Shaoyi Chen
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View article: Deep Learning-Based Blind Denoising for Distributed Acoustic Sensing Seismic Data With Self-Supervised and Transfer Learning
Deep Learning-Based Blind Denoising for Distributed Acoustic Sensing Seismic Data With Self-Supervised and Transfer Learning Open
A distributed acoustic sensing (DAS) technology, extensively utilized in the seabed geological exploration, ocean current analysis, and marine seismic monitoring, faces challenges due to the presence of various noise types in sensing signa…
View article: Influence of phenolic co-pigments on the stability of major anthocyanin in blueberry wine and color changes during storage
Influence of phenolic co-pigments on the stability of major anthocyanin in blueberry wine and color changes during storage Open
View article: Evaluation of clinical and safety outcomes of cancer vaccines in patients with advanced non-small cell lung cancer after first-line therapy: a systematic review and meta-analysis
Evaluation of clinical and safety outcomes of cancer vaccines in patients with advanced non-small cell lung cancer after first-line therapy: a systematic review and meta-analysis Open
20240484580, 20230484314, 2023YFF0723500, 2021RU002, 82173386, RZ2022-04.
View article: The Stochastic Hopf Bifurcation and Vibrational Response of a Double Pendulum System Under Delayed Feedback Control
The Stochastic Hopf Bifurcation and Vibrational Response of a Double Pendulum System Under Delayed Feedback Control Open
In this paper, we investigate the nonlinear dynamic behavior of a cart–double pendulum system with single time delay feedback control. Based on the center manifold theorem and stochastic averaging method, a reduced-order dynamic model of t…
View article: TIP-seq: A Single-cell Multiomics Approach for Simultaneous Transcriptome and Intracellular Protein Profiling
TIP-seq: A Single-cell Multiomics Approach for Simultaneous Transcriptome and Intracellular Protein Profiling Open
Single-cell multiomics technologies have significantly advanced our understanding of cellular heterogeneity; however, the concurrent profiling of mRNA transcripts and target proteins continues to pose a substantial challenge. To bridge the…
View article: Local earthquake response on the submarine communication cable in the northern South China Sea
Local earthquake response on the submarine communication cable in the northern South China Sea Open
As a new seismological monitoring technology, distributed acoustic sensing (DAS) not only provides a high-precision seismic observation method, but also uses undersea communication fiber or dark fiber to reduce the layout cost, and support…
View article: Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer
Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer Open
View article: Comparison of the capability and performance of “photosynthesis” and “structure” indices in retrieving vegetation phenology in the Northern Hemisphere
Comparison of the capability and performance of “photosynthesis” and “structure” indices in retrieving vegetation phenology in the Northern Hemisphere Open
Phenology refers to the natural responses of vegetation to environmental factors and disturbances throughout its life cycle. Focusing on the mid-high latitudes vegetation in the Northern Hemisphere, this study reported the differences in p…
View article: An mRNA-Based Respiratory Syncytial Virus Vaccine Elicits Strong Neutralizing Antibody Responses and Protects Rodents Without Vaccine-Associated Enhanced Respiratory Disease
An mRNA-Based Respiratory Syncytial Virus Vaccine Elicits Strong Neutralizing Antibody Responses and Protects Rodents Without Vaccine-Associated Enhanced Respiratory Disease Open
Background: Respiratory syncytial virus (RSV) causes the most common type of severe lower respiratory tract infection worldwide, and the fusion (F) protein is a target for neutralizing antibodies and vaccine development. This study aimed t…
View article: DAShip: A Large-Scale Annotated Dataset for Ship Detection Using Distributed Acoustic Sensing Technique
DAShip: A Large-Scale Annotated Dataset for Ship Detection Using Distributed Acoustic Sensing Technique Open
Ship detection and identification is the key part of the maritime monitoring and safety. Ship monitoring methods based on coastal video surveillance, satellite imagery, and synthetic aperture radar have been well developed. As the emerging…
View article: Field Experiments of Distributed Acoustic Sensing Measurements
Field Experiments of Distributed Acoustic Sensing Measurements Open
Modern, large bridges and tunnels represent important nodes in transportation arteries and have a significant impact on the development of transportation. The health and safety monitoring of these structures has always been a significant c…
View article: Synthetic circRNA therapeutics: innovations, strategies, and future horizons
Synthetic circRNA therapeutics: innovations, strategies, and future horizons Open
Small molecule drugs are increasingly emerging as innovative and effective treatments for various diseases, with mRNA therapeutics being a notable representative. The success of COVID‐19 vaccines has underscored the transformative potentia…
View article: N1‐methylpseudouridine modification level correlates with protein expression, immunogenicity, and stability of mRNA
N1‐methylpseudouridine modification level correlates with protein expression, immunogenicity, and stability of mRNA Open
View article: Local Earthquake Response on the Submarine Communication Cable in The Northern South China Sea
Local Earthquake Response on the Submarine Communication Cable in The Northern South China Sea Open
As a new seismological monitoring technology, distributed acoustic sensing (DAS) not only provides a high-precision seismic observation method, but also uses undersea communication fiber or dark fiber to reduce the layout cost, and support…
View article: Restoring expression of tumour suppressor PTEN by engineered circular RNA‐enhanced Osimertinib sensitivity in non‐small cell lung cancer
Restoring expression of tumour suppressor PTEN by engineered circular RNA‐enhanced Osimertinib sensitivity in non‐small cell lung cancer Open
View article: Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury
Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury Open
Bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment are among the most common morbidities affecting preterm infants. Although BPD is a predictor of poor neurodevelopmental outcomes, it is currently uncertain how BPD contribu…
View article: A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses
A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses Open
Highly pathogenic viruses from family Phenuiviridae , which are mainly transmitted by arthropods, have intermittently sparked epidemics worldwide. In particular, tick-borne bandaviruses, such as severe fever with thrombocytopenia syndrome …
View article: IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice Open
Background Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common morbidities affecting extremely premature infants and is a leading cause of severe vision impairment in child…
View article: GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice Open
View article: The applications and techniques of organoids in head and neck cancer therapy
The applications and techniques of organoids in head and neck cancer therapy Open
Head and neck cancer (HNC) is one of the most common cancers on the planet, with approximately 600,000 new cases diagnosed and 300,000 deaths every year. Research into the biological basis of HNC has advanced slowly over the past decades, …
View article: GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice Open
Background: Neonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our previous studies in neonatal rodent models have shown that hyperoxia stimulates the brain’s inflammasome pat…
View article: GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice
GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice Open
View article: SHH/GLI2-TGF-β1 feedback loop between cancer cells and tumor-associated macrophages maintains epithelial-mesenchymal transition and endoplasmic reticulum homeostasis in cholangiocarcinoma
SHH/GLI2-TGF-β1 feedback loop between cancer cells and tumor-associated macrophages maintains epithelial-mesenchymal transition and endoplasmic reticulum homeostasis in cholangiocarcinoma Open
Cholangiocarcinoma cells regulated TAM polarization and TGF-β1 secretion via a paracrine SHH signaling pathway, and in turn, TAMs promoted the growth, EMT, and ER homeostasis of cholangiocarcinoma cells via TGF-β1.
View article: Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmonary Dysplasia Complicated By Pulmonary Hypertension
Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmonary Dysplasia Complicated By Pulmonary Hypertension Open
Mesenchymal stem cell (MSC) extracellular vesicles (EVs) have beneficial effects in preclinical bronchopulmonary dysplasia and pulmonary hypertension (BPD-PH) models. The optimal source, dosing, route, and duration of effects are however u…
View article: Effects of ambient air pollution, fresh fruit and vegetable intakes as well as maternal psychosocial stress on the outcome of newborn otoacoustic emission hearing screening
Effects of ambient air pollution, fresh fruit and vegetable intakes as well as maternal psychosocial stress on the outcome of newborn otoacoustic emission hearing screening Open
Background Newborn hearing screening results indicated that more than 40% of the detected infants had no recognized risk factors. To determine whether maternal exposure to ambient air pollutants and experience of stressful life event, as w…
View article: Tumor-associated macrophages promote cholangiocarcinoma progression via exosomal Circ_0020256
Tumor-associated macrophages promote cholangiocarcinoma progression via exosomal Circ_0020256 Open
This study investigated the exosomal circular RNAs (CircRNAs) produced by tumor-associated macrophages and delivered into the microenvironment of cholangiocarcinoma cells in order to use them as molecular targets for clinical therapy. Tumo…
View article: Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury
Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury Open
Background Mechanical ventilation of preterm newborns causes lung injury and is associated with poor neurodevelopmental outcomes. However, the mechanistic links between ventilation-induced lung injury (VILI) and brain injury is not well de…
View article: Author Correction: Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats
Author Correction: Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats Open
View article: Transcription factor CDX2 up-regulates proto-oncogenic miR-744 via a promoter activation mechanism in non-small-cell lung cancer
Transcription factor CDX2 up-regulates proto-oncogenic miR-744 via a promoter activation mechanism in non-small-cell lung cancer Open
In summary, our results confirmed for the first time the regulatory mechanism of CDX2 on miR-744 transcription and provided a potential mechanism for CDX2 as an oncogene in lung cancer.
View article: Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats
Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats Open