Shaozhuang Liu
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View article: Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction
Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction Open
Background and Aims Obesity is a global health challenge significantly increasing cardiovascular disease (CVD) burden. Effective prevention and treatment necessitate targeting early pathological changes, particularly obesity-induced endoth…
View article: Nanotherapeutic formulations of enzyme inhibitors targeting cancer and neuroinflammation: An updated review
Nanotherapeutic formulations of enzyme inhibitors targeting cancer and neuroinflammation: An updated review Open
With roughly 19.3 million new cases and 10 million deaths from cancer in 2020. Cancer is one of the leading causes of the global increase in mortality rates. Approximately 90 % of cancer fatalities are caused by metastases, which are the h…
View article: Protective effect of micheliolide against inflammation and oxidative stress in asthma through the MAPK/NF-κB signalling pathway
Protective effect of micheliolide against inflammation and oxidative stress in asthma through the MAPK/NF-κB signalling pathway Open
View article: Adipose ZFP36 protects against diet-induced obesity and insulin resistance
Adipose ZFP36 protects against diet-induced obesity and insulin resistance Open
This study suggests that ZFP36 in adipose tissue plays an important role in diet-induced obesity, and identifies a novel molecular signaling pathway of ZFP36/RNF128/Sirt1 involved in obesity.
View article: Bariatric Surgery Impact on Women with Polycystic Ovary Syndrome: A Prospective Cohort Study
Bariatric Surgery Impact on Women with Polycystic Ovary Syndrome: A Prospective Cohort Study Open
Bariatric surgery has emerged as a promising intervention for obese women with polycystic ovary syndrome (PCOS), a condition strongly associated with obesity and anovulatory infertility. While weight management is a key therapeutic strateg…
View article: Impact of sleeve gastrectomy on the periodontal status of patients with and without type 2 diabetes: a 1-year prospective real-world study
Impact of sleeve gastrectomy on the periodontal status of patients with and without type 2 diabetes: a 1-year prospective real-world study Open
Background Periodontitis is a chronic inflammatory disease potentially associated with obesity and type 2 diabetes (T2D). Sleeve gastrectomy (SG) has shown substantial effect on weight loss and treatment of T2D. However, there is no direct…
View article: Total weight loss rather than preoperative body mass index correlates with remission of irregular menstruation after sleeve gastrectomy in patients with polycystic ovary syndrome
Total weight loss rather than preoperative body mass index correlates with remission of irregular menstruation after sleeve gastrectomy in patients with polycystic ovary syndrome Open
Introduction Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. Some retrospective studies with small sample sizes have reported that bariatric metabolic surgery is effective in remission …
View article: The current status and challenges of perioperative management of patients with a BMI of greater than or equal to 50 kg/m2 undergoing bariatric surgery in China: a multicenter cross-sectional study
The current status and challenges of perioperative management of patients with a BMI of greater than or equal to 50 kg/m2 undergoing bariatric surgery in China: a multicenter cross-sectional study Open
Background: Performing bariatric surgery on patients with a BMI of over 50 kg/m 2 is challenging. This study aimed to explore the status and challenges related to the perioperative management of such patients in China. Materials and method…
View article: Sex dimorphism in the effect and predictors of weight loss after sleeve gastrectomy
Sex dimorphism in the effect and predictors of weight loss after sleeve gastrectomy Open
Background No sex-specific guidelines for surgical anti-obesity strategies have been proposed, partially due to the controversy regarding sex-related differences in weight loss after bariatric metabolic surgery. Objectives To explore sex d…
View article: Risk Factors and Clinical Prediction Nomogram for Fatty Pancreas in Obese Population
Risk Factors and Clinical Prediction Nomogram for Fatty Pancreas in Obese Population Open
View article: Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice
Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice Open
Endothelial dysfunction represents a major cardiovascular risk factor for hypertension. Sp1 and Sp3 belong to the specificity protein and Krüppel-like transcription factor families. They are ubiquitously expressed and closely associated wi…
View article: Hypermethylation of RNF125 promotes autophagy-induced oxidative stress in asthma by increasing HMGB1 stability
Hypermethylation of RNF125 promotes autophagy-induced oxidative stress in asthma by increasing HMGB1 stability Open
Asthma is a global chronic airway disease. The expression and role of RNF125, an E3 ubiquitin ligase, in asthma remain uncertain. In this study, we revealed that RNF125 was downregulated in the bronchial epithelium of mice and patients wit…
View article: Pulmonary Function Test and Obstructive Sleep Apnea Hypopnea Syndrome in Obese Adults: A Retrospective Study
Pulmonary Function Test and Obstructive Sleep Apnea Hypopnea Syndrome in Obese Adults: A Retrospective Study Open
R25% was an independent risk factor for severe OSA in obese individuals, while RV/TLC was also an independent risk factor in those aged 35 to 60. Pulmonary function tests (PFTs), particularly IOS levels, are recommended to assess severe OS…
View article: β-cell function and insulin dynamics in obese patients with and without diabetes after sleeve gastrectomy
β-cell function and insulin dynamics in obese patients with and without diabetes after sleeve gastrectomy Open
Improved β-cell function seems to be essential for better glucose homeostasis after Roux-en-Y gastric bypass but is less studied after sleeve gastrectomy (SG). We evaluated the effects of SG on β-cell function in obese patients with diabet…
View article: β-cell function and insulin dynamics in obese patients with and without diabetes after sleeve gastrectomy
β-cell function and insulin dynamics in obese patients with and without diabetes after sleeve gastrectomy Open
Improved β-cell function seems to be essential for better glucose homeostasis after Roux-en-Y gastric bypass but is less studied after sleeve gastrectomy (SG). We evaluated the effects of SG on β-cell function in obese patients with diabet…
View article: SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice
SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice Open
Background Depression and dysosmia have been regarded as primary neurological symptoms in COVID-19 patients, the mechanism of which remains unclear. Current studies have demonstrated that the SARS-CoV-2 envelope (E) protein is a pro-inflam…
View article: Author Correction: Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice
Author Correction: Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice Open
View article: Association between the systemic immune-inflammation index and kidney stone: A cross-sectional study of NHANES 2007-2018
Association between the systemic immune-inflammation index and kidney stone: A cross-sectional study of NHANES 2007-2018 Open
Background The incidence rate of kidney stones increased over the past decades globally, which brought medical expenditure and social burden. The systemic immune-inflammatory index (SII) was initially identified as a prognosis of multiple …
View article: Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice
Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice Open
View article: SARS-CoV-2 Envelope protein triggers depression and dysosmia via TLR2 mediated neuroinflammation
SARS-CoV-2 Envelope protein triggers depression and dysosmia via TLR2 mediated neuroinflammation Open
Background Depression and dysosmia have been regarded as the main neurological symptoms in COVID-19 patients, the mechanism of which remains unclear. Current studies have demonstrated that SARS-CoV-2 envelope protein served as a pro-inflam…
View article: Predictors of Remission Of Oligo-/Amenorrhea After Sleeve Gastrectomy in Patients with Polycystic Ovary Syndrome: A Prospective Multi-Center Cohort Study
Predictors of Remission Of Oligo-/Amenorrhea After Sleeve Gastrectomy in Patients with Polycystic Ovary Syndrome: A Prospective Multi-Center Cohort Study Open
View article: Additional file 4 of SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice
Additional file 4 of SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice Open
Additional file 4: Table S1. Target gene.
View article: Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats
Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats Open
DJB elevates intraduodenal BA levels and activates the duodenal BA signaling pathway, which may upregulate duodenal SIRT1 and further contribute to improved glucose homeostasis after DJB.
View article: Metabolic Surgery on Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Metabolic Surgery on Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Open
Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease that is closely related to obesity. Metabolic surgery ameliorates a series of clinical manifestations and related comorbidities of PCOS. However, the overall …
View article: Data for: Central GLP-1 contributes to improved brain function and glucose uptake after duodenum-jejunum bypass on diabetic rats
Data for: Central GLP-1 contributes to improved brain function and glucose uptake after duodenum-jejunum bypass on diabetic rats Open
Background Remission of type 2 diabetes mellitus (T2DM) following bariatric surgery has been intensively studied while the changes in brain function, glucose uptake and its underlying mechanism remains largely unknown. Methods Duodenum-jej…
View article: Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species‐mediated PI3K/AKT pathway
Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species‐mediated PI3K/AKT pathway Open
Prostate cancer is a major health concern in males worldwide, owing to its high incidence. Sparstolonin B (SsnB), a component of the Chinese herbal medicine Sparganium stoloniferum , is used to treat many diseases. However, the effects and…
View article: Overexpression of Karyopherin Subunit alpha 2 (KPNA2) Predicts Unfavorable Prognosis and Promotes Bladder Cancer Tumorigenicity via the P53 Pathway
Overexpression of Karyopherin Subunit alpha 2 (KPNA2) Predicts Unfavorable Prognosis and Promotes Bladder Cancer Tumorigenicity via the P53 Pathway Open
BACKGROUND We sought to investigate the expression of KPNA2 in bladder cancer (BC) and its relationship with prognosis, and to analyze the potential mechanism of KPNA2 in promoting BC progression. MATERIAL AND METHODS The RNA-seq data on B…
View article: Improved FGF21 Sensitivity and Restored FGF21 Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats After Duodenal-Jejunal Bypass and Sleeve Gastrectomy
Improved FGF21 Sensitivity and Restored FGF21 Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats After Duodenal-Jejunal Bypass and Sleeve Gastrectomy Open
Objective: Bariatric surgery can profoundly improve glucose and lipid metabolism in diabetic rats. Fibroblast growth factor 21 (FGF21) is an important hormone with multiple metabolic beneficial effects. Alteration in serum FGF21 lev…
View article: Adipose HuR protects against diet-induced obesity and insulin resistance
Adipose HuR protects against diet-induced obesity and insulin resistance Open
View article: Laparoscopic gastrectomy for early gastric cancer and the risk factors of lymph node metastasis
Laparoscopic gastrectomy for early gastric cancer and the risk factors of lymph node metastasis Open
Tumour size, depth of invasion, morphological classification and blood vessel invasion were predictive risk factors for LNM in EGC. We propose that EGC patients with those risk factors should be accepted gastrectomy with LN dissection.