Sharen Lee
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View article: The Role of Ventricular Arrhythmias Inducibility in Arrhythmic Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy: A Meta‐Analysis of Observational Studies
The Role of Ventricular Arrhythmias Inducibility in Arrhythmic Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy: A Meta‐Analysis of Observational Studies Open
Background The identification of arrhythmogenic right ventricular cardiomyopathy (ARVC) patients at risk for fatal arrhythmic events is of great importance in clinical practice. Conflicting data exist regarding the role of electrophysiolog…
View article: Effects of Warfarin on the Risks of Mortality, Acute Heart Failure, and Infection Resolution in Patients With Infective Endocarditis: A Target Trial Emulation
Effects of Warfarin on the Risks of Mortality, Acute Heart Failure, and Infection Resolution in Patients With Infective Endocarditis: A Target Trial Emulation Open
Background Infective endocarditis (IE) can be complicated by acute heart failure and bacteremia, which can account for increased mortality. The role of anticoagulation with warfarin in IE is controversial. This study aimed to study the eff…
View article: Comparison of New‐Onset Peripheral Artery Disease in Patients With Type 2 Diabetes Exposed to Sodium–Glucose Cotransporter‐2 Inhibitors, Dipeptidyl Peptidase‐4 Inhibitors, or Glucagon‐Like Peptide‐1 Agonists: A Population‐Based Cohort Study
Comparison of New‐Onset Peripheral Artery Disease in Patients With Type 2 Diabetes Exposed to Sodium–Glucose Cotransporter‐2 Inhibitors, Dipeptidyl Peptidase‐4 Inhibitors, or Glucagon‐Like Peptide‐1 Agonists: A Population‐Based Cohort Study Open
Background Sodium‐glucose cotransporter‐2 inhibitors (SGLT2Is), dipeptidyl peptidase‐4 inhibitors (DPP4Is), and glucagon‐like peptide‐1 receptor agonists have been associated with improved cardiovascular outcomes and prognosis. The compara…
View article: aTrial arrhythmias in inhEriTed aRrhythmIa Syndromes: results from the TETRIS study
aTrial arrhythmias in inhEriTed aRrhythmIa Syndromes: results from the TETRIS study Open
Aims Little is known about the distribution and clinical course of patients with inherited arrhythmia syndrome (IAS) and concomitant atrial arrhythmias (AAs). The aim of the study is (i) to characterize the distribution of AAs in patients …
View article: Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for new-onset gastric cancer and gastric diseases in patients with type 2 diabetes mellitus: a population-based cohort study
Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for new-onset gastric cancer and gastric diseases in patients with type 2 diabetes mellitus: a population-based cohort study Open
Objective To compare the risks of gastric cancer and other gastric diseases in patients with type-2 diabetes mellitus (T2DM) exposed to sodium-glucose cotransporter 2 inhibitors (SGLT2I), dipeptidyl peptidase-4 inhibitors (DPP4I) or glucag…
View article: Lower Risks of New-Onset Hepatocellular Carcinoma in Patients With Type 2 Diabetes Mellitus Treated With SGLT2 Inhibitors Versus DPP4 Inhibitors
Lower Risks of New-Onset Hepatocellular Carcinoma in Patients With Type 2 Diabetes Mellitus Treated With SGLT2 Inhibitors Versus DPP4 Inhibitors Open
Background: Type 2 diabetes mellitus (T2DM) may be a risk factor for development of hepatocellular carcinoma (HCC). The association between risk of developing HCC and treatment with sodium-glucose cotransporter-2 inhibitors (SGLT2i) versus…
View article: Lower Risk of Incident Cataracts and Diabetic Retinopathy amongst Individuals Treated with Sodium Glucose Cotransporter-2 Inhibitor Compared to Dipeptidyl Peptidase-4 Inhibitor in Type 2 Diabetes Mellitus
Lower Risk of Incident Cataracts and Diabetic Retinopathy amongst Individuals Treated with Sodium Glucose Cotransporter-2 Inhibitor Compared to Dipeptidyl Peptidase-4 Inhibitor in Type 2 Diabetes Mellitus Open
Background/Aims Type 2 diabetes mellitus (T2DM) is an extremely prevalent disease with multisystem complications. We aim to compare the effects of two common glucose lowering medications; sodium glucose co-transporter 2 inhibitors (SGLT2I)…
View article: PR prolongation as a predictor of atrial fibrillation onset: A state-of-the-art review
PR prolongation as a predictor of atrial fibrillation onset: A state-of-the-art review Open
First-degree atrioventricular block (1-AVB), characterized by a PR interval exceeding 200 milliseconds, has traditionally been perceived as a benign cardiac condition. Recently, this perception has been challenged by investigations that in…
View article: Metformin use is associated with lower risks of dementia, anxiety and depression: The Hong Kong Diabetes Study
Metformin use is associated with lower risks of dementia, anxiety and depression: The Hong Kong Diabetes Study Open
Aims To compare the effects of metformin and sulphonylurea on new-onset dementia, anxiety disorder and depression, and all-cause mortality in patients with type 2 diabetes mellitus. Methods This is a retrospective population-based cohort s…
View article: Effects of Warfarin on the Risks of Mortality, Acute Heart Failure, and Infection Resolution in Patients with Infective Endocarditis: A Target Trial Emulation
Effects of Warfarin on the Risks of Mortality, Acute Heart Failure, and Infection Resolution in Patients with Infective Endocarditis: A Target Trial Emulation Open
View article: Comparisons of New-Onset Prostate Cancer in Type 2 Diabetes Mellitus Exposed to Sglt2i, Dpp4i and Glp1: A Population-Based Cohort Study
Comparisons of New-Onset Prostate Cancer in Type 2 Diabetes Mellitus Exposed to Sglt2i, Dpp4i and Glp1: A Population-Based Cohort Study Open
View article: New-onset prostate cancer in type 2 diabetes mellitus exposed to the SGLT2I, DPP4I and GLP1a: A population-based cohort study
New-onset prostate cancer in type 2 diabetes mellitus exposed to the SGLT2I, DPP4I and GLP1a: A population-based cohort study Open
Background Sodium-glucose cotransporter 2 inhibitors (SGLT2I) have been suggested to reduce new-onset cancer amongst type-2 diabetes mellitus (T2DM) patients. Objective This real-world study aims to compare the risks of prostate cancer bet…
View article: Initiation of warfarin is associated with decreased mortality in patients with infective endocarditis: A population-based cohort study
Initiation of warfarin is associated with decreased mortality in patients with infective endocarditis: A population-based cohort study Open
In this propensity score-matched, population-based, prospective cohort study from Hong Kong, warfarin use within 14 days of IE diagnosis was associated with a 50 % decrease in the risk of all-cause mortality, albeit with higher risk of int…
View article: Healthcare Big Data in Hong Kong: Development and Implementation of Artificial Intelligence-Enhanced Predictive Models for Risk Stratification
Healthcare Big Data in Hong Kong: Development and Implementation of Artificial Intelligence-Enhanced Predictive Models for Risk Stratification Open
Routinely collected electronic health records (EHRs) data contain a vast amount of valuable information for conducting epidemiological studies. With the right tools, we can gain insights into disease processes and development, identify the…
View article: Editorial: Machine learning and data science in heart failure and stroke
Editorial: Machine learning and data science in heart failure and stroke Open
EDITORIAL article Front. Cardiovasc. Med., 22 August 2023Sec. Heart Failure and Transplantation Volume 10 - 2023 | https://doi.org/10.3389/fcvm.2023.1275739
View article: Comparisons of new-onset peripheral arterial disease in Type 2 diabetes mellitus patients exposed to SGLT2I, DPP4I or GLP1a: a population-based cohort study
Comparisons of new-onset peripheral arterial disease in Type 2 diabetes mellitus patients exposed to SGLT2I, DPP4I or GLP1a: a population-based cohort study Open
Background Sodium-glucose cotransporter-2 inhibitors (SGLT2I) have been suggested to have beneficial effects against atherosclerotic cardiovascular disease. The comparative risks of new onset peripheral arterial disease (PAD) between SGLT2…
View article: New-onset infective endocarditis in diabetic patients receiving SGLT2I, DPP4I and GLP1a: A population-based cohort study
New-onset infective endocarditis in diabetic patients receiving SGLT2I, DPP4I and GLP1a: A population-based cohort study Open
Background Sodium-glucose cotransporter-2 inhibitors (SGLT2I) have been suggested to have beneficial effects against infection. However, the comparative risks of new onset infective endocarditis between SGLT2Is, dipeptidyl peptidase-4 inhi…
View article: Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study
Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study Open
This population-based cohort study investigated the risk factors of incident dementia and vascular dementia in type 2 diabetic patients (≥45 years old) attending the Hong Kong Hospital Authority between 1st January and 31st December 2009.O…
View article: Secular trends of health care resource utilization and costs between Brugada syndrome and congenital long QT syndrome: A territory‐wide study
Secular trends of health care resource utilization and costs between Brugada syndrome and congenital long QT syndrome: A territory‐wide study Open
Background Health care resource utilization (HCRU) and costs are important metrics of health care burden, but they have rarely been explored in the setting of cardiac ion channelopathies. Hypothesis This study tested the hypothesis that at…
View article: Comparing the risks of new-onset gastric cancer or gastric diseases in type 2 diabetes mellitus patients exposed to SGLT2I, DPP4I or GLP1A: a population-based cohort study
Comparing the risks of new-onset gastric cancer or gastric diseases in type 2 diabetes mellitus patients exposed to SGLT2I, DPP4I or GLP1A: a population-based cohort study Open
Objective To compare the risks of gastric cancer and other gastric diseases upon exposed to sodium-glucose cotransporter 2 inhibitors (SGLT2I), dipeptidyl peptidase-4 inhibitors (DPP4I) and glucagon-like peptide-1 receptor agonists (GLP1A)…
View article: 114 Attendance-related healthcare resource utilisation and costs in patients with long qt syndrome in hong kong: a retrospective cohort study
114 Attendance-related healthcare resource utilisation and costs in patients with long qt syndrome in hong kong: a retrospective cohort study Open
Introduction The understanding of healthcare resource utilisation and its related costs is crucial for optimizing resource allocation in the healthcare setting. There is currently a paucity of published studies investigating healthcare cos…
View article: 199 Alkaline phosphatase variability and heart failure in type 2 diabetes mellitus: the hong kong diabetes study
199 Alkaline phosphatase variability and heart failure in type 2 diabetes mellitus: the hong kong diabetes study Open
Objective To investigate the associations of alkaline phosphatase (ALP) variability measures with adverse cardiovascular outcomes in type 2 diabetes mellitus. Method This population-based cohort study included patients with type 2 diabetes…
View article: 211 Aspirin is associated with lower risks of severe covid-19 disease: a population-based study
211 Aspirin is associated with lower risks of severe covid-19 disease: a population-based study Open
Introduction The use of aspirin has been hypothesized to improve severe clinical outcomes in COVID-19 infection. The present study aims to evaluate the effect of both antecedent and inpatient aspirin use, individually and concomitant with …
View article: Sodium‐glucose cotransporter 2 inhibitors versus dipeptidyl peptidase 4 inhibitors on new‐onset overall cancer in Type 2 diabetes mellitus: A population‐based study
Sodium‐glucose cotransporter 2 inhibitors versus dipeptidyl peptidase 4 inhibitors on new‐onset overall cancer in Type 2 diabetes mellitus: A population‐based study Open
Background Cancer is currently the second leading cause of death globally. There is much uncertainty regarding the comparative risks of new‐onset overall cancer and pre‐specified cancer for Type 2 diabetes mellitus (T2DM) patients on sodiu…
View article: Precision Medicine for Cardiac Ion Channelopathies in Hong Kong: From Case Reports to Identification of Novel Genetic Variants and Development of Risk Prediction Tools using Population-based Datasets
Precision Medicine for Cardiac Ion Channelopathies in Hong Kong: From Case Reports to Identification of Novel Genetic Variants and Development of Risk Prediction Tools using Population-based Datasets Open
Congenital cardiac ion channelopathies refer to a set of inherited conditions characterized by abnormalities in the structure and/or function of ion channels, their associated proteins or other signalling components, predisposing affected …
View article: Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study
Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study Open
Background This study aims to assess the prevalence of atrial cardiomyopathy (ACM) in patients with new-onset metabolic syndrome (MetS) and investigate whether ACM could be a predictor of hospital admission for cardiovascular (CV) events. …
View article: Comparing sodium-glucose cotransporter 2 inhibitors and dipeptidyl peptidase-4 inhibitors on new-onset depression: a propensity score-matched study in Hong Kong
Comparing sodium-glucose cotransporter 2 inhibitors and dipeptidyl peptidase-4 inhibitors on new-onset depression: a propensity score-matched study in Hong Kong Open
View article: Lower risks of sodium glucose cotransporter 2 (SGLT2) inhibitors compared to dipeptidyl peptidase-4 (DPP4) inhibitors for new-onset hip fracture risks in patients with type-2 diabetes: A propensity score-matched study with competing risk analysis
Lower risks of sodium glucose cotransporter 2 (SGLT2) inhibitors compared to dipeptidyl peptidase-4 (DPP4) inhibitors for new-onset hip fracture risks in patients with type-2 diabetes: A propensity score-matched study with competing risk analysis Open
Purpose This study aimed to compare the effects of sodium glucose cotransporter 2 inhibitors (SGLT2I) and dipeptidyl peptidase-4 inhibitors (DPP4I) on new-onset hip fractures. Methods This was a retrospective population-based cohort study …
View article: Risk of diabetes mellitus among users of immune checkpoint inhibitors: A population‐based cohort study
Risk of diabetes mellitus among users of immune checkpoint inhibitors: A population‐based cohort study Open
Background Immune checkpoint inhibitors (ICIs) are increasingly established cancer therapeutics, but they are associated with new‐onset diabetes mellitus (DM). Such risks have not been adequately quantified, and between‐class and ‐sex diff…
View article: Risk stratification of sudden cardiac death in asymptomatic female Brugada syndrome patients: A literature review
Risk stratification of sudden cardiac death in asymptomatic female Brugada syndrome patients: A literature review Open
Background and Objectives Risk stratification in Brugada syndrome remains a difficult problem. Given the male predominance of this disease and their elevated risks of arrhythmic events, affected females have received less attention. It is …