Sharan Janjuha
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View article: Predicting adenine base editing efficiencies in different cellular contexts by deep learning
Predicting adenine base editing efficiencies in different cellular contexts by deep learning Open
View article: Publisher Correction: Machine learning prediction of prime editing efficiency across diverse chromatin contexts
Publisher Correction: Machine learning prediction of prime editing efficiency across diverse chromatin contexts Open
View article: Machine learning prediction of prime editing efficiency across diverse chromatin contexts
Machine learning prediction of prime editing efficiency across diverse chromatin contexts Open
View article: Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning
Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning Open
Prime editing is a powerful genome editing technology, but its efficiency varies depending on the pegRNA design and target locus. Existing computational models for predicting prime editing rates are limited by their focus on specific edit …
View article: Prime editing of the β<sub>1</sub>adrenoceptor in the brain reprograms mouse behavior
Prime editing of the β<sub>1</sub>adrenoceptor in the brain reprograms mouse behavior Open
Summary Prime editing is a highly versatile genome editing technology that holds great potential for treating genetic diseases 1, 2 . While in vivo prime editing has recently been conducted in the brain, liver, heart, and retina 3–6 , appl…
View article: Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing
Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing Open
Pancreatic ductal adenocarcinoma (PDA) is an inherently immune cell deprived tumor, characterized by desmoplastic stroma and suppressive immune cells. Here we systematically dissect PDA intrinsic mechanisms of immune evasion by in vitro an…
View article: A single-cell atlas of <i>de novo</i> β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish
A single-cell atlas of <i>de novo</i> β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish Open
Regeneration-competent species possess the ability to reverse the progression of severe diseases by restoring the function of the damaged tissue. However, the cellular dynamics underlying this capability remain unexplored. Here, we have us…
View article: Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens
Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens Open
View article: Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing
Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing Open
Pancreatic ductal adenocarcinoma (PDA) is an inherently immune cell deprived tumor, characterized by desmoplastic stroma and suppressive immune cells. Here we systematically dissected PDA intrinsic mechanisms of immune evasion by in vitro …
View article: A single-cell atlas of <i>de novo</i> β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish
A single-cell atlas of <i>de novo</i> β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish Open
Regeneration-competent species possess the ability to reverse the progression of severe diseases by restoring the function of the damaged tissue. However, the cellular dynamics underlying this capability remain unexplored. Here, we use sin…
View article: In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA
In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA Open
View article: Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens
Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens Open
Base editors are chimeric ribonucleoprotein complexes consisting of a DNA-targeting CRISPR-Cas module and a single-stranded DNA deaminase. They enable conversion of C•G into T•A base pairs and vice versa on genomic DNA. While base editors …
View article: Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance Open
View article: Machine learning based classification of cells into chronological stages using single-cell transcriptomics
Machine learning based classification of cells into chronological stages using single-cell transcriptomics Open
View article: Up-regulation of the kinase gene SGK1 by progesterone activates the AP-1–NDRG1 axis in both PR-positive and -negative breast cancer cells
Up-regulation of the kinase gene SGK1 by progesterone activates the AP-1–NDRG1 axis in both PR-positive and -negative breast cancer cells Open
Preoperative progesterone intervention has been shown to confer a survival benefit to breast cancer patients independently of their progesterone receptor (PR) status. This observation raises the question how progesterone affects the outcom…
View article: Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets
Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets Open
Pancreatic beta-cells respond to increasing blood glucose concentrations by secreting the hormone insulin. The dysfunction of beta-cells leads to hyperglycemia and severe, life-threatening consequences. Understanding how the beta-cells ope…
View article: Machine learning based classification of cells into chronological stages using single-cell transcriptomics
Machine learning based classification of cells into chronological stages using single-cell transcriptomics Open
Age-associated deterioration of cellular physiology leads to pathological conditions. The ability to detect premature aging could provide a window for preventive therapies against age-related diseases. However, the techniques for determini…
View article: Simultaneous lineage tracing and cell-type identification using CRISPR–Cas9-induced genetic scars
Simultaneous lineage tracing and cell-type identification using CRISPR–Cas9-induced genetic scars Open
View article: Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish
Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish Open
The pancreatic islet, a cellular community harboring the insulin-producing beta-cells, is known to undergo age-related alterations. However, only a handful of signals associated with aging have been identified. By comparing beta-cells from…
View article: Author response: Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish
Author response: Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish Open
View article: Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth Open