Sharmila Anandasabapathy

Multiscale modeling of drug-induced liver injury from organ to lobule Open

Alon Malka-Markovitz, Stelian Camara Dit Pinto, Mohammed Cherkaoui, S Levine, Sharmila Anandasabapathy , et al. · 2025

A virtual scalable model of the Hepatic Lobule for acetaminophen hepatotoxicity prediction Open

Stelian Camara Dit Pinto, Jalal Cherkaoui, Debarshi Ghosh, Valentine Cazaubon, Kenza E. Benzeroual , et al. · 2024

Cancer burden in low-income and middle-income countries Open

Sharmila Anandasabapathy, Chite Asirwa, Surbhi Grover, Chemtai Mungo · 2024

Developing the OpenFlexure Microscope towards medical use: technical and social challenges of developing globally accessible hardware for healthcare Open

Joe Knapper, Freya Whiteford, Daniel Rosen, W. J. Wadsworth, Julian Stirling , et al. · 2024

The OpenFlexure Microscope is an accessible, three-dimensional-printed robotic microscope, with sufficient image quality to resolve diagnostic features including parasites and cancerous cells. As access to lab-grade microscopes is a major …

Use of topical methylene blue to image nuclear morphometry with a low-cost scanning darkfield microendoscope Open

Huayu Hou, Jennifer Carns, Richard A. Schwarz, Ann M. Gillenwater, Sharmila Anandasabapathy , et al. · 2024

Our approach enables real-time microscopic evaluation of nuclear patterns and has the potential to be a powerful noninvasive tool for early cancer detection.

Developing the OpenFlexure Microscope towards medical use: Technical and social challenges of developing globally accessible hardware for healthcare Open

Joe Knapper, Freya Whiteford, Daniel Rosen, W. J. Wadsworth, Julian Stirling , et al. · 2024

The OpenFlexure Microscope is an accessible, 3Dprinted robotic microscope, with sufficient image quality to resolve diagnostic features including parasites and cancerous cells. As access to lab-grade microscopes is a major challenge in glo…

Deep-learning-based image super-resolution of an end-expandable optical fiber probe for application in esophageal cancer diagnostics Open

Xiaohui Zhang, Mimi C. Tan, Mansour Nabil, Sujita Kumar Kar, Shaleen Vasavada , et al. · 2024

This work suggests avenues for development of DL-SR-enabled sparse image reconstruction to improve high-yield EC screening and similar clinical applications.

JoVE Video Dataset Open

Е В Петрова, Huan Xu, Brodus A. Franklin, Laila Woc-Colburn, Sharmila Anandasabapathy · 2024

Handwashing is an easy and simple way for healthcare providers to maintain a safe and healthy environment for both themselves and the patient. The following handwashing protocol should be used before and after patient contact.

Utility of a low-cost 3-D printed microscope for evaluating esophageal biopsies Open

Daniel Rosen, Evandro Sobroza de Mello, Sadhna Dhingra, Sanford M. Dawsey, Joe Knapper , et al. · 2024

Gambian Mothers Lack Obstetric Danger Sign Knowledge, But Educational Intervention Shows Promise Open

Kara J. Shannon, Jocelyn Burridge, Brodus A. Franklin, Sheena Bhushan, Susan G. Hilsenbeck , et al. · 2024

Women had low knowledge of obstetric danger signs, and true awareness of danger signs was remarkably lower than self-perceived knowledge. However, patients exhibited proper healthcare-seeking behavior when danger signs arose. Findings sugg…

Deployment and assessment of a deep learning model for real-time detection of anal precancer with high frame rate high-resolution microendoscopy Open

David Brenes, Alex Kortum, Jackson B. Coole, Jennifer Carns, Richard A. Schwarz , et al. · 2023

Image Enhanced Endoscopy in Esophageal Squamous Cell Carcinoma Open

Shaleen Vasavada, Sharmila Anandasabapathy · 2023

Esophageal Squamous Cell Carcinoma (ESCC) accounts for a significant portion of esophageal cancer cases worldwide, particularly in high-risk regions like China, Iran, and eastern Africa. It is often diagnosed at advanced stages, leading to…

Deep learning-based image super-resolution of a novel end-expandable optical fiber probe for application in esophageal cancer diagnostics Open

Xiaohui Zhang, Mimi C. Tan, Mansour Nabil, Sujita Kumar Kar, Shaleen Vasavada , et al. · 2023

Significance: Endoscopic screening for esophageal cancer may enable early cancer diagnosis and treatment. While optical microendoscopic technology has shown promise in improving specificity, the limited field of view (<1 mm) significantly …

Integrating Social Determinants of Health into Ethical Digital Simulations Open

Kristin M. Kostick, Vasiliki Rahimzadeh, Sharmila Anandasabapathy, Meghan E. Hurley, Anika Sonig , et al. · 2023

Click to increase image sizeClick to decrease image sizeThis article refers to:Epistemic Rights and Responsibilities of Digital Simulacra for Biomedicine Additional informationFundingThis work was supported by National Center for Advancing…

Automated In Vivo High-Resolution Imaging to Detect Human Papillomavirus–Associated Anal Precancer in Persons Living With HIV Open

David Brenes, Alex Kortum, Jennifer Carns, Tinaye Mutetwa, Richard A. Schwarz , et al. · 2022

INTRODUCTION: In the United States, the effectiveness of anal cancer screening programs has been limited by a lack of trained professionals proficient in high-resolution anoscopy (HRA) and a high patient lost-to-follow-up rate between diag…

A Community-Based Management of COVID-19 in a Mobile Container Unit Open

Е В Петрова, Timothy Farinholt, Tejas P. Joshi, Hannah Moreno, Mayar Al Mohajer , et al. · 2021

Vaccine uptake is a multifactor measure of successful immunization outcomes that includes access to healthcare and vaccine hesitancy for both healthcare workers and communities. The present coronavirus disease (COVID-19) pandemic has highl…

The 9th Symposium on Global Cancer Research: Looking Back and Charting a Path Forward in Global Cancer Control Open

Kalina Duncan, Carl E. Allen, Sharmila Anandasabapathy, Ellen Baker, María T. Bourlon , et al. · 2021

The NCI Center for Global Health convened the 9th Annual Symposium on Global Cancer Research as a virtual 2-day meeting alongside the Consortium of Universities for Global Health Annual Conference, March 10–11, 2021. The virtual format all…

Pregnancy and the Working Gastroenterologist: Perceptions, Realities, and Systemic Challenges Open

Yakira David, Rebekah E. Dixon, Gaurav Kakked, Loren Rabinowitz, Lauren Tal Grinspan , et al. · 2021

Beyond Seattle: WATS and Advanced Imaging in Barrett’s Esophagus Open

Sharmila Anandasabapathy, Nabil Mansour · 2021

Barrett’s esophagus is the sole known precursor for esophageal adenocarcinoma. Endoscopic surveillance for Barrett’s esophagus is recommended to help identify and manage dysplasia, with the ultimate goal being prevention or early detection…

Lifestyle Risk Factors, Quality of Life, and Intervention Preferences of Barrett’s Esophagus Patients: A Prospective Cohort Study Open

Xiaotao Zhang, Sharmila Anandasabapathy, Julian A. Abrams, Mohamed O. Othman, Hoda Badr · 2021

Background and Aims Lifestyle counseling to achieve a healthy weight, quit smoking, and reduce alcohol is a cornerstone in the management of Barrett’s Esophagus (BE). However, little is known about whether patients make these recommended l…

Advances in optical gastrointestinal endoscopy: a technical review Open

Yubo Tang, Sharmila Anandasabapathy, Rebecca Richards‐Kortum · 2020

Optical endoscopy is the primary diagnostic and therapeutic tool for management of gastrointestinal (GI) malignancies. Most GI neoplasms arise from precancerous lesions; thus, technical innovations to improve detection and diagnosis of pre…

Automated software-assisted diagnosis of esophageal squamous cell neoplasia using high-resolution microendoscopy Open

Mimi C. Tan, Sheena Bhushan, Timothy Quang, Richard A. Schwarz, Kalpesh Patel , et al. · 2020

888 GENDER SPECIFIC FACTORS INFLUENCING GASTROENTEROLOGISTS TO PURSUE CAREERS IN ADVANCED ENDOSCOPY: PERCEPTIONS VS REALITY Open

Yakira David, Rebekah E. Dixon, Michelle K. Kim, Gaurav Kakked, Sharmila Anandasabapathy , et al. · 2020

Progress and Challenges of Global High-Resolution Endoscopy Open

Sheena Bhushan, Kortum Rebecca R Richards, Sharmila Anandasabapathy · 2020

In recent years, gastrointestinal endoscopy has seen an influx of high-resolution endoscopic technologies that are capable of providing optical biopsies of the epithelial surface in real time. Upcoming high-resolution endoscopy techniques …

Guidelines for Increasing Female Authorship of GI Society Guidelines Open

Sujita Kumar Kar, Sharmila Anandasabapathy · 2020

Simple differential digital confocal aperture to improve axial response of line-scanning confocal microendoscopes Open

Yubo Tang, Alex Kortum, Imran S. Vohra, Jennifer Carns, Sharmila Anandasabapathy , et al. · 2019

Line-scanning confocal microendoscopy offers video-rate cellular imaging of scattering tissue with relatively simple hardware, but its axial response is inferior to that of point-scanning systems. Based on Fourier optics theory, we designe…

Photoacoustic Imaging in Gastroenterology: Advances and Needs Open

Sheena Bhushan, Sharmila Anandasabapathy, E. V. Petrova · 2019

Gastroenterologists routinely use optical imaging and ultrasound for the minimally invasive diagnosis and treatment of chronic inflammatory diseases and cancerous tumors in gastrointestinal tract and related organs. Recent advances in gast…

Colon cancer in Africa: Primetime for screening? Open

Folasade P. May, Sharmila Anandasabapathy · 2019

Sa1027 – Beyond Availability: Evaluating Acceptability of High Resolution Microendoscopy Among Patients and Providers for Detection of Esophageal Squamous Cell Neoplasia Open

Hongan Chen, Catherine J. Wu, Sheena Bhushan, Tiannan Zhan, Chang Liu , et al. · 2019

Remote Laboratory Management: Respiratory Virus Diagnostics Open

Е В Петрова, Vasanthi Avadhanula, Sarah Michel, Karen E. Gincoo, Pedro A. Piedra , et al. · 2019

An uptick in recent pandemics (Ebola, Zika, MERS, influenza, etc.) underlines the need for a more 'nimble,' coordinated response that addresses a multitude of issues ranging from transportation, access, facilities, equipment, and communica…

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