Sharif Arar
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View article: Tau Oligomers in Alzheimer’s Disease: Modulation Effect of Osmolytes on Amplified Brain-Derived Tau Oligomers
Tau Oligomers in Alzheimer’s Disease: Modulation Effect of Osmolytes on Amplified Brain-Derived Tau Oligomers Open
Tau is bound to microtubules and plays a key role in their assembly and spatial organization. Under pathological conditions, tau detaches from the microtubules and develops a propensity to self-aggregate into soluble tau oligomers (TauO), …
View article: Characterization of Water-Soluble Inorganic Ions and Carbonaceous Aerosols in the Urban Atmosphere in Amman, Jordan
Characterization of Water-Soluble Inorganic Ions and Carbonaceous Aerosols in the Urban Atmosphere in Amman, Jordan Open
The Eastern Mediterranean is a unique region for air pollution because it is the crossroads between three continents exchanging air pollution transported between Africa, Asia, and Europe. Here, we investigated urban particulate matter (PM)…
View article: Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation
Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation Open
The pathological misfolding and aggregation of the microtubule associated protein tau (MAPT), a full length Tau2N4R with 441aa, is considered the principal disease relevant constituent in tauopathies including Alzheimer's disease (AD) with…
View article: Characterization of Water-Soluble Inorganic Ions and Carbonaceous Aerosols in the Urban Atmosphere in Amman, Jordan
Characterization of Water-Soluble Inorganic Ions and Carbonaceous Aerosols in the Urban Atmosphere in Amman, Jordan Open
View article: Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics
Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics Open
Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still…
View article: Identification and Separation of the Degradation Products of Vildagliptin Tablets and Raw Material using LC-MS and NMR, and then Exploration of the Corresponding Degradation Pathways
Identification and Separation of the Degradation Products of Vildagliptin Tablets and Raw Material using LC-MS and NMR, and then Exploration of the Corresponding Degradation Pathways Open
A gradient high performance liquid chromatography (HPLC) method has been developed for the qualitative and quantitative analyses of vildagliptin related substances. This method is based on using of RP-C18 (250 × 4.6 mm×5µm) and gradient el…
View article: Organic and Elemental Carbon in the Urban Background in an Eastern Mediterranean City
Organic and Elemental Carbon in the Urban Background in an Eastern Mediterranean City Open
The Mediterranean region is an important area for air pollution as it is the crossroads between three continents; therefore, the concentrations of atmospheric aerosol particles are influenced by emissions from Africa, Asia, and Europe. Her…
View article: Monitoring of Dioxins/Furans (PCDD/Fs) in Smoke of Charcoal Grilled Meat-Restaurants in Amman-Jordan
Monitoring of Dioxins/Furans (PCDD/Fs) in Smoke of Charcoal Grilled Meat-Restaurants in Amman-Jordan Open
PCDDs /Fs were investigated in outdoor air of charcoal grilled meat-restaurants in Jordan. Restaurants were given the codes (S, Z, G, B, and J). Levels of PCDDs/Fs depend on the quantity of used charcoal, amount of grilled meat, and sampli…
View article: Monitoring of polycyclic aromatic hydrocarbons (PAHs) in smoke of charcoal grilled meat-restaurants in Amman, Jordan
Monitoring of polycyclic aromatic hydrocarbons (PAHs) in smoke of charcoal grilled meat-restaurants in Amman, Jordan Open
Polycyclic aromatic hydrocarbons (PAHs) were investigated in the outdoor air of charcoal-grilled meat-restaurants in Amman/Jordan. The studied restaurants were given the codes (S, Z, G, B, and J). PAHs were extracted using QuEChERS method …
View article: Forced degradation studies of vildagliptin raw material alone and in the presence of excipients using HPLC-UV analysis.
Forced degradation studies of vildagliptin raw material alone and in the presence of excipients using HPLC-UV analysis. Open
The chemical stability of a drug formulation can change the potency and safety of the finished medicinal product. A forced degradation study can be a good method to examine the stability of a drug molecule and formulation. An RP-HPLC metho…
View article: Particulate Matter Concentrations in a Middle Eastern City – An Insight to Sand and Dust Storm Episodes
Particulate Matter Concentrations in a Middle Eastern City – An Insight to Sand and Dust Storm Episodes Open
In this study, the particulate matter mass (PM10 and PM2.5) concentrations we measured during May 2018–March 2019 in an urban atmosphere of Amman, Jordan. The results showed that the annual mean PM10 concentration was 64 ± 39 µg m–3 and th…
View article: Levels of PCDDs/PCDFs in waste incineration ash of some Jordanian hospitals using GC/MS
Levels of PCDDs/PCDFs in waste incineration ash of some Jordanian hospitals using GC/MS Open
An investigative study on the occurrence of the unintentionally produced toxic and carcinogenic polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzo furans (PCDFs) compounds was conducted in 11 bottom ash samples of hospital wa…
View article: Elemental Contamination in Indoor Floor Dust and Its Correlation with PAHs, Fungi, and Gram+/− Bacteria
Elemental Contamination in Indoor Floor Dust and Its Correlation with PAHs, Fungi, and Gram+/− Bacteria Open
In this study, we performed elemental analysis for floor dust samples collected in Jordanian microenvironments (dwellings and educational building). We performed intercorrelation and cluster analysis between the elemental, polyaromatic hyd…
View article: Screening of (Aminoalkylindols) Cannabinoids in smoking products by GC-EI/MS in Jordan: Liquid-liquid extraction optimization.
Screening of (Aminoalkylindols) Cannabinoids in smoking products by GC-EI/MS in Jordan: Liquid-liquid extraction optimization. Open
I N THIS work a screening study in Jordan was conducted on identification of herbal smoking mixtures containing recently new marketed synthetic cannabinoids (aminoalkylindols) (XLR-11, AB-CHMINACA, AB-FUBINACA isomers) which were responsib…
View article: Levels of polyaromatic hydrocarbons (PAHs) in sediment samples from selected Jordanian dams
Levels of polyaromatic hydrocarbons (PAHs) in sediment samples from selected Jordanian dams Open
An experimental study was carried out on sediment of five Jordanian dams namely Tannur, Mujib, Karamah, King Talal, and Wadi ElArab to assess the polycyclic aromatic hydrocarbon (PAH) concentrations by using GC/MS. King Talal dam had highe…
View article: A Predictive Model for Steady State Ozone Concentration at an Urban-Coastal Site
A Predictive Model for Steady State Ozone Concentration at an Urban-Coastal Site Open
Ground level ozone (O3) plays an important role in controlling the oxidation budget in the boundary layer and thus affects the environment and causes severe health disorders. Ozone gas, being one of the well-known greenhouse gases, althoug…
View article: CCDC 1541598: Experimental Crystal Structure Determination
CCDC 1541598: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A new solvent extraction method with gas chromatography–Mass spectrometry for bisphenol a determination in canned foods
A new solvent extraction method with gas chromatography–Mass spectrometry for bisphenol a determination in canned foods Open
A new reliable simple solvent extraction method for the endocrine disruptor bisphenol A (BPA) in canned food was developed employing an aqueous basic extraction solution of 0.25 M K 2 CO 3 /0.10 M NaOH after spiking with BPA-d 16 as intern…
View article: Synthesis and cytotoxic activity of 4-<i>O</i>-β-D-galactopyranosyl derivatives of phenolic acids esters
Synthesis and cytotoxic activity of 4-<i>O</i>-β-D-galactopyranosyl derivatives of phenolic acids esters Open
The glycosylation of naturally occurring phenolic acids has a significant impact on their solubility, stability and physiochemical properties. D-Galactose residue was found to form a part of glycoconjugates in several tissues and involved …
View article: Amino- and thiol-modified microporous silicalite-1 and mesoporous MCM-48 materials as potential effective adsorbents for Pb(II) in polluted aquatic systems
Amino- and thiol-modified microporous silicalite-1 and mesoporous MCM-48 materials as potential effective adsorbents for Pb(II) in polluted aquatic systems Open
Aluminum-free zeolite silicalite-1 and the ordered mesoporous silicates Mobile Crystalline Material No. 48 (MCM-48) were prepared and functionalized with 3-aminopropyltriethoxysilane (APTES) and 3-mercaptopropyltrimethoxysilane (MPTMS) for…
View article: Anaerobic Cr(VI) Bioaccumulation: Application to Industrial Wastewater and Soil Matrices in Jordan
Anaerobic Cr(VI) Bioaccumulation: Application to Industrial Wastewater and Soil Matrices in Jordan Open