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View article: Case Report: Streptococcus dysgalactiae ssp. dysgalactiae bloodstream infections in patients with breast cancer after radiotherapy and chemotherapy
Case Report: Streptococcus dysgalactiae ssp. dysgalactiae bloodstream infections in patients with breast cancer after radiotherapy and chemotherapy Open
Bloodstream infections are life-threatening conditions in patients with breast cancer, especially among older individuals. Although the most common risk factor in these patients with tumors is the use of severe neutropenia secondary to mye…
View article: Critical roles of m6A methylation in cardiovascular diseases
Critical roles of m6A methylation in cardiovascular diseases Open
Cardiovascular diseases (CVDs) have been established as a major cause of mortality globally. However, the exact pathogenesis remains obscure. N6-methyladenosine (m 6 A) methylation is the most common epigenetic modification on mRNAs regula…
View article: Clinicopathological features of papillary thyroid carcinoma in HIV-infected patients
Clinicopathological features of papillary thyroid carcinoma in HIV-infected patients Open
Background Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, with an increasing incidence over the last decades. Human immunodeficiency virus (HIV)-induced immune deficiency was one of risk factors for cancer tumor…
View article: Clinical diagnosis and treatment of primary thyroid tuberculosis: a retrospective study
Clinical diagnosis and treatment of primary thyroid tuberculosis: a retrospective study Open
PTT is a rare disease. It is important to improve the preoperative diagnosis. Preoperative diagnostic accuracy relies on increased awareness of the disease and appropriate use of preoperative diagnostic methods, such as PCR detection, fine…
View article: [Retracted] miR‑137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12
[Retracted] miR‑137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Open
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the western blotting data shown in Figs. 4D and 5B were strikingly similar to data appearing in different form in other a…
View article: A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid‐induced cellular responses
A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid‐induced cellular responses Open
G protein‐coupled receptors regulate a variety of cellular responses and have been considered as therapeutic targets for human diseases. Lysophosphatidic acid receptor 1 (LPA1) is a receptor for bioactive lysophospholipid, LPA. LPA/LPA1‐me…
View article: Ultrasonographic Assessment of Anatomic Relationship Between the Internal Jugular Vein and the Common Carotid Artery in Infants and Children After ETT or LMA Insertion: A Prospective Observational Study
Ultrasonographic Assessment of Anatomic Relationship Between the Internal Jugular Vein and the Common Carotid Artery in Infants and Children After ETT or LMA Insertion: A Prospective Observational Study Open
Background: Central venous catheterization is used for fluid management and infusion of drugs, but it is difficult to perform and carries a high incidence of complications in infants and children. In adults, the anatomic relationshi…
View article: MicroRNA-363-3p downregulation in papillary thyroid cancer inhibits tumor progression by targeting NOB1
MicroRNA-363-3p downregulation in papillary thyroid cancer inhibits tumor progression by targeting NOB1 Open
MicroRNA-363-3 p (miR-363–3 p) has been reported to play a crucial role in tumor development and progression, and function as a tumor suppressor in many types of cancer. In our previous studies, we found that miRNA-363–3 p inhibited papill…
View article: SCF FBXW17 E3 ubiquitin ligase regulates FBXL19 stability and cell migration
SCF FBXW17 E3 ubiquitin ligase regulates FBXL19 stability and cell migration Open
The Skp1‐Cul1‐F‐box protein (SCF) E3 ligase complex is one of the largest ubiquitin E3 ligase families. FBXL19, a F‐box protein in SCF FBXL19 E3 ligase complex, regulates a variety of cellular responses including cell migration. We have sh…
View article: Intracystic Hemorrhage and Its Management During Ultrasound-Guided Percutaneous Microwave Ablation for Cystic Thyroid Nodules
Intracystic Hemorrhage and Its Management During Ultrasound-Guided Percutaneous Microwave Ablation for Cystic Thyroid Nodules Open
Background: Intracystic hemorrhage can present occasionally during ultrasound-guided percutaneous microwave ablation (PMWA) for cystic thyroid nodules. It can affect treatment outcome, can lead to ablation failure, and even conversi…
View article: Proteasome Inhibitors Diminish c-Met Expression and Induce Cell Death in Non-Small Cell Lung Cancer Cells
Proteasome Inhibitors Diminish c-Met Expression and Induce Cell Death in Non-Small Cell Lung Cancer Cells Open
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and accounts for 85% of all lung carcinomas. The hepatocyte growth factor receptor (c-Met) has been considered as a potential therapeutic target for NSCLC. Proteasom…
View article: LncRNA LINC00152 promotes laryngeal cancer progression by sponging miR-613
LncRNA LINC00152 promotes laryngeal cancer progression by sponging miR-613 Open
Background Long noncoding RNA (lncRNA) LINC00152 (CYTOR) has been reported to be upregulated and to serve as a diagnostic biomarker in multiple types of cancers, including laryngeal squamous cell cancer (LSCC). However, the functional role…
View article: Two distinct E3 ligases, SCF <sup>FBXL19</sup> and HECW1, degrade thyroid transcription factor 1 in normal thyroid epithelial and follicular thyroid carcinoma cells, respectively
Two distinct E3 ligases, SCF <sup>FBXL19</sup> and HECW1, degrade thyroid transcription factor 1 in normal thyroid epithelial and follicular thyroid carcinoma cells, respectively Open
Thyroid transcription factor 1 (TTF1) regulates the tissue‐specific expression of genes. However, the molecular regulation of TTF1 in thyroid normal and carcinoma cells has not been revealed. Here we identify 2 distinct ubiquitin E3 ligase…
View article: The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system
The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system Open
View article: The HECT ubiquitin E3 ligase Smurf2 degrades μ-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells
The HECT ubiquitin E3 ligase Smurf2 degrades μ-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells Open
Opioids are widely used for relieving clinical acute or chronic pain. The biological effects of opioids are through activating μ-opioid receptor 1 (MOR1). Most studies have focused on the consequences of agonist-induced MOR1 phosphorylatio…
View article: Benign-Appearing Thyroid Follicles in Cervical Lymph Nodes: A Report of 3 Cases and a Review of the Literature
Benign-Appearing Thyroid Follicles in Cervical Lymph Nodes: A Report of 3 Cases and a Review of the Literature Open
Thyroid carcinoma tissue is frequently found in cervical lymph nodes following metastasis of thyroid, and particularly, thyroid papillary carcinoma. However, thyroid follicles without any malignant characteristics also are frequently detec…
View article: Histone acetyltransferase CBP promotes function of SCF FBXL19 ubiquitin E3 ligase by acetylation and stabilization of its F‐box protein subunit
Histone acetyltransferase CBP promotes function of SCF FBXL19 ubiquitin E3 ligase by acetylation and stabilization of its F‐box protein subunit Open
Ubiquitin E3 ligases mediate ubiquitination and degradation of intracellular proteins. We have shown that a relatively new Skp, Cullin, F‐box (SCF) protein E3 ligase, SCF FBXL19, has an anti‐inflammatory effect and controls actin cytoskele…
View article: Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation
Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation Open
The stability of the histone acetyltransferase CBP must be maintained to promote cytokine release and inflammation in the lung.
View article: MicroRNA-363-3p inhibits papillary thyroid carcinoma progression by targeting PIK3CA.
MicroRNA-363-3p inhibits papillary thyroid carcinoma progression by targeting PIK3CA. Open
MicroRNA-363-3p (miR-363-3p) reportedly plays crucial roles in tumor development and progression in many types of cancers. However, its role in papillary thyroid carcinoma (PTC) remain largely unclear. We therefore investigated the functio…
View article: Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury
Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury Open
View article: miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12
miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Open
Accumulating evidence has shown that aberrantly expressed microRNAs (miRs) are extensively involved in tumorigenesis. microRNA-137 (miR-137) has been reported as a tumor suppressor in various types of cancer. However, the biological functi…
View article: microRNA-141 inhibits thyroid cancer cell growth and metastasis by targeting insulin receptor substrate 2.
microRNA-141 inhibits thyroid cancer cell growth and metastasis by targeting insulin receptor substrate 2. Open
microRNA-141 (miR-141), a member of the miR-200 family, and has been reported to involve in tumor initiation and development in many types of cancers. However, the function and underlying molecular mechanism of miR-141 in thyroid cancer re…
View article: Post-intubation tracheal stenosis after management of complicated aortic dissection: a case series
Post-intubation tracheal stenosis after management of complicated aortic dissection: a case series Open
Continuous monitoring of cuff pressure and regular cuff palpation are necessary to minimize the incidence of tracheal stenosis. If the patients have concomitant local or systemic infection, adequate preventive measures should be taken to r…
View article: Fiberoptic Bronchoscopy-Assisted Endotracheal Intubation in a Patient With a Large Tracheal Tumor
Fiberoptic Bronchoscopy-Assisted Endotracheal Intubation in a Patient With a Large Tracheal Tumor Open
In the event of a high degree of airway obstruction, endotracheal intubation can be impossible and even dangerous, because it can cause complete airway obstruction, especially in patients with high tracheal lesions. However, a smaller endo…