Explanipedia

Staphylococcus aureus Infections and Human Intestinal Microbiota Open

Aotong Liu, Shari Garrett, Wanqing Hong, Jilei Zhang · 2024

Staphylococcus aureus (S. aureus) is a common pathogen that can cause many human diseases, such as skin infection, food poisoning, endocarditis, and sepsis. These diseases can be minor infections or life-threatening, requiring complex medi…

Axin1‘s mystique in manipulating microbiome amidst colitis Open

Shari Garrett, Monica C. Asada, Jun Sun · 2023

Classically, Axin1 is considered a regulator of Wnt/β-catenin signaling. However, Axin1's roles in host-microbial interactions have been unknown. Our recent study has demonstrated that deletion of intestinal epithelial Axin1 in epithelial …

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota Open

Shari Garrett, Yongguo Zhang, Yinglin Xia, Jun Sun · 2023

Intestinal vitamin D receptor protects against extraintestinal breast cancer tumorigenesis Open

Yongguo Zhang, Yinglin Xia, Jilei Zhang, Shreya Deb, Shari Garrett , et al. · 2023

The microbiota plays critical roles in regulating the function and health of the intestine and extraintestinal organs. A fundamental question is whether an intestinal-microbiome-breast axis exists during the development of breast cancer. I…

Intestinal epithelial Axin1 deficiency protects against colitis via altered gut microbiota Open

Shari Garrett, Yongguo Zhang, Yinglin Xia, Jun Sun · 2022

Background and Aims Intestinal homeostasis is maintained by specialized host cells and the gut microbiota. Wnt/β-catenin signaling is essential for gastrointestinal development and homeostasis, and its dysregulation has been implicated in …

Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis Open

Yongguo Zhang, Shari Garrett, Robert E. Carroll, Yinglin Xia, Jun Sun · 2022

Extraintestinal roles of intestinal vitamin D receptor in protecting against dysbiosis and tumorigenesis in breast cancer Open

Yongguo Zhang, Jilei Zhang, Shreya Deb, Shari Garrett, Yinglin Xia , et al. · 2022

Original data for the ‘‘extraintestinal roles of intestinal vitamin D receptor in protecting against dysbiosis and tumorigenesis in breast cancer’’ manuscript

Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis Open

Yongguo Zhang, Destiny Ogbu, Shari Garrett, Yinglin Xia, Jun Sun · 2021

Background Emerging evidence has demonstrated that microbiota directly affects the enteric neuron system (ENS) and smooth muscle cell functions via metabolic products or endogenous bacterial components. Amyotrophic Lateral Sclerosis is a n…

Vitamin D Receptor Upregulates Tight Junction Protein Claudin-5 against Tumorigenesis Open

Yongguo Zhang, Shari Garrett, Robert E. Carroll, Yinglin Xia, Jun Sun · 2021

Background/Objective Tight junctions (TJs) are essential for barrier integrity, inflammation, and cancer. The TJ protein Claudin-5 in the epithelia forms paracellular barriers and pores for permeability. Vitamin D and the vitamin D recepto…

Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis Open

Yongguo Zhang, Destiny Ogbu, Shari Garrett, Yinglin Xia, Jun Sun · 2021

Amyotrophic Lateral Sclerosis is a neuromuscular disease characterized by the progressive death of motor neurons and muscle atrophy. The gastrointestinal symptoms in ALS patients were largely ignored or underestimated. The relationship bet…

Gastrointestinal symptoms, pathophysiology, and treatment in COVID-19 Open

Jilei Zhang, Shari Garrett, Jun Sun · 2020

Lactic Acid Bacteria Isolated From Korean Kimchi Activate the Vitamin D Receptor–autophagy Signaling Pathways Open

Rong Lu, Mei Shang, Yongguo Zhang, Yang Jiao, Yinglin Xia , et al. · 2020

Background Probiotic lactic acid bacteria (LAB) have been used in the anti-inflammation and anti-infection process of various diseases, including inflammatory bowel disease (IBD). Vitamin D receptor (VDR) plays an essential role in pathoge…

Sa1908 – Aberrant Enteric Neuromuscular System and Dysbiosis in Mice with Amyotrophic Lateral Sclerosis Open

Yongguo Zhang, Rong Lü, Shari Garrett, Yinglin Xia, Jun Sun · 2019

Salmonella Infection in Chronic Inflammation and Gastrointestinal Cancer Open

Lang Zha, Shari Garrett, Jun Sun · 2019

Salmonella not only causes acute infections, but can also cause patients to become chronic “asymptomatic” carriers. Salmonella has been verified as a pathogenic factor that contributes to chronic inflammation and carcinogenesis. This revie…

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