phenotypes in Williams–Beuren syndrome are still controversially discussed. This study identified nine patients with atypical deletions out of 111 patients with Williams–Beuren syndrome; these …
View article: Effect of gas compressibility on fluid field of air‐cooled turbo‐generator
Effect of gas compressibility on fluid field of air‐cooled turbo‐generator Open
The effect of gas compressibility on the fluid flow characteristics of a 350 MW air‐cooled turbo‐generator is investigated in this paper. Two gas models taking gas compressibility and incompressibility into account are established for nume…
View article: Integrated Strategies of Diverse Feature Selection Methods Identify Aging-Based Reliable Gene Signatures for Ischemic Cardiomyopathy
Integrated Strategies of Diverse Feature Selection Methods Identify Aging-Based Reliable Gene Signatures for Ischemic Cardiomyopathy Open
Objective: Ischemic cardiomyopathy (ICM) is a major cardiovascular state associated with prominently increased morbidity and mortality. Our purpose was to detect reliable gene signatures for ICM through integrated feature selection strateg…
View article: Downregulation of Uncoupling Protein 2(UCP2) Mediated by MicroRNA-762 Confers Cardioprotection and Participates in the Regulation of Dynamic Mitochondrial Homeostasis of Dynamin Related Protein1 (DRP1) After Myocardial Infarction in Mice
Downregulation of Uncoupling Protein 2(UCP2) Mediated by MicroRNA-762 Confers Cardioprotection and Participates in the Regulation of Dynamic Mitochondrial Homeostasis of Dynamin Related Protein1 (DRP1) After Myocardial Infarction in Mice Open
Acute myocardial infarction (MI) is one of the leading causes of death in the world, and its pathophysiological mechanisms have not been fully elucidated. The purpose of this study was to investigate the role and mechanism of uncoupling pr…
View article: SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways
SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways Open
Background: Given the importance of microvascular injury in infarct formation and expansion, development of therapeutic strategies for microvascular protection against myocardial ischemia/reperfusion injury (IRI) is of great interes…
View article: Differential diagnosis of parotid gland tumours: Application of SWI combined with DWI and DCE-MRI
Differential diagnosis of parotid gland tumours: Application of SWI combined with DWI and DCE-MRI Open
SWI offers incremental diagnostic value to DWI and DCE-MRI in the characterisation of parotid gland tumours.
View article: LncRNA PVT1 Knockdown Ameliorates Myocardial Ischemia Reperfusion Damage via Suppressing Gasdermin D-Mediated Pyroptosis in Cardiomyocytes
LncRNA PVT1 Knockdown Ameliorates Myocardial Ischemia Reperfusion Damage via Suppressing Gasdermin D-Mediated Pyroptosis in Cardiomyocytes Open
Objective: Myocardial ischemia reperfusion (I/R) damage is a life-threatening vascular emergency after myocardial infarction. Here, we observed the cardioprotective effect of long non-coding RNA (lncRNA) PVT1 knockdown against myocardial I…
View article: Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells
Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells Open
Background and Aim. The senescence of human bone marrow mesenchymal stem cells (hBMSCs) can be induced by oxidative stress, but the mechanism by which it occurs is not yet clear. Here, we performed an investigation on the pathogenesis of h…
View article: Multi-factor regulatory network and different clusters in hypertrophic obstructive cardiomyopathy
Multi-factor regulatory network and different clusters in hypertrophic obstructive cardiomyopathy Open
Background Practical biosignatures and thorough understanding of regulatory processes of hypertrophic obstructive cardiomyopathy (HOCM) are still lacking. Methods Firstly, public data from GSE36961 and GSE89714 datasets of Gene Expression …
View article: Intracellular Delivery of Proteins into Living Cells by Low-Molecular-Weight Polyethyleneimine
Intracellular Delivery of Proteins into Living Cells by Low-Molecular-Weight Polyethyleneimine Open
Collectively, PEI1200-based delivery system provided an alternative strategy to direct protein delivery in high efficiency and safety, offering increased potential applications in clinical biomedicine.
View article: Analysis of multi-factor regulated network and different clusters in hypertrophic obstructive cardiomyopathy
Analysis of multi-factor regulated network and different clusters in hypertrophic obstructive cardiomyopathy Open
We herein explored the regulatory network between lncRNA, miRNAs, mRNAs, and TFs in the HOCM and divided HOCM samples into different clusters to identify key genes and regulatory factors. The four gene sets from GEO, GENE and OMIM database…
View article: Atypical Deletion of Williams-beuren Syndrome Reveals the Mechanism of Neurodevelopmental Disorders
Atypical Deletion of Williams-beuren Syndrome Reveals the Mechanism of Neurodevelopmental Disorders Open
Background The Williams-Beuren syndrome (WBS) is a multiple phylogenetic disorder, caused by the hemizygous deletion of 1.55 to 1.84 Mb on chromosome 7q11.23, which encodes a fragment of 26 to 28 genes. Among these genes, the deletion of t…
View article: <i>FLNC</i> and <i>MYLK2</i> Gene Mutations in a Chinese Family with Different Phenotypes of Cardiomyopathy
<i>FLNC</i> and <i>MYLK2</i> Gene Mutations in a Chinese Family with Different Phenotypes of Cardiomyopathy Open
Mutations in the sarcomeric protein filamin C (FLNC) gene have been linked to hypertrophic cardiomyopathy (HCM), as they have been determined to increase the risk of ventricular arrhythmia and sudden death. Thus, in this study, we identifi…