Sheema Khan
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View article: Targeting Tumor immune microenvironment in GI Cancers 4277
Targeting Tumor immune microenvironment in GI Cancers 4277 Open
Description KRAS mutation on codon-12 is present in 70–95% of Pancreatic Ductal Adenocarcinoma (PDAC) cases and it drives PDAC growth and progression. Galectin-1 (Gal-1) is present in both PDAC and stromal cells, being involved in tumor mi…
View article: Correction: Current paradigm and futuristic vision on new-onset diabetes and pancreatic cancer research
Correction: Current paradigm and futuristic vision on new-onset diabetes and pancreatic cancer research Open
[This corrects the article DOI: 10.3389/fphar.2025.1543112.].
View article: Current paradigm and futuristic vision on new-onset diabetes and pancreatic cancer research
Current paradigm and futuristic vision on new-onset diabetes and pancreatic cancer research Open
New-onset diabetes (NOD) has emerged as a potential early indicator of pancreatic cancer (PC), necessitating a refined clinical approach for risk assessment and early detection. This study discusses critical gaps in understanding the NOD-P…
View article: Curcumin attenuates smoking and drinking activated NF-κB/IL-6 inflammatory signaling axis in cervical cancer
Curcumin attenuates smoking and drinking activated NF-κB/IL-6 inflammatory signaling axis in cervical cancer Open
These data suggest a molecular link between smoking, drinking, and HPV infectivity in cervical carcinogenesis. In addition, attenuation of these effects by treatment with Cur/PLGA-Cur treatment, implies the role of curcumin in cervical can…
View article: Anti-inflammatory Effect of Methanolic Extract of Mangifera Indica Leaves on Inflammed Rats in Comparison to Indomethacin
Anti-inflammatory Effect of Methanolic Extract of Mangifera Indica Leaves on Inflammed Rats in Comparison to Indomethacin Open
In the context of inflammation and immunity, there are fragmented and observational studies relating the pharmacological effects of Mangifera indica leaves and its main active componentmangiferin. Hence, this study aims to evaluate the ant…
View article: FREQUENCY OF OBESITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
FREQUENCY OF OBESITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Open
OBJECTIVE: To determine the frequency of Obesity in patients with Type 2 Diabetes Mellitus in patients visiting the Outpatient department of Khyber Teaching Hospital, Peshawar MATERIALS AND METHODS. This descriptive cross-sectional study w…
View article: Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors
Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors Open
View article: Exosome-Based Smart Drug Delivery for Cancer Treatment
Exosome-Based Smart Drug Delivery for Cancer Treatment Open
Advances in nanoscale materials have become indispensable for targeted drug delivery, early detection, and personalized approaches for cancer treatment. Among various nanoscale materials investigated, exosomes hold significant promise in d…
View article: Ppidb: A Database for Protein-Protein Interactions
Ppidb: A Database for Protein-Protein Interactions Open
View article: Metagenomic analysis unveils the microbial landscape of pancreatic tumors
Metagenomic analysis unveils the microbial landscape of pancreatic tumors Open
The composition of resident microbes in the human body is linked to various diseases and their treatment outcomes. Although studies have identified pancreatic ductal adenocarcinoma (PDAC)-associated bacterial communities in the oral and gu…
View article: Urinary Tract and Gastrointestinal Infections during Pregnancy: Prevalence, Risk Factors, and Clinical Implications in a Pakistani Cohort
Urinary Tract and Gastrointestinal Infections during Pregnancy: Prevalence, Risk Factors, and Clinical Implications in a Pakistani Cohort Open
Background: Urinary tract infections (UTIs) and gastrointestinal (GI) infections are frequent complications of pregnancy and can adversely affect maternal and fetal health. In Pakistan, limited data address their combined prevalence, risk …
View article: An In-depth Examination of Validity Assessment: Exploring Diverse Methodologies and Dimensions of Validity in Social Research Studies
An In-depth Examination of Validity Assessment: Exploring Diverse Methodologies and Dimensions of Validity in Social Research Studies Open
Validity refers to the extent to which a test accurately measures what it claims to measure. Validity is a matter of degree. The study is done to know the various methods of validity. Validity is a fundamental aspect of research quality, w…
View article: Synthesis and Antitumor Activity of Brominated-Ormeloxifene (Br-ORM) against Cervical Cancer
Synthesis and Antitumor Activity of Brominated-Ormeloxifene (Br-ORM) against Cervical Cancer Open
Aberrant regulation of β-catenin signaling is strongly linked with cancer proliferation, invasion, migration, and metastasis, thus, small molecules that can inhibit this pathway might have great clinical significance. Our molecular modelin…
View article: MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway
MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway Open
Anchorage-independent survival after intravasation of cancer cells from the primary tumor site represents a critical step in metastasis. Here, we reveal new insights into how MUC13-mediated anoikis resistance, coupled with survival of colo…
View article: Supplementary Figure 2 from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment
Supplementary Figure 2 from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment Open
PDF file - 153K, Figure S2. Serum proteins adsorption of MNP-CUR formulation.
View article: Supplementary Figure 1 from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment
Supplementary Figure 1 from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment Open
PDF file - 126K, MNP-CUR nanoparticles efficiently internalize in cancer cells.
View article: Supplementary Figure 1 from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment
Supplementary Figure 1 from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment Open
PDF file - 126K, MNP-CUR nanoparticles efficiently internalize in cancer cells.
View article: Supplementary Figure 2 from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment
Supplementary Figure 2 from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment Open
PDF file - 153K, Figure S2. Serum proteins adsorption of MNP-CUR formulation.
View article: Data from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment
Data from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment Open
Curcumin (CUR), a naturally occurring polyphenol derived from the root of Curcuma longa, has showed potent anticancer and cancer prevention activity in a variety of cancers. However, the clinical translation of CUR has been signific…
View article: Data from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment
Data from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment Open
Curcumin (CUR), a naturally occurring polyphenol derived from the root of Curcuma longa, has showed potent anticancer and cancer prevention activity in a variety of cancers. However, the clinical translation of CUR has been signific…
View article: Supplementary Figure S2 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Supplementary Figure S2 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
Supplementary Figure S2. Effect of GDC-0449 and ORM on proliferation, clonogenicity and invasion of PDAC cells.
View article: Supplementary Figure S2 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Supplementary Figure S2 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
Supplementary Figure S2. Effect of GDC-0449 and ORM on proliferation, clonogenicity and invasion of PDAC cells.
View article: Supplementary Figure Legends from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Supplementary Figure Legends from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
Legends for Supplementary Figures S1-S4.
View article: Supplementary Figure S1 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Supplementary Figure S1 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
Supplementary Figure S1. ORM inhibits proliferation and invasion of PDAC cells.
View article: Supplementary Figure S4 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Supplementary Figure S4 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
Supplementary Figure S4. Schematic representation of the treatment regime of xenograft mice.
View article: Supplementary Figure S3 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Supplementary Figure S3 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
Supplementary Figure S3. ORM targets Sonic hedgehog signaling and inhibits NFĸB and Gli-1 transcriptional activity in PDAC cells.
View article: Supplementary Figure S1 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Supplementary Figure S1 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
Supplementary Figure S1. ORM inhibits proliferation and invasion of PDAC cells.
View article: Supplementary Figure S4 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Supplementary Figure S4 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
Supplementary Figure S4. Schematic representation of the treatment regime of xenograft mice.
View article: Supplementary Figure S3 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Supplementary Figure S3 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
Supplementary Figure S3. ORM targets Sonic hedgehog signaling and inhibits NFĸB and Gli-1 transcriptional activity in PDAC cells.
View article: Data from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Data from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer Open
The management of pancreatic ductal adenocarcinoma (PDAC) is extremely poor due to lack of an efficient therapy and development of chemoresistance to the current standard therapy, gemcitabine. Recent studies implicate the intimate reciproc…