Shao‐Zhen Lin
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View article: Fibrillar adhesions are the primary integrin complexes shaped by matrix topography
Fibrillar adhesions are the primary integrin complexes shaped by matrix topography Open
Mechanisms of matrix topography recognition are poorly understood. Here, we show that α5β1-integrin mediated fibrillar adhesions serve this function. While on planar substrates, their formation requires fibronectin secretion, tensins, and …
View article: Data and Code for "Noninvasive rheological inference from stable flows in confined tissues" submission
Data and Code for "Noninvasive rheological inference from stable flows in confined tissues" submission Open
This Zenodo record contains the code and processed datasets used for image-based analysis of epithelial monolayer dynamics in micropatterned ring geometries, associated to the preprint publication Karnat et al. "Noninvasive rheological inf…
View article: SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer Open
Elucidating the complex network of communication between tumour cells is central to understanding cell fate decisions and progression of pancreatic ductal adenocarcinoma (PDAC)1,2. We previously showed that constant suppression …
View article: A multicellular star-shaped actin network underpins epithelial organization and connectivity
A multicellular star-shaped actin network underpins epithelial organization and connectivity Open
Epithelial tissues withstand external stresses while maintaining structural stability. Bicellular junctions and the actomyosin network support epithelial integrity, packing and remodelling. While their role in development and disease are w…
View article: Regulation of intercellular viscosity by E-cadherin-dependent phosphorylation of EGFR in collective cell migration
Regulation of intercellular viscosity by E-cadherin-dependent phosphorylation of EGFR in collective cell migration Open
Collective cell migration is crucial in various physiological processes, including wound healing, morphogenesis, and cancer metastasis. Adherens Junctions (AJs) play a pivotal role in regulating cell cohesion and migration dynamics during …
View article: Spontaneous flows in active smectics with dislocations
Spontaneous flows in active smectics with dislocations Open
We construct a hydrodynamic theory of active smectics A in two-dimensional space, including the creation/annihilation and motility of dislocations with Burgers' number $\pm1$. We derive analytical criteria on the set of parameters that lea…
View article: Curvature-induced clustering of cell adhesion proteins
Curvature-induced clustering of cell adhesion proteins Open
Cell adhesion proteins typically form stable clusters that anchor the cell membrane to its environment. Several works have suggested that cell membrane protein clusters can emerge from a local feedback between the membrane curvature and th…
View article: Membrane Tilt Drives Phase Separation of Adhesion Receptors
Membrane Tilt Drives Phase Separation of Adhesion Receptors Open
Cell adhesion receptors are transmembrane proteins that bind cells to their environment. These proteins typically cluster into disk-shaped or linear structures. Here, we show that such clustering patterns spontaneously emerge when the rece…
View article: E-cadherin-dependent phosphorylation of EGFR governs a homeostatic feedback loop controlling intercellular junction viscosity and collective migration modes
E-cadherin-dependent phosphorylation of EGFR governs a homeostatic feedback loop controlling intercellular junction viscosity and collective migration modes Open
Actomyosin tension has been shown to be a ubiquitous driver of tissue morphogenesis 1, 2 . The Rho pathway, a prominent regulatory network influencing cortical tension, plays a central role in both tissue reorganisation and cell migration …
View article: The Golgi microtubules regulate single cell durotaxis
The Golgi microtubules regulate single cell durotaxis Open
View article: Curvature-induced clustering of cell adhesion proteins
Curvature-induced clustering of cell adhesion proteins Open
Cell adhesion proteins typically form stable clusters that anchor the cell membrane to its environment. Several works have suggested that cell membrane protein clusters can emerge from a local feedback between the membrane curvature and th…
View article: Characterizing mechanical properties of epithelial monolayers based on indentation
Characterizing mechanical properties of epithelial monolayers based on indentation Open
View article: Tilt-induced clustering of cell adhesion proteins
Tilt-induced clustering of cell adhesion proteins Open
Cell adhesion proteins are transmembrane proteins that bind cells to their environment. These proteins typically cluster into disk-shaped or linear structures. Here we show that such clustering patterns spontaneously emerge when the protei…
View article: Two-point optical manipulation reveals mechanosensitive remodeling of cell–cell contacts in vivo
Two-point optical manipulation reveals mechanosensitive remodeling of cell–cell contacts in vivo Open
Biological tissues acquire reproducible shapes during development through dynamic cell behaviors. Most of these behaviors involve the remodeling of cell–cell contacts. During epithelial morphogenesis, contractile actomyosin networks remode…
View article: Structure and Rheology in Vertex Models under Cell-Shape-Dependent Active Stresses
Structure and Rheology in Vertex Models under Cell-Shape-Dependent Active Stresses Open
Biological cells can actively tune their intracellular architecture according to their overall shape. Here we explore the rheological implication of such coupling in a minimal model of a dense cellular material where each cell exerts an ac…
View article: Mechanical stress driven by rigidity sensing governs epithelial stability
Mechanical stress driven by rigidity sensing governs epithelial stability Open
View article: Drosophila mechanical nociceptors preferentially sense localized poking
Drosophila mechanical nociceptors preferentially sense localized poking Open
Mechanical nociception is an evolutionarily conserved sensory process required for the survival of living organisms. Previous studies have revealed much about the neural circuits and sensory molecules in mechanical nociception, but the cel…
View article: Author response: Drosophila mechanical nociceptors preferentially sense localized poking
Author response: Drosophila mechanical nociceptors preferentially sense localized poking Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mechanica…
View article: Active Nematic Flows over Curved Surfaces
Active Nematic Flows over Curved Surfaces Open
Cell monolayers are a central model system in the study of tissue biophysics. In vivo, epithelial tissues are curved on the scale of microns, and the curvature's role in the onset of spontaneous tissue flows is still not well understood. H…
View article: <i>Alcanivorax borkumensis</i>Biofilms Enhance Oil Degradation By Interfacial Tubulation
<i>Alcanivorax borkumensis</i>Biofilms Enhance Oil Degradation By Interfacial Tubulation Open
Alcanivorax borkumensis are prominent actors in oil spill bioremediation; however, the interfacial dynamics of their biofilms and its role in oil degradation remain unclear. Longitudinal tracking of biofilm-covered oil microdroplets using …
View article: Data used in the paper (Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo)
Data used in the paper (Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo) Open
Data used in the paper (Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo)
View article: Data used in the paper (Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo)
Data used in the paper (Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo) Open
Data used in the paper (Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo)
View article: Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo
Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo Open
Biological tissues acquire reproducible shapes during development through dynamic cell behaviors. These events involve the remodeling of cell contacts driven by active cytoskeletal contractile forces. However how cell-cell contacts remodel…
View article: Tissue fluidization by cell-shape-controlled active stresses
Tissue fluidization by cell-shape-controlled active stresses Open
Biological cells can actively tune their intracellular architecture according to their overall shape. Here we explore the rheological implication of such coupling in a minimal model of a dense cellular material where each cell exerts an ac…
View article: Mechanical stress driven by rigidity sensing governs epithelial stability
Mechanical stress driven by rigidity sensing governs epithelial stability Open
Epithelia act as a barrier against environmental stress and abrasion and i n vivo they are continuously exposed to environments of various mechanical properties. The impact of this environment on epithelial integrity remains elusive. By cu…
View article: Active nematic flows on curved surfaces
Active nematic flows on curved surfaces Open
Cell monolayers are a central model system to tissue biophysics. In vivo, epithelial tissues are curved on the scale of microns, and curvature's role in the onset of spontaneous tissue flows is still not well-understood. Here, we present a…
View article: Drosophila Mechanical Nociceptors Preferentially Sense Localized Poking
Drosophila Mechanical Nociceptors Preferentially Sense Localized Poking Open
Mechanical nociception is an evolutionarily conserved sensory process required for the survival of living organisms. Previous studies have revealed much about the neural circuits and key sensory molecules in mechanical nociception, but the…
View article: Implementation of cellular bulk stresses in vertex models of biological tissues
Implementation of cellular bulk stresses in vertex models of biological tissues Open
View article: Energetics of mesoscale cell turbulence in two-dimensional monolayers
Energetics of mesoscale cell turbulence in two-dimensional monolayers Open
Investigation of energy mechanisms at the collective cell scale is a challenge for understanding various biological processes, such as embryonic development and tumor metastasis. Here we investigate the energetics of self-sustained mesosca…
View article: The Golgi microtubules regulate single cell durotaxis
The Golgi microtubules regulate single cell durotaxis Open